Doublecortin expression levels in adult brain reflect neurogenesis.
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...DCX has been shown to serve as a marker for neuronal precursors, and the number of DCX+ cells is positively correlated with the level of adult neurogenesis (Couillard-Despres et al., 2005)....
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...DCX has been shown to serve as a marker for neuronal precursors, and the number of DCX cells is positively correlated with the level of adult neurogenesis (Couillard-Despres et al., 2005)....
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...neurogenesis appears to be restricted to the regions where it was first described: the dentate gyrus and the subventricular zone of the lateral ventricle ⁄ olfactory bulb axis (Altman & Das, 1965; Kaplan & Hinds, 1977; Bayer, 1982; Eriksson et al., 1998; Sanai et al., 2004)....
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...…humans, active neurogenesis appears to be restricted to the regions where it was first described: the dentate gyrus and the subventricular zone of the lateral ventricle ⁄ olfactory bulb axis (Altman & Das, 1965; Kaplan & Hinds, 1977; Bayer, 1982; Eriksson et al., 1998; Sanai et al., 2004)....
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...Until now, with the exception of the proof of the existence of neurogenesis in the adult human dentate gyrus (Eriksson et al., 1998), studies of adult neurogenesis in humans using...
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...Until now, with the exception of the proof of the existence of neurogenesis in the adult human dentate gyrus (Eriksson et al., 1998), studies of adult neurogenesis in humans using BrdU have been limited because of ethical considerations regarding the need of in vivo prelabelling....
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...Here, we further correlated DCX expression with neurogenesis using two paradigms reported to increase the rate of neurogenesis: (i) enhanced voluntary physical activity; and (ii), experimentally induced epileptic lesions (Parent et al., 1997; van Praag et al., 1999b; Brown et al., 2003a)....
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...Moreover, 4 weeks after labelling, voluntary physical activity was shown to increase the relative survival of the newly generated cells as well as the frequency of neuronal differentiation (van Praag et al., 1999b)....
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...The origin of the discrepancy with an earlier study (van Praag et al., 1999a) reporting a significant difference between controls and runners could arise from the different BrdU administration schedule or from a difference in the NeuN detection resulting from the use of distinct anti-NeuN…...
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...Based on previous reports (van Praag et al., 1999b; Brown et al., 2003a, b), two analysis time-points were selected: 14 days and 28 days after the first BrdU administration....
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...…dentate gyrus Enhanced physical activity in C57BL ⁄ 6 J mice, subsequent to the introduction of a running wheel in the cage for a period of 12 days, doubled the cellular proliferation in the dentate gyrus of these mice as compared with mice housed in standard conditions (van Praag et al., 1999b)....
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3,476 citations
"Doublecortin expression levels in a..." refers background in this paper
...…humans, active neurogenesis appears to be restricted to the regions where it was first described: the dentate gyrus and the subventricular zone of the lateral ventricle ⁄ olfactory bulb axis (Altman & Das, 1965; Kaplan & Hinds, 1977; Bayer, 1982; Eriksson et al., 1998; Sanai et al., 2004)....
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...In the subgranular lining of the hippocampal dentate gyrus, cells also divide and continuously generate a pool of neuronal precursors that functionally integrate into the overlaying hippocampal granule cell layer (Altman & Das, 1965; Kaplan & Hinds, 1977; Kuhn et al., 1996; van Praag et al., 2002)....
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"Doublecortin expression levels in a..." refers background in this paper
...Nestin is broadly recognized as a marker for pluripotent neural stem cells (Lendahl et al., 1990)....
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