Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies
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Cites background from "Doxorubicin-induced cardiomyopathy:..."
...Doxorubicin inhibits the collagen transcription and translation in tumour cells (Goetzenich et al., 2009; Octavia et al., 2012; Spallarossa et al., 2006; Tokarska-Schlattner et al., 2010)....
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...Doxorubicin also alters the ATP production (Neri et al., 1991; Pelikan et al., 1986; Sayed-ahmed et al., 2000) and also increases the oxidative stress in mitochondria by enhancing the production of reactive oxygen species (Octavia et al., 2012)....
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...There is an increase in the AGE metabolites (Moriyama et al., 2010), and activation of the reactive oxygen species (Shi et al., 2011) and also it causes the cardiomyopathy (Carvalho et al., 2014; Octavia et al., 2012)....
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..., 2000) and also increases the oxidative stress in mitochondria by enhancing the production of reactive oxygen species (Octavia et al., 2012)....
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..., 2011) and also it causes the cardiomyopathy (Carvalho et al., 2014; Octavia et al., 2012)....
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"Doxorubicin-induced cardiomyopathy:..." refers background in this paper
...In physiological conditions, there would not be enough free iron to couple with doxorubicin to the extent necessary to cause cardiomyopathy [23]....
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...However, the studies showing doxorubicin-induced myocardial dysfunction were often performed with supraclinical concentrations of doxorubicin [23,24]....
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Additional excerpts
...reticulum, namely calpain dysregulation [75]....
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