Driven Polymer Translocation Through a Narrow Pore
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"Driven Polymer Translocation Throug..." refers background in this paper
...There exists a considerable literature on the confinement of polymers in channels of diameter significantly larger than the polymers’ persistence length (de Gennes, 1979); well-developed scaling techniques can be used in the theoretical treatment of this regime....
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...ar X iv :p hy si cs /9 90 20 41 v1 [ ph ys ic s. bi oph ] 1 7 Fe b 19 99 Driven Polymer Translocation Through a Narrow Pore David K. Lubensky and David R. Nelson Department of Physics, Harvard University, Cambridge MA 02138 (February 2, 2008) Motivated by experiments in which a polynucleotide is driven through a proteinaceous pore by an electric field, we study the diffusive motion of a polymer threaded through a narrow channel with which it may have strong interactions....
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...…ic s. bi oph ] 1 7 Fe b 19 99 Driven Polymer Translocation Through a Narrow Pore David K. Lubensky and David R. Nelson Department of Physics, Harvard University, Cambridge MA 02138 (February 2, 2008) Motivated by experiments in which a polynucleotide is driven through a proteinaceous pore by an…...
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...Modern polymer physics has achieved great success with models in which the polymer is regarded as a flexible, uniform “string” whose conformational entropy dominates the system’s behavior (de Gennes, 1979; Doi and Edwards, 1986)....
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...Our arguments assume that the parts of the polynucleotide outside the pore may be described by the theories usually applied to long, flexible polymers (de Gennes, 1979; Doi and Edwards, 1986); we thus ignore, for example, hydrogen-bonding and other specific interactions (Cantor and Schimmel, 1980)....
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10,225 citations
"Driven Polymer Translocation Throug..." refers background or methods in this paper
...Modern polymer physics has achieved great success with models in which the polymer is regarded as a flexible, uniform “string” whose conformational entropy dominates the system’s behavior (de Gennes, 1979; Doi and Edwards, 1986)....
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...Our arguments assume that the parts of the polynucleotide outside the pore may be described by the theories usually applied to long, flexible polymers (de Gennes, 1979; Doi and Edwards, 1986); we thus ignore, for example, hydrogen-bonding and other specific interactions (Cantor and Schimmel, 1980)....
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...However, even with the longest available chains, ν is never observed experimentally to be larger than 0.55 (Doi and Edwards, 1986), so we use this value for specific numerical calculations....
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6,887 citations
"Driven Polymer Translocation Throug..." refers background or methods in this paper
...This calculation can be formulated as one of a wellstudied class of problems known as first-passage problems (Risken, 1984; van Kampen, 1992)....
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...Approximate formulas based on the Kramers escape rate (van Kampen, 1992) should then apply....
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3,383 citations
"Driven Polymer Translocation Throug..." refers background in this paper
...Such a random force, however small, would in principle result in anomalous diffusion on sufficiently long length scales (Bouchaud and Georges, 1990; Fisher et al., 1998)....
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...It is known that one-dimensional diffusion becomes anomalous when [U(x) − U(0)]2 → ∞ as x→ ∞, where the overbar indicates an average with respect to the random distribution of bases (Bouchaud and Georges, 1990; le Doussal and Vinokur, 1995; Scheidl, 1995)....
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...Once all four possible situations have been explored experimentally, however, it should be possible, for example, to estimate the value of α by comparing data for the appropriate pairs of situations....
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...Since it is known that diffusion in random media can be qualitatively different from diffusion in ordered systems (Bouchaud and Georges, 1990), it is worth asking whether we expect any important changes when the homopolymer is replaced by a random heteropolymer....
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3,251 citations
"Driven Polymer Translocation Throug..." refers background in this paper
...For example, Kasianowicz, Brandin, Branton, and Deamer (hereafter KBBD) have recently detected single strands of RNA (polyuridylic acid) passing through a 1.5 nm pore formed by a membrane-bound protein (Kasianowicz et al., 1996)....
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