Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells
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TLDR
Initial biochemical and functional characterization of the dRET protein in cell culture systems indicate significant conservation between the biological effects elicited by the human and Drosophila RET kinases, and suggest functions for dRET in neuronal differentiation in the fly.About:
This article is published in FEBS Letters.The article was published on 2005-07-04 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & Tyrosine phosphorylation.read more
Citations
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Journal ArticleDOI
VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects
Christopher R. Heier,Jesse M. Damsker,Qing Yu,Blythe C. Dillingham,Tony Huynh,Jack H. Van der Meulen,Arpana Sali,Brittany K. Miller,Aditi Phadke,Luana Scheffer,James L Quinn,Kathleen Tatem,Sarah Jordan,Sherry Dadgar,Olga Rodriguez,Chris Albanese,Michael E. Calhoun,Heather Gordish-Dressman,Jyoti K. Jaiswal,Edward M. Connor,John M. McCall,Eric P. Hoffman,Erica K.M. Reeves,Kanneboyina Nagaraju +23 more
TL;DR: Successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects is demonstrated, indicating VBP15 merits clinical investigation for DMD and would benefit other chronic inflammatory diseases.
Journal ArticleDOI
Structure and Physiology of the RET Receptor Tyrosine Kinase
TL;DR: The discovery of ret opened a field of study that has had a profound impact in cancer research, developmental biology, and neuroscience, and that continues to yield surprises and important insights to this day.
Coordinated Activation of Autophosphorylation Sites in the RET
TL;DR: The catalytic and signaling activities of RET, a tyrosine kinase receptor for glial cell line-derived neurotrophic factor (GDNF), are controlled by the autophosphorylation of several tyrosines in the RET cytoplasmic domain this article.
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Evolution of the GDNF family ligands and receptors.
TL;DR: The presence of RET- and GFR-like genes in insects suggests that a ProtoGFR and a ProtoRET arose early in the evolution of bilaterian animals, but when the ProtoGFL diverged from existing transforming growth factor (TGFβ)-like proteins remains unclear.
Journal ArticleDOI
Receptor Tyrosine Kinases in Drosophila Development
Richelle Sopko,Norbert Perrimon +1 more
TL;DR: A comprehensive review of what is known regarding each receptor tyrosine kinase during Drosophila development highlights the importance of knowing the structure and function of these enzymes in the context of cell survival and proliferation.
References
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Book ChapterDOI
Comparative Genomics in Eukaryotes
Alan Filipski,Sudhir Kumar +1 more
TL;DR: This chapter outlines the development and current status of comparative eukaryotic genomics, from the earliest studies of basic chromosome structure to the sequencing of entire genomes, and a review is provided for the structure, organization, and composition of the primary eukARYotic genomes that have been sequenced thus far.
Journal ArticleDOI
The GDNF/RET signaling pathway and human diseases.
TL;DR: The signaling pathways activated by GDNF or mutant RET are being extensively investigated to understand the molecular mechanisms of disease development and the physiological roles of the GDNF family ligands.
Journal ArticleDOI
ret transforming gene encodes a fusion protein homologous to tyrosine kinases.
TL;DR: The ret transforming gene was activated by recombination between two unlinked segments of human DNA, most likely during transfection of NIH 3T3 cells, and encoded a fusion protein with a carboxy-terminal domain which is 40 to 50% homologous to members of the tyrosine kinase gene family.
Journal ArticleDOI
Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation.
Barbara L. Hempstead,Stuart J. Rabin,Leni Kaplan,Susan W. Reid,Luis F. Parada,David R. Kaplant +5 more
TL;DR: The data indicate that overexpression of gp140trk in PC12 cells markedly accelerates NGF-induced differentiation pathways, possibly through the elevation of gp 140trk tyrosine kinase activity.
Journal ArticleDOI
The RET proto-oncogene in human cancers.
TL;DR: The identification of RET mutations in most MEN 2 families (95%) has translated into improved care for MEN 2 patients, and further investigation of the signaling pathways contributing to tumorigenesis in relevant tissues will eventually help to develop novel strategies to prevent or to treat human papillary thyroid carcinomas, MEN 2 disease, as well as the sporadic cancers relevant to MEN2 disease.