Drosophila RET contains an active tyrosine kinase and elicits neurotrophic activities in mammalian cells
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TLDR
Initial biochemical and functional characterization of the dRET protein in cell culture systems indicate significant conservation between the biological effects elicited by the human and Drosophila RET kinases, and suggest functions for dRET in neuronal differentiation in the fly.About:
This article is published in FEBS Letters.The article was published on 2005-07-04 and is currently open access. It has received 32 citations till now. The article focuses on the topics: Glial cell line-derived neurotrophic factor & Tyrosine phosphorylation.read more
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VBP15, a novel anti-inflammatory and membrane-stabilizer, improves muscular dystrophy without side effects
Christopher R. Heier,Jesse M. Damsker,Qing Yu,Blythe C. Dillingham,Tony Huynh,Jack H. Van der Meulen,Arpana Sali,Brittany K. Miller,Aditi Phadke,Luana Scheffer,James L Quinn,Kathleen Tatem,Sarah Jordan,Sherry Dadgar,Olga Rodriguez,Chris Albanese,Michael E. Calhoun,Heather Gordish-Dressman,Jyoti K. Jaiswal,Edward M. Connor,John M. McCall,Eric P. Hoffman,Erica K.M. Reeves,Kanneboyina Nagaraju +23 more
TL;DR: Successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects is demonstrated, indicating VBP15 merits clinical investigation for DMD and would benefit other chronic inflammatory diseases.
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Structure and Physiology of the RET Receptor Tyrosine Kinase
TL;DR: The discovery of ret opened a field of study that has had a profound impact in cancer research, developmental biology, and neuroscience, and that continues to yield surprises and important insights to this day.
Coordinated Activation of Autophosphorylation Sites in the RET
TL;DR: The catalytic and signaling activities of RET, a tyrosine kinase receptor for glial cell line-derived neurotrophic factor (GDNF), are controlled by the autophosphorylation of several tyrosines in the RET cytoplasmic domain this article.
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Evolution of the GDNF family ligands and receptors.
TL;DR: The presence of RET- and GFR-like genes in insects suggests that a ProtoGFR and a ProtoRET arose early in the evolution of bilaterian animals, but when the ProtoGFL diverged from existing transforming growth factor (TGFβ)-like proteins remains unclear.
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Receptor Tyrosine Kinases in Drosophila Development
Richelle Sopko,Norbert Perrimon +1 more
TL;DR: A comprehensive review of what is known regarding each receptor tyrosine kinase during Drosophila development highlights the importance of knowing the structure and function of these enzymes in the context of cell survival and proliferation.
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The zebrafish homologue of the ret receptor and its pattern of expression during embryogenesis
TL;DR: The conservation of ret1 expression in cell types which remain unaffected by the mammalian c-ret mutations, such as motor and sensory neurons, suggests a function of this receptor in these cell lineages.
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Intrinsic susceptibility to misfolding of a hot-spot for Hirschsprung disease mutations in the ectodomain of RET.
Svend Kjaer,Carlos F. Ibáñez +1 more
TL;DR: The intrinsic susceptibility to misfolding of mammalian RETECD may be the result of a trade-off that helps to avoid an increased incidence of tumors, at the expense of a greater vulnerability to Hirschsprung disease.
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Identification of a Surface for Binding to the GDNF-GFRα1 Complex in the First Cadherin-like Domain of RET
Svend Kjaer,Carlos F. Ibáñez +1 more
TL;DR: The RET receptor tyrosine kinase is activated by binding to a ligand complex formed by a member of the glial cell line-derived neurotrophic factor (GDNF) family of neurotrophic factors bound to its cognate GDNF-family receptor-α (GFRα) glycosylphosphatidylinositol-linked co-receptor.
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Expression pattern of Drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons.
Mounou Hahn,J. Michael Bishop +1 more
TL;DR: Drosophila ret encodes a protein of 1,235 amino acids that has all of the domains identified in the vertebrate ret, including a cadherin motif, which suggests a previously unrecognized phylogenetic relationship between the ret-expressing cells in vertebrates and the precursor reserves of metamorphosing insects.
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A Drosophila homolog of human proto-oncogene ret transiently expressed in embryonic neuronal precursor cells including neuroblasts and CNS cells
TL;DR: The results suggest that Dret can be considered as a functional homolog of mammalian ret and should play important roles in neurogenesis.