Drugs, toxins and dietary amino acids affecting vitamin B12 or folic acid absorption or utilization.
TL;DR: Comparison of short-term cultures of human bone marrow with similar cultures of pathogenic microorganisms or neoplastic cells can measure the relative effects of new or suspected FAA on folate-dependent steps in DNA synthesis in vitro and may make it possible to predict use in vivo.
About: This article is published in The American Journal of Medicine.The article was published on 1970-05-01. It has received 90 citations till now. The article focuses on the topics: Megaloblastic anemia & Vitamin.
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01 Sep 1973
TL;DR: The CRC Critical Reviews in Clinical Laboratory Sciences: Vol. 4, No. 3, No 3, pp 215-340 as discussed by the authors was the first publication of a comprehensive review of laboratory tests for the assessment of nutritional status.
Abstract: (1973). Laboratory Tests for the Assessment of Nutritional Status. CRC Critical Reviews in Clinical Laboratory Sciences: Vol. 4, No. 3, pp. 215-340.
458 citations
TL;DR: Depression of cellular or humoral immunity, or both, was found in a significant number of phenytoin-treated and lymphoma subjects.
166 citations
01 Oct 1988
TL;DR: The hematopoietic system is composed of a remarkable variety of cells, including those circulating in the blood and their ancestors in marrow and progeny in the tissues as discussed by the authors.
Abstract: The hematopoietic system is composed of a remarkable variety of cells. Included are those circulating in the blood and their ancestors in marrow and progeny in the tissues. Also included are cells whose function is to remove both senescent cells from the bloodstream and any foreign material, especially microorganisms that may gain entrance to the body. After birth, the major location for hematopoiesis is the bone marrow, and in the newborn animal all medullary cavities of the skeleton are given over to this purpose. As the demands of body growth subside, hematopoiesis normally retreats to the metaphyses of long bones and to the flat bones of the pelvis, ribs, calvarium and vertebrae. From here, it may re-expand if need be, both into the bony cavities and even into extraskeletal sites such as the liver, spleen and lymph nodes. Hematopoietic stem cells are extravascular colonists in bone marrow and here they proliferate, differentiate and mature, being finally released as appropriately developed progeny into the circulation. These end cells have acquired sufficient membrane plasticity and movement to penetrate sinusoidal endothelium and leave the marrow. The hematopoietic cell system consists of a hierarchy in which the progenitor stem cells are capable of unlimited self-renewal and multilineal differentiation, giving rise to all blood cell types via committed precursor cells (Fig. 3.1). Committed precursor cells have a limited capacity for self-renewal and differentiation. The control of stem cell differentiation is little understood but is apparently initiated by the interaction of helper and suppressor lymphocytes and modulated by hormones specific for each cell line (Table 3.1).
151 citations
119 citations
TL;DR: The mechanisms of drug-induced gingival hyperplasia (overgrowth) are discussed in relationship to the drugs' pharmacodynamics and pharmacokinetics.
Abstract: The periodontium and periodontal disease activity can be affected by systemic drug therapy. Many drugs can have an adverse effect on the periodontium, i.e., gingival hyperplasia. Alternatively, some drugs can modify the inflammatory and immunological responses of the periodontal tissues to bacterial plaque. The aim of this review is to evaluate the effects of drug therapy on the periodontium and periodontal disease activity, and where possible, to relate such changes to the pharmacodynamics of the drugs considered. Drugs which have been reported to affect the periodontium can be categorised as follows: anti-epileptics, immunosuppressants, corticosteroids, non-steroidal anti-inflammatory drugs and hormones. Those drugs whose pharmacodynamics are clearly established and which affect the rate of periodontal disease activity, may provide information on the mechanisms of periodontal destruction. Finally, the mechanisms of drug-induced gingival hyperplasia (overgrowth) are discussed in relationship to the drugs' pharmacodynamics and pharmacokinetics.
118 citations
References
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17,697 citations
Book•
01 Jan 2000
TL;DR: In this article, 42 authors share the herculean task of reviewing the flood of recent literature on pharmacology and rational use of drugs, under single or dual authorship they contribute the 76 chapters in the 18 sections.
Abstract: on pharmacology and the rational use of drugs, 42 authors share the herculean task of reviewing the flood of recent literature. Under single or dual authorship they contribute the 76 chapters in the 18 sections. The "liberal use of extract (fine) type as a space-saving device" allows nearly twice as much material under one cover. Although portions printed in smaller type "are of somewhat lesser importance," in most cases it will be necessary and profitable to read these. For example, extract type is used to narrate the historical background and to discuss complex structure-activity relationships, significant laboratory and clinical studies, the types of preparations, dosages and routes of administration, side effects and adverse reactions, and the therapeutic uses. Each chapter offers a complete and up-to-date review. Usually, enough information is given so that
9,817 citations
TL;DR: The occurrence of what the author interpreted as an "acceleration phenomenon" in the leukemic process as seen in the marrow and viscera of children with acute leukemia treated by the injection of folic acid conjugates1 and pteroyltriglutamic acid (teropterin) — and an experience gained from studies on folic .
Abstract: IT IS the purpose of this paper to record the results of clinical and hematologic studies on 5 children with acute leukemia treated by the intramuscular injection of a synthetic compound, 4-aminopteroylglutamic acid (aminopterin). This substance is an antagonist to folic acid regarding the growth of Streptococcus faecalis R. The occurrence of what he interpreted as an "acceleration phenomenon" in the leukemic process as seen in the marrow and viscera of children with acute leukemia treated by the injection of folic acid conjugates1 — pteroyltriglutamic acid (teropterin) and pteroyldiglutamic acid (diopterin) — and an experience gained from studies on folic . . .
1,543 citations
Book•
01 Jan 1969
867 citations
"Drugs, toxins and dietary amino aci..." refers background in this paper
...The folic acid analogues [1,2] include a group of compounds which have a chemical structure sufficiently similar to that of folic acid to act as folic acid antagonists (FAA)....
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