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Proceedings ArticleDOI

Dual-Comb Biosensing for Rapid Detection of SARS-CoV-2

TL;DR: This work demonstrated rapid detection of SARS-CoV-2 nucleocapsid protein antigen by dual-comb biosensing with surface modification of its corresponding antibody with a sensitivity close to that of RT-PCR.
Abstract: We demonstrated rapid detection of SARS-CoV-2 nucleocapsid protein antigen by dual-comb biosensing with surface modification of its corresponding antibody. A sensitivity close to that of RT-PCR was achieved, thanks to the use of active–dummy temperature compensation.
References
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Journal ArticleDOI
14 Mar 2002-Nature
TL;DR: The ability to count optical oscillations of more than 1015 cycles per second facilitates high-precision optical spectroscopy, and has led to the construction of an all-optical atomic clock that is expected eventually to outperform today's state-of-the-art caesium clocks.
Abstract: Extremely narrow optical resonances in cold atoms or single trapped ions can be measured with high resolution. A laser locked to such a narrow optical resonance could serve as a highly stable oscillator for an all-optical atomic clock. However, until recently there was no reliable clockwork mechanism that could count optical frequencies of hundreds of terahertz. Techniques using femtosecond-laser frequency combs, developed within the past few years, have solved this problem. The ability to count optical oscillations of more than 1015 cycles per second facilitates high-precision optical spectroscopy, and has led to the construction of an all-optical atomic clock that is expected eventually to outperform today's state-of-the-art caesium clocks.

2,612 citations

Book ChapterDOI
Thomas Udem1
01 Jan 2005

168 citations

Journal ArticleDOI
TL;DR: In this article, a chromatic adaptation transform for black-body radiators of temperature T is presented, and the generalization of the results to arbitrary well-behaved illuminants is discussed.
Abstract: The almost-illuminant-independent achromatic variable zeta [J. Opt. Soc. Am A 11, 1003 (1994)] is supplemented by two achromatic variables, both almost illuminant-independent. The results are numerically verified and obtained by means of so-called (human) visual system-response functions, defined as those linear combinations of the color-matching functions that constitute the best possible approximations to delta functions. It is argued that they and not the cone sensitivities are basic to understanding the visual system as a color-constant signal detection system. The three variables solve the color-constancy problem and define a chromatic adaptation transform for blackbody radiators of temperature T. The generalization of the results to arbitrary well-behaved illuminants is discussed.

71 citations

Journal ArticleDOI
TL;DR: In this paper, a coherent link between the optical and radio frequencies is proposed to enable high-precision refractive index measurement based on frequency measurement in radio-frequency (RF) region.
Abstract: Optical frequency combs (OFCs) have attracted attention as optical frequency rulers due to their tooth-like discrete spectra together with their inherent mode-locking nature and phase-locking control to a frequency standard. Based on this concept, their applications until now have been demonstrated in the fields of optical frequency metrology. However, if the utility of OFCs can be further expanded beyond their application by exploiting new aspects of OFCs, this will lead to new developments in optical metrology and instrumentation. Here, we report a fiber sensing application of OFCs based on a coherent link between the optical and radio frequencies, enabling high-precision refractive index measurement based on frequency measurement in radio-frequency (RF) region. Our technique encodes a refractive index change of a liquid sample into a repetition frequency of OFC by a combination of an intracavity multi-mode-interference fiber sensor and wavelength dispersion of a cavity fiber. Then, the change in refractive index is read out by measuring the repetition frequency in RF region based on a frequency standard. Use of an OFC as a photonic RF converter will lead to the development of new applications in high-precision fiber sensing with the help of functional fiber sensors and precise RF measurement.

24 citations

Journal ArticleDOI
TL;DR: In this paper, a mechanical sharing, dual-comb fiber laser based on an all-polarization-maintaining cavity configuration and a nonlinear amplifier and a loop mirror mode-locking mechanism is presented.
Abstract: We present a mechanical sharing, dual-comb fiber laser based on an all-polarization-maintaining cavity configuration and a nonlinear amplifying loop mirror mode-locking mechanism. This simple setup yields dual-optical frequency combs with a high level of mutual coherence without active servo control. We realized a high relative stability with a standard deviation of 0.27 Hz and a relative beat note between the dual-frequency combs with a full-width at half-maximum of ∼50Hz. Dual-frequency combs were found to have high relative stability and mutual coherence owing to passive common-mode noise suppression using a mechanical sharing laser cavity. This laser configuration can significantly simplify dual-comb spectroscopy.

15 citations