Dynamics in the plasma membrane: how to combine fluidity and order
Didier Marguet,Didier Marguet,Pierre-François Lenne,Pierre-François Lenne,Hervé Rigneault,Hervé Rigneault,Hai-Tao He,Hai-Tao He +7 more
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TLDR
The basic concepts of Brownian diffusion and lipid domain formation in model membranes are summarized and the development of ideas and tools in this field are tracked, outlining key results obtained on the dynamic processes at work in membrane structure and assembly.Abstract:
Cell membranes are fascinating supramolecular aggregates that not only form a barrier between compartments but also harbor many chemical reactions essential to the existence and functioning of a cell. Here, it is proposed to review the molecular dynamics and mosaic organization of the plasma membrane, which are thought to have important functional implications. We will first summarize the basic concepts of Brownian diffusion and lipid domain formation in model membranes and then track the development of ideas and tools in this field, outlining key results obtained on the dynamic processes at work in membrane structure and assembly. We will focus in particular on findings made using fluorescent labeling and imaging procedures to record these dynamic processes. We will also discuss a few examples showing the impact of lateral diffusion on cell signal transduction, and outline some future methodological challenges which must be met before we can answer some of the questions arising in this field of research.read more
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Selective roles for cholesterol and actin in compartmentalization of different proteins in the Golgi and plasma membrane of polarized cells. VOLUME 283 (2008) PAGES 29545-29553
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Direct imaging of transmembrane dynamics of single nanoparticles with darkfield microscopy: improved orientation tracking at cell sidewall.
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Solid character of membrane ceramides: a surface rheology study of their mixtures with sphingomyelin.
Elisa R. Catapano,Laura R. Arriaga,Laura R. Arriaga,Gabriel Espinosa,Francisco Monroy,Francisco Monroy,Dominique Langevin,Iván López-Montero +7 more
TL;DR: Ceramide increases the solid character of sphingomyelin-based membranes and decreases their fluidity, thus drastically decreasing the lateral mobilities of embedded objects, which may involve important physiological consequences in biological membranes containing ceramides.
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Purine Bases Oxidation and Repair Following Permethrin Insecticide Treatment in Rat Heart Cells
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Functional membrane diffusion of G-protein coupled receptors
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TL;DR: Advances in understanding the functional dynamics of the receptor resulting from diffusion measurements are discussed, and in the context of the plasma membrane organization.
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