Dynamics in the plasma membrane: how to combine fluidity and order
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...in cell signaling, adhesion and trafficking (1-3)....
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150 citations
Cites background from "Dynamics in the plasma membrane: ho..."
...Although the fluid mosaic picture allows for a satisfactory description of the molecular dynamics of the embedded objects (8, 11, 12), lacking of viscoelastic contributions could result in an incomplete understanding of membrane processes....
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...A fundamental question arises in this context: What is the subtle interplay of interactions between the different lipids that endows such a unique mechanical behavior of biological membranes (8)? If lipid domains are present in real membranes, not only energetic contributions arising from line tension and long-range domain interactions must be explicitly considered in the mechanical kernel of the membrane (25, 41) but also kinetic effects related to the multiphase transport (42, 43) could nontrivially shape the functional dynamics in such heterogeneous membranes....
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146 citations
Cites background from "Dynamics in the plasma membrane: ho..."
...property of cell membranes [10] and are of importance in e....
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144 citations
Cites background from "Dynamics in the plasma membrane: ho..."
...…QD–ChTx at synapses Lipid phase segregation may affect the lateral diffusion of molecules belonging to rafts such as GM1 or GPI-anchored proteins, because they are transiently trapped and slowed down in these domains whose existence depends on cholesterol (Edidin, 2003; Marguet et al., 2006)....
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...Lipid domains of different viscosity (lipid rafts) can also reduce the lateral mobility of proteins associated with them (for review, see Marguet et al., 2006)....
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...Cholesterol depletion increases the diffusion of slowly mobile QD–ChTx at synapses Lipid phase segregation may affect the lateral diffusion of molecules belonging to rafts such as GM1 or GPI-anchored proteins, because they are transiently trapped and slowed down in these domains whose existence depends on cholesterol (Edidin, 2003; Marguet et al., 2006)....
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142 citations
References
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"Dynamics in the plasma membrane: ho..." refers background in this paper
...The use of fluorescent quantum dots is emerging as a promising alternative to classical fluorescent tags (GFPs and organic fluorophores) (Michalet et al, 2005)....
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...…quantum yields, large molar extinction coefficients, size-dependent tunable emission and high photostability) make them appeal- &2006 European Molecular Biology Organization The EMBO Journal VOL 25 | NO 15 | 2006 3449 ing candidate tags for use with SDT (Dahan et al, 2003; Michalet et al, 2005)....
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5,875 citations
"Dynamics in the plasma membrane: ho..." refers background in this paper
...However, there is still a need to improve the functionalization of QD surfaces, the flexibility for bioconjugations and single irreversible molecular associations between individually tracked molecules (Medintz et al, 2005)....
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3,041 citations
"Dynamics in the plasma membrane: ho..." refers background in this paper
...Brownian motion is a principle that applies to all biological systems (Berg, 1983): as the result of thermal agitation processes, molecules are constantly on the move, colliding with each other and bouncing back and forth (Figure 1)....
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...…plasma membrane dynamics Brownian motion, diffusion and membrane organization Brownian motion is a principle that applies to all biological systems (Berg, 1983): as the result of thermal agitation processes, molecules are constantly on the move, colliding with each other and bouncing back and…...
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2,933 citations
"Dynamics in the plasma membrane: ho..." refers background in this paper
...As the cDNA encoding the GFP was characterized, a wide variety of monomeric fluorescent proteins have provided attractive potential candidates for monitoring dynamic processes in which different molecular species are simultaneously involved (for a review, see Shaner et al, 2005)....
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