Journal ArticleDOI
Early Azathioprine Therapy Is No More Effective Than Placebo for Newly Diagnosed Crohn's Disease
Julián Panés,Antonio López Sanromán,Fernando Bermejo,Valle García Sánchez,Maria Esteve,Yolanda Torres,Eugeni Domènech,M Piqueras,María Gomez–García,Ana Gutiérrez,Carlos Taxonera,Miquel Sans +11 more
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TLDR
In a study of adults with Crohn's disease, early azathioprine therapy was no more effective than placebo to achieve sustained corticosteroid-free remission but was more effective in preventing moderate to severe relapse in a post hoc analysis.About:
This article is published in Gastroenterology.The article was published on 2013-10-01. It has received 213 citations till now. The article focuses on the topics: Crohn's Disease Activity Index & Azathioprine.read more
Citations
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Journal ArticleDOI
Crohn's disease
TL;DR: An physician-oriented overview of Crohn's disease in adults is provided, ranging from epidemiology and cause to clinical diagnosis, natural history, patient stratification and clinical management, and ending with an overview of emerging therapies and future directions for research.
Journal ArticleDOI
Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease.
Frank M. Ruemmele,Frank M. Ruemmele,Frank M. Ruemmele,Gábor Veres,Kaija-Leena Kolho,Anne Griffiths,Arie Levine,Johanna C. Escher,J. Amil Dias,Arrigo Barabino,Christian Braegger,Jiri Bronsky,Stephan Buderus,Javier Martín-de-Carpi,L. de Ridder,Ulrika L. Fagerberg,Jean-Pierre Hugot,Jaroslaw Kierkus,Sanja Kolaček,Sibylle Koletzko,Paolo Lionetti,Erasmo Miele,V.M. Navas Lopez,Anders Paerregaard,Richard K Russell,Daniela Elena Serban,Ron Shaoul,P. van Rheenen,Gigi Veereman,B Weiss,David Wilson,Axel Dignass,A Eliakim,Harland S. Winter,Dan Turner +34 more
TL;DR: These guidelines are intended to give practical (whenever possible evidence-based) answers to (pediatric) gastroenterologists who take care of children and adolescents with CD, since many different clinical scenario exist requiring treatment strategies not covered by or different from these guidelines.
Journal ArticleDOI
ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment
Joana Torres,Stefanos Bonovas,Glen A. Doherty,Torsten Kucharzik,Javier P. Gisbert,Tim Raine,Michel Adamina,Michel Adamina,Alessandro Armuzzi,Oliver Bachmann,Palle Bager,Livia Biancone,Bernd Bokemeyer,Peter Bossuyt,Johan Burisch,Paul Collins,Alaa El-Hussuna,Pierre Ellul,Cornelia Frei-Lanter,Federica Furfaro,Christian Gingert,Paolo Gionchetti,Fernando Gomollón,Marien González-Lorenzo,Hannah Gordon,Tibor Hlavaty,Pascal Juillerat,Konstantinos H. Katsanos,Uri Kopylov,Eduards Krustins,Theodore Lytras,Christian Maaser,Fernando Magro,John Marshall,Pär Myrelid,Gianluca Pellino,Isadora Rosa,João Sabino,Edoardo Savarino,Antonino Spinelli,Laurents P. S. Stassen,Mathieu Uzzan,Stephan R. Vavricka,Bram Verstockt,Janindra Warusavitarne,Oded Zmora,Gionata Fiorino +46 more
TL;DR: The present article addresses surgical management, including preoperative aspects and drug management before surgery, and provides technical advice for a variety of common clinical situations.
Journal ArticleDOI
Azathioprine or 6-mercaptopurine for induction of remission in Crohn's disease.
TL;DR: There was no statistically significant difference in withdrawals due to adverse events or serious adverse events between antimetabolites and placebo, and azathioprine was significantly inferior to infliximab for induction of steroid-free clinical remission.
Journal ArticleDOI
Azathioprine or 6-mercaptopurine for maintenance of remission in Crohn's disease
TL;DR: An updated meta-analysis of randomized controlled trials of oral azathioprine or 6-mercaptopurine compared to placebo or active therapy involving adult patients with quiescent Crohn's disease showed that AZA was significantly superior to placebo for maintenance of remission over a 6 to 18 month period.
References
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Journal ArticleDOI
Development of a Crohn's Disease Activity Index: National Cooperative Crohn's Disease Study
TL;DR: In this paper, a multiple regression computer program was utilized to derive an equation for prediction of the physician's over-all ratings from a subset of the predictor variables fulfilling a combination of constraints.
Journal ArticleDOI
Infliximab, Azathioprine, or Combination Therapy for Crohn's Disease
Jean-Frederic Colombel,William J. Sandborn,Walter Reinisch,Gerassimos J. Mantzaris,Asher Kornbluth,Daniel Rachmilewitz,Simon Lichtiger,Robert H. Diamond,Delma L. Broussard,Kezhen L. Tang,C. Janneke van der Woude,Paul Rutgeerts +11 more
TL;DR: Patients with moderate-to-severe Crohn's disease who were treated with infliximab plus azathioprine or inflIXimab monotherapy were more likely to have a corticosteroid-free clinical remission than those receiving azATHioprine monotherapy.
Journal ArticleDOI
The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis
Gert Van Assche,Axel Dignass,Julián Panés,Laurent Beaugerie,John A. Karagiannis,Mathieu Allez,Thomas Ochsenkühn,Timothy R. Orchard,Gerhard Rogler,Edouard Louis,Limas Kupčinskas,Gerassimos J. Mantzaris,Simon Travis,Eduard F. Stange +13 more
TL;DR: The aim of the Consensus is to promote a European perspective on the management of Crohn's disease and its dilemmas to avoid duplication of effort in the future.
Journal ArticleDOI
National Cooperative Crohn's Disease Study: results of drug treatment.
Robert W. Summers,Donald M. Switz,John T. Sessions,Jack M. Becktel,William R. Best,Fred Kern,John W. Singleton +6 more
TL;DR: Patients' drug therapy immediately before entry to the study significantly affected subsequent response, and none of the drugs was superior to placebo in prophylaxis against flare-up or recurrence.
Related Papers (5)
Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial
Geert R. D'Haens,Filip Baert,Gert Van Assche,Philip Caenepeel,Philippe Vergauwe,Hans Tuynman,Martine De Vos,Sander J. H. van Deventer,Larry Stitt,Allan Donner,Allan Donner,Severine Vermeire,Frank J. Van de Mierop,Jean-Charles R Coche,Janneke van der Woude,Thomas Ochsenkühn,Ad A. van Bodegraven,Philippe Van Hootegem,Guy Lambrecht,Fazia Mana,Paul Rutgeerts,Brian G. Feagan,Brian G. Feagan,Daniel W. Hommes +23 more