EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis
Paolo Angeli,Mauro Bernardi,Càndid Villanueva,Claire Francoz,Rajeshwar P. Mookerjee,Jonel Trebicka,Aleksander Krag,Wim Laleman,Pere Ginès +8 more
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TLDR
The panel of experts, having emphasised the importance of initiating aetiologic treatment for any degree of hepatic disease at the earliest possible stage, extended its work to all the complications of cirrhosis which had not been covered by the European Association for the Study of the Liver guidelines.About:
This article is published in Journal of Hepatology.The article was published on 2018-08-01 and is currently open access. It has received 1534 citations till now. The article focuses on the topics: Hepatorenal syndrome & Cirrhosis.read more
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Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
TL;DR: An initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI is described.
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Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study
TL;DR: Mortality due to cirrhosis has been increasing in the US since 2009, driven entirely by alcohol related liver disease, and people aged 25-34 have experienced the greatest relative increase in mortality.
Journal Article
Enoxaparin Prevents Portal Vein Thrombosisand Liver Decompensation in Patients With Advanced Cirrhosis.
Calogero Cammà,Salvatore Petta,Cristina Tata,Mariagrazia Del Buono,Filippo Schepis,Monica Luongo,Nicola De Maria,Marco Marietta,Giovanni Fornaciari,Barbara Lei,Dominique Valla,Dominique Valla,Stefano Colopi,Veronica Bernabucci,Ranka Vukotic,Stefano Gitto,Rosina Maria Critelli,Aimilia Karampatou,Elena Turola,Erica Villa,Luisa Simoni,Susanna Schianchi,Beatrice Zambotto,Ramona Zecchini,Cristian Caporali,Anna Ferrari +25 more
TL;DR: In a small randomized controlled trial, a 12-month course of enoxaparin was safe and effective in preventing PVT in patients with cirrhosis and a Child-Pugh score of 7-10 and to improve survival.
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High rates of 30-day mortality in patients with cirrhosis and COVID-19.
Massimo Iavarone,Roberta D'Ambrosio,Alessandro Soria,Michela Triolo,Nicola Pugliese,Paolo Poggio,Giovanni Perricone,Sara Massironi,Angiola Spinetti,Elisabetta Buscarini,Mauro Viganò,Canio Carriero,Stefano Fagiuoli,Alessio Aghemo,Luca S. Belli,Martina Lucà,Marianna Pedaci,Alessandro Rimondi,Maria Grazia Rumi,Pietro Invernizzi,Paolo Bonfanti,Pietro Lampertico +21 more
TL;DR: COVID-19 is associated with liver function deterioration and elevated mortality in cirrhotic patients with confirmed SARS-CoV-2 infection, and Severity of lung and liver (according to CLIF-C, CLif-OF and MELD scores) diseases independently predicted mortality.
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Epidemiology and Effects of Bacterial Infections in Patients With Cirrhosis Worldwide
Salvatore Piano,Virendra Singh,Paolo Caraceni,Rakhi Maiwall,Carlo Alessandria,Javier Romaní Fernández,Elza Cotrim Soares,Dong Joon Kim,Sung Eun Kim,M. Marino,Julio Vorobioff,Rita de Cassia Ribeiro Barea,Manuela Merli,Laure Elkrief,Victor Vargas,Aleksander Krag,Shivaram Prasad Singh,Laurentius A. Lesmana,C. Toledo,Sebastián Marciano,Xavier Verhelst,Florence Wong,Nicolas M. Intagliata,Liane Rabinowich,Luis Colombato,Sang Gyune Kim,Alexander L. Gerbes,François Durand,Juan Pablo Roblero,Kalyan Ram Bhamidimarri,Thomas D. Boyer,M. V. Maevskaya,Eduardo Fassio,Hyoung Su Kim,Jae Seok Hwang,Pere Ginès,Adrián Gadano,Shiv Kumar Sarin,Paolo Angeli,Michele Bartoletti,Carlos Brodersen,Tony Bruns,Robert A. de Man,Annette Dam Fialla,Carmine Gambino,Vikas Gautam,Marcos Girala,Adrià Juanola,Jeong Han Kim,Tae Hun Kim,Pramod Kumar,Barbara Lattanzi,Tae Hee Lee,Cosmas A. Rinaldi Lesmana,Richard Moreau,Preetam Nath,Gustavo Navarro,Ji Won Park,Gisela Pinero,Nikolaos Pyrsopoulos,Sophie Restellini,Gustavo Romero,Marco Sacco,Tiago Sevá-Pereira,Macarena Simón-Talero,Do Seon Song,Ki Tae Suk,Hans Van Vlierberghe,Sun Young Yim,E.L. Yoon,Giacomo Zaccherini +70 more
TL;DR: Differences in the prevalence of MDR bacterial infections in different global regions indicate the need for different empirical antibiotic strategies in different continents and countries.
References
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The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
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Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology.
Roberto M. Lang,Michelle Bierig,Richard B. Devereux,Frank A. Flachskampf,Elyse Foster,Patricia A. Pellikka,Michael H. Picard,Mary J. Roman,James B. Seward,Jack S. Shanewise,Scott D. Solomon,Kirk T. Spencer,Martin St. John Sutton,William J. Stewart +13 more
TL;DR: Members of the Chamber Quantification Writing Group are: Roberto M. Lang, MD, Fase, Michelle Bierig, MPH, RDCS, FASE, Richard B. Devereux,MD, Frank A. Flachskampf, MD and Elyse Foster, MD.
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Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance
A-P Magiorakos,Arjun Srinivasan,R B Carey,Yehuda Carmeli,Matthew E. Falagas,Matthew E. Falagas,Christian G. Giske,Stéphan Juergen Harbarth,Janet F. Hindler,Gunnar Kahlmeter,Barbro Olsson-Liljequist,David L. Paterson,Louis B. Rice,John Stelling,Marc Struelens,Alkiviadis Vatopoulos,J T Weber,Dominique L Monnet +17 more
TL;DR: A group of international experts came together through a joint initiative by the European Centre for Disease Prevention and Control and the Centers for Disease Control and Prevention, to create a standardized international terminology with which to describe acquired resistance profiles in Staphylococcus aureus, Enterococcus spp.
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KDIGO clinical practice guidelines for acute kidney injury.
TL;DR: The guidelines focused on 4 key domains: (1) AKI definition, (2) prevention and treatment of AKI, (3) contrastinduced AKI (CI-AKI) and (4) dialysis interventions for the treatment ofAKI.
Journal ArticleDOI
Acute Kidney Injury Network: Report of an Initiative to Improve Outcomes in Acute Kidney Injury
Ravindra L. Mehta,John A. Kellum,Sudhir V. Shah,Bruce A. Molitoris,Claudio Ronco,David G. Warnock,Adeera Levin +6 more
TL;DR: The Acute Kidney Injury Network (AKI Network) as discussed by the authors is a multidisciplinary collaborative network focused on AKI, which was established to improve care for patients with or at risk for AKI.