Journal ArticleDOI
Effect of Anaesthetics on the Duration of Embolization of Platelet Thrombi formed in Injured Blood Vessels
G. V. R. Born,R. B. Philp +1 more
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White bodies form when platelets rapidly form a haemostatic plug outside the vessel and others adhere to its endothelial lining at the site of injury to form platelet clumps or ‘white bodies’ which embolize intermittently in the blood stream.Abstract:
WHEN an artery of the cerebral cortex of an anaesthetized rabbit is pinched with a pair of fine forceps so that it bleeds briefly, some platelets rapidly form a haemostatic plug outside the vessel and others adhere to its endothelial lining at the site of injury to form platelet clumps or ‘white bodies’ which embolize intermittently in the blood stream. The formation and embolization of white bodies may go on for several hours1–3.read more
Citations
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The preparation and use of the hamster cheek pouch for studies of the microcirculation
TL;DR: The cheek pouch is a useful microcirculatory preparation which has both advantages and disadvantages as outlined below and should be chosen for use with these characteristics in mind.
Journal ArticleDOI
Platelet aggregation in the cerebral microcirculation: effect of aspirin and other agents.
W I Rosenblum,F El-Sabban +1 more
TL;DR: In this paper, the authors found that platelet aggregation occurs only in the illuminated field and adhere to arteriolar and venular walls, but only when sodium fluorescein is first injected intravascularly to provide a light absorbing, heat generating target.
Journal ArticleDOI
Inhibition of gastric acid secretion in vitro by prostaglandin E1.
L Way,R P Durbin +1 more
TL;DR: Inhibition of epinephrine-induced lipolysis and vasopressin-induced changes in osmotic permeability by PGE1 have been attributed to interference with the accumulation of cyclic AMP induced by the respective hormone in the target organ or tissue.
Journal ArticleDOI
Platelet thrombus induced in vivo by filtered light and fluorescent dye in mesenteric microvessels of the rat.
M. Sato,Norio Ohshima +1 more
TL;DR: It was found that the combined conditions of light intensity and dye concentration at specific values had a critical effect on the rate of platelet aggregation and may suggest the dependence of the kinetics of intravascular thrombus formation on blood flow conditions.
Journal ArticleDOI
Effect of wall shear rate on thrombogenesis in microvessels of the rat mesentery.
M. Sato,Norio Ohshima +1 more
TL;DR: The role of hemodynamics on platelet thrombus formation was studied in venules and arterioles of the rat mesentery and its relation to blood flow was also examined in branched and curved microvessels.
References
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Journal ArticleDOI
Microscopical observations on the circulation of the blood in the cerebral cortex
Journal ArticleDOI
Influence of carbamic esters (urethanes) on experimental animal tumors.
Alexander Haddow,W. A. Sexton +1 more
TL;DR: Among these substances, the caryoclastic poisons of Dustin and his school, ethyl phenylcarbamate ('phenylurethane') (I) and its are among those reported as producing effects upon the mitotic cycle either in animals or plants.
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Leukaemia treated with urethane, compared with deep x-ray therapy.
Journal ArticleDOI
Inhibition by Adenosine and by 2-Chloroadenosine of the Formation and Embolization of Platelet Thrombi
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Strong inhibition by 2-chloroadenosine of the aggregation of blood platelets by adenosine diphosphate.
TL;DR: This work determined the inhibitory activities of 19 other substances, all related to adenosine, compared to the activity ofadenosine itself and found that the most potent of these four, with an activity of 5 per cent, was isoguanosine (2-oxy,6-amino purine riboside).