Effect of Δ9-tetrahydrocannabinol on monoamine oxidase activity of rat tissues in vivo
About: This article is published in Biochemical Pharmacology.The article was published on 1975-08-01. It has received 14 citations till now. The article focuses on the topics: Monoamine oxidase B & Monoamine oxidase.
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TL;DR: In vivo administration of Δ 9 -tetrahydrocannabinol to adult rats under acute conditions produced a dose-dependent stimulation of monoamine oxidase (MAO; monoamine: O 2 oxidoreductase (deaminating), EC 1.4.3.4) activity in blood platelets and in mitochondrial preparations of hypothalamus and heart, indicating that a characteristic interaction between membrane-bound MAO and Δ9 -THC can be disrupted by these chaotropic agents.
10 citations
TL;DR: I. RESEARCH ON DRUG METABOLISM CARRIED OUT by R.K. KATO and his ASSOCIATES.
Abstract: The study of drug metabolism in Japan was first carried out by Professor H. Tsukamoto and his associates in the early 1950s. They first characterized the urinary metabolites of barbiturates formed ...
4 citations
01 Jan 1982
TL;DR: The chemistry, pharmacology, and toxicology of cannabis were described in details in the Handbook of Experimental Pharmacology, Vol.
Abstract: The chemistry, pharmacology, and toxicology of cannabis were described in details in the Handbook of Experimental Pharmacology, Vol. 54/2 (1977). The purpose of this article is not to repeat that information, but to supplement it and present other points of view, as well as to summarize new aspects, e.g., the interaction of cannabis with other drugs. In addition, attempts to provide explanations for certain phenomena that cannot be definitely interpreted owing to contradictory findings (mostly resulting from the diverse methodologies used) are perhaps not only of heuristic value.
4 citations
01 Jan 1984
4 citations
References
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TL;DR: An investigation of the biochemical changes following experimental liver injury felt the need of a simple, rapid, and accurate method for determining the protein fractions in small amounts of serum and began with Kingsley’s biuret procedure.
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Journal Article•
2,490 citations
TL;DR: Administration of pure 1-δ9-tetrahydrocannabinol to mice had the following dose-dependent nzeurochemical and behavioral effects: a slight but significant increase in concentrations of 5-hydroxytryptamine in whole brain; a decrease in concentration of norepinephrine in brain after administration of low doses and an increase after high doses.
Abstract: Administration of pure 1-delta(9)-tetrahydrocannabinol to mice had the following dose-dependent nzeurochemical and behavioral effects: a slight but significant increase in concentrations of 5-hydroxytryptamine in whole brain; a decrease in concentration of norepinephrine in brain after administration of low doses and an increase after high doses; diminished spontaneous activity, mloderate hypothermnia, hypersetisitivity to tactile and auditory stimiuli, and ataxia after low doses; and sedation, pronounced hypothermia, and markedly diminished spon taneous activity and reactivity after high doses. The duration of the effects on body temperature and spontaneous activity correlated generally with the changes in brain amines. The characteristic changes in brain amines do not correspond exactly to those observed with other psychotropic drugs.
196 citations
TL;DR: Michael, S. E. & Charlwood, P. A. (1958).
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142 citations
TL;DR: The differences between the physicochemical properties of platelet MAO and isoenzymes from other anatomical sites suggests that the platelet enzyme is unlikely to provide a satisfactory index of in vivo activity in the whole organism.
105 citations