Effect of Edge Angle of Ink-Jet Printed Microdisk Lasers on Mode Shift Due to Protein Adsorption
03 Aug 2020-pp 9255993
TL;DR: In this article, a hyper branched polymer FC-V-50 based microdisk laser with different edge angles was fabricated by ink-jet printing method and the effect of edge angle on mode shift was investigated by monitoring the physical adsorption of BSA protein.
Abstract: Hyper branched polymer FC-V-50 based microdisk lasers with different edge angles were fabricated by ink-jet printing method. Then, effect of edge angle on mode shift was investigated by monitoring the physical adsorption of BSA protein. © 2020 The Author(s)
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TL;DR: The enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor are described, its current implementations and applications are reviewed, and its future possibilities are discussed.
Abstract: Optical label-free detectors, such as the venerable surface plasmon resonance (SPR) sensor, are generally favored for their ability to obtain quantitative data on intermolecular binding. However, before the recent introduction of resonant microcavities that use whispering gallery mode (WGM) recirculation, sensitivity to single binding events had not materialized. Here we describe the enhancement mechanisms responsible for the extreme sensitivity of the WGM biosensor, review its current implementations and applications, and discuss its future possibilities.
1,621 citations
TL;DR: By serializing multiple disks on a single waveguide bus in a CMOS compatible process, this work describes a biosensor capable of multiplexed interrogation of biological samples and demonstrates their ability to detect the specific capture of biomolecules.
Abstract: Silicon photonic biosensors are highly attractive for multiplexed Lab-on-Chip systems. Here, we characterize the sensing performance of 3 µm TE-mode and 10 µm dual TE/TM-mode silicon photonic micro-disk resonators and demonstrate their ability to detect the specific capture of biomolecules. Our experimental results show sensitivities of 26 nm/RIU and 142 nm/RIU, and quality factors of 3.3x104 and 1.6x104 for the TE and TM modes, respectively. Additionally, we show that the large disks contain both TE and TM modes with differing sensing characteristics. Finally, by serializing multiple disks on a single waveguide bus in a CMOS compatible process, we demonstrate a biosensor capable of multiplexed interrogation of biological samples.
150 citations
TL;DR: A comprehensive investigation of real-time temperature-induced resonance shift cancellation for silicon wire based biosensor arrays is reported for the first time, and sensor arrays with a SU8 protective cladding are found to provide superior stability for measurements involving long time scales.
Abstract: A comprehensive investigation of real-time temperature-induced resonance shift cancellation for silicon wire based biosensor arrays is reported for the first time. A reference resonator, protected by either a SU8 or SiO(2) cladding layer, is used to track temperature changes. The temperature dependence of resonators in aqueous solutions, pertinent to biosensing applications, is measured under steady-state conditions and the operating parameters influencing these properties are discussed. Real-time measurements show that the reference resonator resonances reflect the temperature changes without noticeable time delay, enabling effective cancellation of temperature-induced shifts. Binding between complementary IgG protein pairs is monitored over 4 orders of magnitude dynamic range down to a concentration of 20 pM, demonstrating a resolvable mass of 40 attograms. Reactions are measured over time periods as long as 3 hours with high stability, showing a scatter corresponding to a fluid refractive index fluctuation of ± 4 × 10(-6) in the baseline data. Sensor arrays with a SU8 protective cladding are easy to fabricate, while oxide cladding is found to provide superior stability for measurements involving long time scales.
101 citations
TL;DR: These measurements represent the first demonstration of biosensing in active WGM devices with simultaneous compensation of both photobleaching and temperature drift, and are believed to be the best of their knowledge.
Abstract: Whispering-gallery mode (WGM) microdisk lasers show great potential for highly sensitive label-free detection in large-scale sensor arrays. However, when used in practical applications under normal ambient conditions, these devices suffer from temperature fluctuations and photobleaching. Here we demonstrate that these challenges can be overcome by a novel referencing scheme that allows for simultaneous compensation of temperature drift and photobleaching. The technique relies on reference structures protected by locally dispensed passivation materials, and can be scaled to extended arrays of hundreds of devices. We prove the viability of the concept in a series of experiments, demonstrating robust and sensitive label-free detection over a wide range of constant or continuously varying temperatures. To the best of our knowledge, these measurements represent the first demonstration of biosensing in active WGM devices with simultaneous compensation of both photobleaching and temperature drift.
34 citations
TL;DR: An extreme ultra-low lasing threshold is demonstrated from full-polymeric fundamental microdisk cavities fabricated by a novel fabrication method, the ink-jet printing method, which is much simpler and easier than previous methods such as lithography.
Abstract: Extreme ultra-low lasing threshold of full-polymeric fundamental microdisk printed with room-temperature atmospheric ink-jet technique
24 citations