Effect of estrogen replacement on temporomandibular joint remodeling in ovariectomized rats.

doi:10.1016/S0278-2391(00)90337-9

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Effect of estrogen replacement on temporomandibular joint remodeling in ovariectomized rats.

Journal Article•DOI•

Effect of estrogen replacement on temporomandibular joint remodeling in ovariectomized rats.

Tadashi Yasuoka¹, Masahito Nakashima¹, Takashi Okuda¹, Norichika Tatematsu¹•Institutions (1)

Gifu University¹

01 Feb 2000-Journal of Oral and Maxillofacial Surgery (Elsevier)-Vol. 58, Iss: 2, pp 189-196

TL;DR: Estrogen in a physiologic concentration may play an important role in TMJ remodeling and Progesterone may be indispensable for remodeling, particularly contributing to morphogenesis.

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About: This article is published in Journal of Oral and Maxillofacial Surgery.The article was published on 2000-02-01. It has received 97 citations till now. The article focuses on the topics: Ovariectomized rat & Bone remodeling.

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Journal Article•DOI•

Modulation of pain by estrogens.

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Rebecca M. Craft¹•Institutions (1)

Washington State University¹

01 Nov 2007-Pain

TL;DR: A more complete understanding of the myriad ways that estrogens can ameliorate vs. facilitate pain will enable us to better prevent and treat pain in both women and men.

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Abstract: It has become increasingly apparent that women suffer a disproportionate amount of pain during their lifetime compared to men. Over the past 15 years, a growing number of studies have suggested a variety of causes for this sex difference, from cellular to psychosocial levels of analysis. From a biological perspective, sexual differentiation of pain appears to occur similarly to sexual differentiation of other phenomena: it results in large part from organizational and activational effects of gonadal steroid hormones. The focus of this review is the activational effects of a single group of ovarian hormones, the estrogens, on pain in humans and animals. The effects of estrogens (estradiol being the most commonly examined) on experimentally induced acute pain vs. clinical pain are summarized. For clinical pain, the review is limited to a few syndromes for which there is considerable evidence for estrogenic involvement: migraine, temporomandibular disorder (TMD) and arthritis. Because estrogens can modulate the function of the nervous, immune, skeletal, and cardiovascular systems, estrogenic modulation of pain is an exceedingly complex, multi-faceted phenomenon, with estrogens producing both pro- and antinociceptive effects that depend on the extent to which each of these systems of the body is involved in a particular type of pain. Forging a more complete understanding of the myriad ways that estrogens can ameliorate vs. facilitate pain will enable us to better prevent and treat pain in both women and men.

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339 citations

Cites background from "Effect of estrogen replacement on t..."

...[115] Yasuoka T, Nakashima M, Okuda T, Tatematsu N....
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...Ovarian hormone depletion via ovariectomy in rats has been shown to result in maladaptive changes to TMJ structure, which are prevented by estradiol replacement [115]....
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Journal Article•DOI•

Temporomandibular disorders and hormones in women.

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Michelle P. Warren¹, Joanna L. Fried•Institutions (1)

Columbia University¹

01 Jan 2001-Cells Tissues Organs

TL;DR: The hypothesis that the overwhelming majority of patients treated for temporomandibular disorders are women is used and the available literature is used to examine the role of hormones in TMD.

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Abstract: Temporomandibular disorders (TMD) are loosely defined as an assorted set of clinical conditions, characterized by pain and dysfunction of the masticatory system. Pain in the masticatory muscles, in th

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274 citations

Cites background from "Effect of estrogen replacement on t..."

...In 1996, one study found that steroid sex hormones have an effect on the collagen and protein content of the TMJ disc [Abubaker et al., 1996]....
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...Further, in a very limited study of the TMJ specimens of 14 women and 8 men, estrogen and progesterone receptors were found in varying frequencies in both symptomatic and asymptomatic women and men [Abubaker et al., 1993]....
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...However, the authors of a similar 1993 study came to the conclusion that TMD may not be hormonally modulated by estrogens, when the study of 14 human TMJ samples revealed no significant presence of estrogen receptors in the tissue [Campbell et al., 1993]....
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...An avenue which merits further exploration combines biological and behavioral factors; a 1999 study identified Chlamydia trachomatis in the TMJ. Thirty-nine percent (all women) of 30 TMD patients (29 women, 2 men) had C. trachomatis present in TMJ tissue....
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...Pain in the masticatory muscles, in the temporomandibular joint (TMJ), and in associated hard and soft tissues, limitation in jaw function, and sound in the TMJ are common symptoms [Kuttila et al., 1998]....
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Journal Article•DOI•

Evaluation of bone changes in the temporomandibular joint using cone beam CT.

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ML dos Anjos Pontual¹, Jsl Freire, Jmn Barbosa, Mag Frazão, A dos Anjos Pontual¹, M M Fonseca da Silveira - Show less +2 more•Institutions (1)

Federal University of Paraíba¹

01 Jan 2012-Dentomaxillofacial Radiology

TL;DR: There is a high prevalence of degenerative bone alteration in TMJs, which is more frequent in women and mostly located in the condyle, which increases with age and there is no correlation between condylar mobility and the presence of degeneratives bony changes in TMJ.

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Abstract: Objective: The aim of this study was to assess bone changes and mobility in temporomandibular joints (TMJs) using cone beam CT (CBCT) in a population sample in Recife, PE, Brazil. Methods: The TMJ images of patients treated by a radiologist at a private dental radiology service over a period of 1 year were retrieved from the computer database and assessed using a computer with a 21-inch monitor and the iCAT Cone Beam 3D Dental Imaging System Workstation program (Imaging Sciences International, Hatfield, PA). The Pearson x 2 test was used to analyse the differences in percentage of bone changes among the categories of mobility (p # 0.05). The McNemar test was used to compare the presence of bone changes in TMJs on the right and left sides (p # 0.05). Results: An adjusted logistic regression model was used to assess the effect of age and gender on the occurrence of bone changes (p # 0.05). Bone changes were present in 227 (71%) patients. Age group and gender showed a statistically significant association with presence of bone changes (p # 0.05). There was no significant difference between the right and left sides (p 5 0.556) and in condylar mobility (p 5 0.925) with regard to the presence of degenerative bone changes. Conclusions: There is a high prevalence of degenerative bone alteration in TMJs, which is more frequent in women and mostly located in the condyle. The prevalence of degenerative bone changes increases with age. There is no correlation between condylar mobility and the presence of degenerative bony changes in TMJs. Dentomaxillofacial Radiology (2012) 41, 24–29. doi: 10.1259/dmfr/17815139

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153 citations

Cites background from "Effect of estrogen replacement on t..."

...CBCT has been shown to be efficient in the diagnosis of several bone changes that affect the TMJ.7 However, there are few studies on the prevalence of bone changes in TMJ, particularly using CT....
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...The greater occurrence in women may be explained by the hormonal influences of oestrogen and prolactin, which may exacerbate degradation of cartilage and articular bone in addition to stimulating a series of immunological responses in the TMJ.(12,17) Nevertheless, Cruzoé-Rebello et al(18) observed that both men and women share the same a b c...
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...In conclusion, women have a greater predisposition to degenerative bone changes in the TMJ....
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...Several radiographic methods are used to assess degenerative bone changes that affect the TMJ....
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...The greater occurrence in women may be explained by the hormonal influences of oestrogen and prolactin, which may exacerbate degradation of cartilage and articular bone in addition to stimulating a series of immunological responses in the TMJ.12,17 Nevertheless, Cruzoé-Rebello et al18 observed that both men and women share the same a b c Figure 2 Lateral slices of the temporomandibular joint (TMJ) in maximum opening....
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Journal Article•DOI•

Progressive condylar resorption after mandibular advancement.

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Tadaharu Kobayashi¹, Naoya Izumi¹, Taku Kojima¹, Naoko Sakagami¹, Isao Saito¹, Chikara Saito¹ - Show less +2 more•Institutions (1)

Niigata University¹

01 Mar 2012-British Journal of Oral & Maxillofacial Surgery

TL;DR: The findings in preoperative cephalograms indicated that the patients had clockwise rotation of the mandible and retrognathism because of a small SNB angle, a wide mandibular plane angle, and a "minus" value for inclination of the ramus, and careful attention should be paid to postoperative mechanical loading on the TMJ in high-risk patients.

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Abstract: Progressive condylar resorption is an irreversible complication and a factor in the development of late skeletal relapse after orthognathic surgery. We have evaluated cephalometric characteristics, signs and symptoms in the temporomandibular joint (TMJ), and surgical factors in six patients (one man and five women) who developed it after orthognathic surgery. The findings in preoperative cephalograms indicated that the patients had clockwise rotation of the mandible and retrognathism because of a small SNB angle, a wide mandibular plane angle, and a "minus" value for inclination of the ramus. There were erosions or deformities of the condyles, or both, on three-dimensional computed tomography (CT) taken before treatment. The mean (SD) anterior movement of the mandible at operation was 12.1 (3.9)mm and the mean relapse was -6.4 (2.5)mm. The mean change in posterior facial height was 4.5 (2.1)mm at operation and the mean relapse was -5.3 (1.8)mm. Two patients had click, or pain, or both, preoperatively. The click disappeared in one patient postoperatively, but one of the patients who had been symptom-free developed crepitus postoperatively. In the classified resorption pattern, posterior-superior bone loss was seen in three cases, anterior-superior bone loss in two, and superior bone loss in one. Progressive condylar resorption after orthognathic surgery is multifactorial, and some of the risk factors are inter-related. Patients with clockwise rotation of the mandible and retrognathism in preoperative cephalograms; erosion, or deformity of the condyle, or both, on preoperative CT; and wide mandibular advancement and counterclockwise rotation of the mandibular proximal segment at operation, seemed to be at risk. The mandible should therefore be advanced only when the condyles are stable on radiographs, and careful attention should be paid to postoperative mechanical loading on the TMJ in high-risk patients.

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121 citations

Journal Article•DOI•

Temporomandibular joint osteoarthritis: cone beam computed tomography findings, clinical features, and correlations.

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S. Cömert Kiliç¹, Nihat Kiliç², Muhammed Akif Sümbüllü²•Institutions (2)

Turkish Ministry of Health¹, Atatürk University²

01 Oct 2015-International Journal of Oral and Maxillofacial Surgery

TL;DR: Condylar erosion, flattening, osteophytes, pain, joint sounds, reduced jaw movements, and worsened mastication were common findings in TMJ-OA in the present study.

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94 citations

Cites background from "Effect of estrogen replacement on t..."

...Oestrogen could aggravate TMJ-OA, which may be an important mechanism underlying the sexual dimorphism of TMJ-OA.(8) The age of the study sample ranged from 14 years to 73 years, with a mean age of 30....
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...According to the literature, this hormonal distinction may exacerbate the degeneration of cartilage and articular bone in the TMJ and explains the higher proportion of females than males with TMJ-OA.(8) A potential role of the sex hormones oestrogen and prolactin in the development of osteoarthritis has been suggested....
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Journal Article•DOI•

Skeletal Effects of Estrogen

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Russell T. Turner¹, Riggs Bl¹, Thomas C. Spelsberg¹•Institutions (1)

University of Rochester¹

01 Jun 1994-Endocrine Reviews

TL;DR: Estrogen appears to be the most important sex steroid in preventing osteoporosis in women and is the subject of this review.

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Abstract: BONE differs from reproductive tissues in that many aspects of skeletal growth, turnover, and function occur in the absence of gonadal hormones. Nevertheless, sex steroids have an important impact on bone physiology: they participate in the sexual dimorphism of the skeleton, play a role in maintenance of mineral homeostasis during reproduction, and are essential to maintaining bone balance in adults. Insufficient levels of certain sex steroids predispose the human skeleton to bone loss and to osteoporotic fractures. Estrogen appears to be the most important sex steroid in preventing osteoporosis in women and is the subject of this review. Serious difficulties must be overcome to understand the action of estrogen on mineralized tissues. The skeleton is heterogeneous and contains many cell types. The cells that synthesize (osteoblasts), lie within (osteocytes), and degrade (osteoclasts) bone matrix are present in small numbers, are difficult to isolate as pure populations, and probably do not proliferate.

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779 citations

Book•

Basic and Clinical Endocrinology

[...]

Francis S. Greenspan

01 Oct 1990

TL;DR: Basic & Clinical Endocrinology, fourth edition superbly reviews contributions of molecular biology to endocrinology and the practical implications of these advances and combines basic pathophysiology with practical clinical applications.

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Abstract: Basic & Clinical Endocrinology, fourth edition superbly reviews contributions of molecular biology to endocrinology and the practical implications of these advances. An entirely new chapter on "General Concepts of Endocrinology" summarizes hormone actions and in enactions and their molecular basis. Every chapter includes advances in molecular biology and the diagnosis and management of the various syndromes. This accessible text is a thorough overview of all aspects of endocrinology. Features: summarizes molecular mechanisms in synthesis, secretion, and action of hormones; individual endocrine syndrome chapters analyze current diagnostic methods; combines basic pathophysiology with practical clinical applications; contributions by leading physician-researchers; abundantly illustrated; and useful appendix of normal values for endocrine tests in both conventional and SI units.

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491 citations

Journal Article•DOI•

Quantitative analysis of temporomandibular joint adaptations to protrusive function.

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James A. McNamara¹, David S. Carlson¹•Institutions (1)

University of Michigan¹

01 Dec 1979-American Journal of Orthodontics

281 citations

Journal Article•DOI•

Quantum concept of bone remodeling and turnover: implications for the pathogenesis of osteoporosis.

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A. M. Parfitt¹•Institutions (1)

Henry Ford Hospital¹

24 Aug 1979-Calcified Tissue International

TL;DR: The concept is that bone turnover occurs in anatomically discrete loci, within which remodeling activity lasts for about 4-6 months, and the specialized group of cells which accomplish turnover as a bone remodeling unit (BRU) and the end product of the activity of these cells as a Bone structural unit (BSU).

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Abstract: A fundamental concept of physics is that energy is transferred not continuously but only in discrete steps, or quanta. About 15 years ago Harold Frost [1] proposed a similar concept for bone remodeling; like many revolutionary new ideas the concept was initially ridiculed, and only in the last few years has it gathered more than a handful of adherents. Briefly stated, the concept is that bone turnover occurs in anatomically discrete loci, within which remodeling activity lasts for about 4-6 months. A small piece of existing bone is removed by osteoclastic resorption, and within the cavity so formed new bone is laid down until the defect is more or less completely repaired [2]. Frost refers to one quantum of remodeling activity as a BMU, initials which at various times have stood for basic multicellular unit and basic metabolizing unit. To avoid this ambiguity, we will refer to the specialized group of cells which accomplish turnover as a bone remodeling unit (BRU) [3], and the end product of the activity of these cells as a bone structural unit (BSU) [4]. Histologists have long recognized that the skeleton is constructed of many small elements of bone made at different times. As bricks are joined together by mortar, so the BSUs are joined together by a highly mineralized but collagen-free connective tissue. With toluidine blue or other appropriate staining, this is visible in the two-dimensional world of the histologic section as a cement line--in three-dimensional reality, a cement plane or surface. Within the cortex the BSU is the familiar haversian system or osteon [2]. On the trabecular surface the BSU is shaped somewhat like a shallow saucer, about 50 ~m in depth at the center and several hundred micrometers across [5], which can be referred to as a trabecular osteon. The demarcation between adjacent BSUs can be recognized not only by the

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248 citations

Journal Article•DOI•

Tissue responses to degenerative changes in the temporomandibular joint: A review

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Boudewijn Stegenga¹, Lambert G.M. de Bont¹, Geert Boering¹, Jan D. van Willigen¹•Institutions (1)

University of Groningen¹

01 Oct 1991-Journal of Oral and Maxillofacial Surgery

TL;DR: Structural changes associated with osteoarthrosis are described and related to common signs and symptoms of craniomandibular dysfunction, such as clicking, locking and instability, pain and tenderness, restricted ranges of mandibular motion, crepitation, deformity, muscle wasting, and changes of occlusion.

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229 citations