Effect of Fluorouracil, Leucovorin, and Oxaliplatin With or Without Onartuzumab in HER2-Negative, MET-Positive Gastroesophageal Adenocarcinoma: The METGastric Randomized Clinical Trial.
Citations
858 citations
690 citations
242 citations
199 citations
166 citations
Cites background from "Effect of Fluorouracil, Leucovorin,..."
...MET antibodies onartuzumab III MET-positive NSCLC b Erlotinib ± onartumumab NCT01456325 [212] onartuzumab III HER2(-)/MET(+)-GEC c mFOLFOX6 ± onartumumab NCT01662869 [213]...
[...]
References
24,414 citations
14,211 citations
12,684 citations
5,679 citations
"Effect of Fluorouracil, Leucovorin,..." refers background in this paper
...Specifically, as observed in the ToGA and AVAGAST studies (Bang et al. 2010; Ohtsu et al. 2011), Asian patients with advanced GEC more commonly receive second and further lines of therapy, more frequently have a prior history of gastrectomy, present with a higher proportion of non-measurable…...
[...]
...3 Prior Gastrectomy Patients will be stratified based on history of prior gastric resection (gastrectomy) because this has been shown to be a highly influential prognostic factor associated with longer OS in studies such as ToGA and AVAGAST (Bang et al. 2010; Ohtsu et al. 2011; Sawaki et al. 2011)....
[...]
...In ToGA, the addition of trastuzumab to chemotherapy was found to be superior to chemotherapy alone in terms of OS, the primary endpoint, in patients with HER2-positive advanced gastric or GEJ cancer (Bang et al. 2010)....
[...]
...Specifically, as observed in the ToGA and AVAGAST studies (Bang et al. 2010; Ohtsu et al. 2011), Asian patients with advanced GEC more commonly receive second and further lines of therapy, more frequently have a prior history of gastrectomy, present with a higher proportion of non-measurable disease, and have liver metastases or proximal or gastroesophageal junction tumors less frequently....
[...]
5,568 citations
"Effect of Fluorouracil, Leucovorin,..." refers background in this paper
...The histology of GEC falls into two broad subtypes based on microscopic features observed in gastric tumors, namely intestinal or diffuse, according to Lauren’s classification (Lauren 1965)....
[...]