Effect of Genome Size on AAV Vector Packaging
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...Commonly used delivery systems based on lentiviral and ad- eno-associated viral (AAV) vectors have limited packaging ca- pacity (Kumar et al., 2001; Wu et al., 2010), which renders it challenging for incorporation of Cas9 along with sgRNA expres- sion cassettes and necessary genetic elements (i.e.,…...
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...…Hughes Medical Institute, Chevy Chase, MD 20815, USA 13Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA 14Co-first authors *Correspondence: sharppa@mit.edu (P.A.S.), zhang@broadinstitute.org (F.Z.) http://dx.doi.org/10.1016/j.cell.2014.09.014...
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Cites background from "Effect of Genome Size on AAV Vector..."
...However, AAV has a packaging limit of 4.5 kb of foreign DNA (Wu et al., 2010)....
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Additional excerpts
...sapiens 580 (1-250) + GGSG linker + (500-580) 335 163-250(91): PHD2...
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References
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