Effect of geometry on drug release from 3D printed tablets.
Citations
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544 citations
Cites background from "Effect of geometry on drug release ..."
...Strategies for increasing dissolution rates include printing high-surface-area shapes [44] and printing amorphous dispersions by hot melt extrusion [7,30]....
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...Freezing of a low-melting binder • Printing SODFs with all but one side covered by an impermeable membrane so that the dissolvable portion maintains a constantsurface area during drug release [94], • Stacking six ormore distinct layers in a single product formulti-phasic release [46,95], and • Printing toroidal SODFs that achieve near-zero-order release [44]....
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498 citations
Cites background or methods from "Effect of geometry on drug release ..."
...…advantages of good mechanical strength (Chia and Wu, 2015), and the printed dosage forms can be designed to achieve different releases profile by modifying the infill percentage, 3D model design or surface area of the formulation (Goyanes et al., 2014; Goyanes et al., 2015e; Goyanes et al., 2015f)....
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...The 3D printed tablets were tested in the dynamic in vitro model, which simulates gastric and intestinal conditions of the GI tract (Goyanes et al., 2015d)....
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...In a previous study, approximately 50% of the model drug 4-aminosalicylic acid (4-ASA) was degraded during 3D printing (Goyanes et al., 2015a)....
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...…capacity and ionic composition of the physiological bicarbonate buffers also closely match the buffer capacities of the intestinal fluids collected from different parts of the gut in humans (Fadda et al., 2009; Goyanes et al., 2015c; Goyanes et al., 2015d; Liu et al., 2011; Varum et al., 2013)....
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...In contrast, when preparing the filaments for FDM printer, drug loading was sometimes lower than expected due to the adherence of powered drug to the walls of the containers during extrusion or irregular extrusion of components (Goyanes et al., 2015b)....
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479 citations
Cites background or methods from "Effect of geometry on drug release ..."
...Indeed, numerous pharmaceutical companies have shown growing interest in the HME process to develop different dosage forms such as tablets (e.g. Kaletra® [Abott]), implants (e.g. Ozurdex® [Allergan]) and medical devices (Nuvaring® [Mercks]) [Goyanes et al., 2015b]....
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...In another study, Goyanes and coworkers showed that FDM allowed dissolution release profiles to be modified according to the geometry of the dosage form [Goyanes et al., 2015b]....
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...Similar impregnation essays were performed on fluorescein, 5-aminosalicylic acid (5-ASA, mesalazine) and 4-aminosalicylic acid (4-ASA), with yields of 0.29, 0.24 and 0.06% w/w, respectively [Goyanes et al., 2014, 2015a]....
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...…to reprint the figure has been obtained) Figure 12: 3D representation and images of the 3D geometries printed using the FDM process [Adapted from Goyanes et al., 2015b] (permission to reprint the figure has been) obtained Figure 1 Figure 2 0 10 20 30 40 50 60 70 80 90 100 N u m b e r o f ar…...
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...…that must be controlled during an FDM process are the infill density, the speed of the extruder, the height of the layers and the temperature of both the nozzle and the building plate [Goyanes et al., 2014; Goyanes et al., 2015a; Goyanes et al. 2015b; Pietrzak et al., 2015 Skowyra et al., 2015]....
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References
790 citations
"Effect of geometry on drug release ..." refers methods in this paper
...Several research groups have demonstrated HME processes as a viable method to prepare a wide range of accepted pharmaceutical drug delivery systems, including granules, pellets, transdermal patches, transmucosal films systems and implants (Breitenbach, 2002; Crowley et al., 2007; Fonteyne et al., 2013)....
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771 citations
"Effect of geometry on drug release ..." refers methods in this paper
...Several research groups have demonstrated HME processes as a viable method to prepare a wide range of accepted pharmaceutical drug delivery systems, including granules, pellets, transdermal patches, transmucosal films systems and implants (Breitenbach, 2002; Crowley et al., 2007; Fonteyne et al., 2013)....
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450 citations
"Effect of geometry on drug release ..." refers background in this paper
...fluorescein (Goyanes et al., 2014), aminosalicylates (Goyanes et al....
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...This principle has been demonstrated, for example, to tablets containing fluorescein (Goyanes et al., 2014), 4-aminosalicylate and 5-aminosalicylate (Goyanes et al....
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...Goyanes et al. / International Journal of Pharmaceutics xxx (2015) xxx–xxx G Model IJP 14860 No....
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444 citations
Additional excerpts
..., 2014), aminosalicylates (Goyanes et al., 2015) and herein paracetamol....
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..., 2014), 4-aminosalicylate and 5-aminosalicylate (Goyanes et al., 2015) and prednisolone (Skowyra et al....
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424 citations
Additional excerpts
..., 2015) and prednisolone (Skowyra et al., 2015)....
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