Journal ArticleDOI
Effect of graft-versus-host disease prophylaxis on 3-year disease-free survival in recipients of unrelated donor bone marrow (T-cell Depletion Trial): a multi-centre, randomised phase II–III trial
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TLDR
A multi-centre, randomised trial was undertaken to determine the effects of ex-vivo T-cell depletion versus methotrexate and cyclosporine immunosuppression on 3-year disease-free survival.About:
This article is published in The Lancet.The article was published on 2005-08-27. It has received 226 citations till now. The article focuses on the topics: Transplantation & Survival rate.read more
Citations
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Journal ArticleDOI
Graft-versus-host disease
TL;DR: The understanding of the risk factors and causes of GHVD, the cellular and cytokine networks implicated in its pathophysiology, and current strategies to prevent and treat the disease are reviewed.
Journal ArticleDOI
Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial
Jürgen Finke,Wolfgang Bethge,Claudia Schmoor,Hellmut Ottinger,Matthias Stelljes,Axel R. Zander,Liisa Volin,Tapani Ruutu,Dominik Heim,Rainer Schwerdtfeger,Karin Kolbe,Jiri Mayer,Johan Maertens,Werner Linkesch,Ernst Holler,Vladimir Koza,Martin Bornhäuser,Hermann Einsele,Hans-Jochem Kolb,Hartmut Bertz,Matthias Egger,Olga Grishina,Gérard Socié +22 more
TL;DR: The addition of ATG-F to GVHD prophylaxis with ciclosporin and methotrexate resulted in decreased incidence of acute and chronic GV HD without an increase in relapse or non-relapse mortality, and without compromising overall survival.
Journal ArticleDOI
IFN‐γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease
David Polchert,Justin Sobinsky,G. W. Douglas,Martha Kidd,Ada Moadsiri,Eduardo Reina,Kristyn Genrich,Swati Mehrotra,Suman Setty,Brett Smith,Amelia Bartholomew +10 more
TL;DR: It is shown that bone marrow‐isolated MSC can suppress the development of GVHD if given after donor T cell recognition of antigen, and activated MSC could prevent GV HD mortality when given at the time of bone marrow transplantation.
Journal ArticleDOI
Immunobiology of Allogeneic Hematopoietic Stem Cell Transplantation
TL;DR: Current understanding of some of the issues that affect the success of allogeneic HSCT are reviewed, including host-versus-graft (HVG) reactions, graft-versu-host disease (GVHD), graft-Versus-tumor (GVT) activity, and restoration of functional immunity to prevent transplant-related opportunistic infections.
Journal ArticleDOI
High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease.
Leo Luznik,Javier Bolaños-Meade,Marianna Zahurak,Allen R. Chen,B. Douglas Smith,Robert A. Brodsky,Carol Ann Huff,Ivan Borrello,William Matsui,Jonathan D. Powell,Yvette L. Kasamon,Steven N. Goodman,Allan D. Hess,Hyam I. Levitsky,Richard F. Ambinder,Richard J. Jones,Ephraim J. Fuchs +16 more
TL;DR: High-dose posttransplantation cyclophosphamide is an effective single-agent prophylaxis of acute and chronic GVHD after BuCy conditioning and HLA-matched BMT (clinicaltrials.gov no. NCT00134017).
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
X. On the criterion that a given system of deviations from the probable in the case of a correlated system of variables is such that it can be reasonably supposed to have arisen from random sampling
TL;DR: In this article, a system of deviations from the means of n variables with standard deviations σ 1, σ 2 σ σ n and with correlations r12, r13, r23, r n −1,n.
Journal ArticleDOI
Estimation of failure probabilities in the presence of competing risks: new representations of old estimators
Ted Gooley,Ted Gooley,Wendy M. Leisenring,Wendy M. Leisenring,John Crowley,John Crowley,Barry E. Storer,Barry E. Storer +7 more
TL;DR: A representation of each estimate in a manner not ordinarily seen is presented, each representation utilizing the concept of censored observations being 'redistributed to the right' to allow a more intuitive understanding of each estimates.
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National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease
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HLA-Haploidentical Bone Marrow Transplantation for Hematologic Malignancies Using Nonmyeloablative Conditioning and High-Dose, Posttransplantation Cyclophosphamide
Leo Luznik,Paul O'Donnell,Paul O'Donnell,Heather J. Symons,Allen R. Chen,M. Susan Leffell,Marianna Zahurak,Ted Gooley,Ted Gooley,S Piantadosi,Michele Kaup,Richard F. Ambinder,Carol Ann Huff,William Matsui,Javier Bolaños-Meade,Ivan Borrello,Jonathan D. Powell,Elizabeth Harrington,Sandy Warnock,Mary E.D. Flowers,Mary E.D. Flowers,Robert A. Brodsky,Brenda M. Sandmaier,Brenda M. Sandmaier,Rainer Storb,Rainer Storb,Richard J. Jones,Ephraim J. Fuchs +27 more