Journal ArticleDOI
Effect of Irrigants on the Survival of Human Stem Cells of the Apical Papilla in a Platelet-rich Plasma Scaffold in Human Root Tips
Ernesto G. Trevino,Amol N. Patwardhan,Michael A. Henry,Griffin M. Perry,Nicholas F. Dybdal-Hargreaves,Kenneth M. Hargreaves,Anibal R. Diogenes +6 more
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TLDR
It is suggested that irrigants alone greatly affect the survivability of STRO-1-enriched SCAP within the root canal environment and that inclusion of EDTA in irrigation protocols might be beneficial in regenerative procedures.About:
This article is published in Journal of Endodontics.The article was published on 2011-08-01. It has received 319 citations till now. The article focuses on the topics: Root canal & Regenerative endodontics.read more
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Journal ArticleDOI
Direct effect of intracanal medicaments on survival of stem cells of the apical papilla
TL;DR: The data show that high concentrations of antibiotics have a detrimental effect on SCAP survival, whereas lower concentrations as well as Ca(OH)(2) at all tested concentrations are conducive withSCAP survival and proliferation.
Journal ArticleDOI
Treatment options: biological basis of regenerative endodontic procedures
TL;DR: The current literature supporting a biological rationale for considering regenerative endodontic treatment procedures in treating the immature permanent tooth with pulp necrosis is summarized.
Journal ArticleDOI
Dentin Conditioning Codetermines Cell Fate in Regenerative Endodontics
Kerstin M. Galler,Rena N. D'Souza,Marianne Federlin,Adriana Cavender,Jeffrey D. Hartgerink,Stephanie Hecker,Gottfried Schmalz +6 more
TL;DR: Dentin conditioning considerably influences DPSC fate when seeded in close proximity to dentin, and this information might be critical for optimized strategic planning for future regenerative endodontic treatment.
Journal ArticleDOI
Concentration-dependent effect of sodium hypochlorite on stem cells of apical papilla survival and differentiation.
David E. Martin,José Flávio Affonso de Almeida,Michael A. Henry,Zin Z. Khaing,Christine E. Schmidt,Fabricio B. Teixeira,Anibal R. Diogenes +6 more
TL;DR: The results suggest that dentin conditioning with high concentrations of NaOCl has a profound negative effect on the survival and differentiation of SCAPs, however, this effect can be prevented with the use of 1.5%NaOCl followed by 17% EDTA.
Journal ArticleDOI
An update on clinical regenerative endodontics
TL;DR: This review summarizes the evolution of Regenerative endodontic procedures while presenting recent advances, including treatment protocol modifications based on translational studies and future bioengineering approaches.
References
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Journal ArticleDOI
Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine
TL;DR: This article will review the isolation and characterization of the properties of different dental MSC-like populations in comparison with those of other MSCs, such as BMMSCs.
Journal ArticleDOI
Platelet-rich plasma: evidence to support its use
TL;DR: Not all currently marketed PRP devices are qual; some do not concentrate viably active platelets n sufficient numbers to produce a healing enhance- herefore, the term PRP is preferred to autologous latelet gel, plasma-rich growth factors (PRGFs), or a ere autOLOGous platelet concentrate.
Journal ArticleDOI
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
Wataru Sonoyama,Wataru Sonoyama,Yi Liu,Dianji Fang,Takayoshi Yamaza,Byoung Moo Seo,Chunmei Zhang,He Liu,Stan Gronthos,Cun-Yu Wang,Songtao Shi,Songlin Wang +11 more
TL;DR: This work transplanted both human SCAP and periodontal ligament stem cells to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function and recovery of tooth strength and appearance.
Journal ArticleDOI
Characterization of the Apical Papilla and Its Residing Stem Cells from Human Immature Permanent Teeth: A Pilot Study
Wataru Sonoyama,Yi Liu,Takayoshi Yamaza,Rocky S. Tuan,Songlin Wang,Songtao Shi,George T.-J. Huang +6 more
TL;DR: The apical papilla is distinctive to the pulp in terms of containing less cellular and vascular components than those in the pulp, and both SCAP and DPSCs were as potent in osteo/dentinogenic differentiation as MSCs from bone marrows, whereas they were weaker in adipogenic potential.
Journal ArticleDOI
Revascularization of Immature Permanent Teeth With Apical Periodontitis: New Treatment Protocol?
Francisco Banchs,Martin Trope +1 more
TL;DR: In this paper, a new technique was presented to revascularize immature permanent teeth with apical periodontitis, where the canal is disinfected with copious irrigation and a combination of three antibiotics.
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Revascularization of Immature Permanent Teeth With Apical Periodontitis: New Treatment Protocol?
Francisco Banchs,Martin Trope +1 more