Effect of KH-BaRoKer-SeongJangTang based on traditional medicine theory on longitudinal bone growth
Min-Ho Kim,Hyeonseok Jeong,Myungduek Park,Phil-Dong Moon +3 more
- Vol. 4, Iss: 2, pp 45-50
Reads0
Chats0
TLDR
Evaluated effects of KBS on bone growth suggest that KBS would be helpful to children who are in retard for their age through the elevation of IGF-I.Abstract:
KH-BaRoKer-SeongJangTang (KBS) is a recently developed formulation by using traditional drugs considering traditional medical theory of Oriental books such as ShinNongBonChoGyeong and JuRye, which has been used to improve the growth of child in Korea. Although KBS is usually prescribed to many children who are in retard for their age, its pharmacological effects have not been fully understood in experimental models. The aim of this study was to evaluate the effects of KBS on bone growth. Growth plate thickness and bone parameters such as bone volume/tissue volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), connection density (Conn.D), and total porosity were analyzed by means of microcomputed tomography. Serum insulin-like growth factor-I (IGF-I) levels were measured by enzyme-linked immunosorbent assay. Hepatic IGF-I mRNA expression was analyzed by real-time polymerase chain reaction. Phosphorylation of signal transducer and activator of transcription5 (STAT5) was investigated using Western blot analysis and immunohistochemistry. The thickness of growth plate was increased by KBS. BV/TV, Tb.Th, TbN, Conn.D, and total porosity were improved by KBS. Hepatic IGF-I mRNA and serum IGF-I levels were elevated by KBS. Phosphorylation of STAT5 was increased with administration of KBS. These results suggest that KBS would be helpful to children who are in retard for their age through the elevation of IGF-I.read more
Citations
More filters
Journal ArticleDOI
Glutamic acid ameliorates estrogen deficiency–induced menopausal-like symptoms in ovariectomized mice
TL;DR: GA has estrogenic and osteogenic activities in OVX mice, MG-63 cells, and MCF-7 cells and was demonstrated to attenuate estrogen deficiency-induced menopausal symptoms.
Journal ArticleDOI
Protective effect of porcine placenta in a menopausal ovariectomized mouse.
Na-Ra Han,Chan-Lee Park,Na-Rae Kim,Hee-Yun Kim,Myoung-schook Yoou,Sun-Young Nam,Phil-Dong Moon,Hyun-Ja Jeong,Hyung-Min Kim +8 more
TL;DR: The results indicate that PPE or Arg would have estrogenic and osteoblastic activity and may be useful as new pharmacological tools for treating menopausal symptoms including osteoporosis.
Journal ArticleDOI
Anticholinesterase activity of Cinnamomum zeylanicum L. leaf extract
Manoj Kumar Dalai,Sahely Bhadra,Sushil K Chaudhary,Joydeb Chanda,Arun Bandyopadhyay,Pulok K. Mukherjee +5 more
TL;DR: In this paper, the anticholinesterase inhibitory activity of methanol extract of Cinnamomum zeylanicum leaves and cinnamon oil was evaluated by 96-well microtiter plate assay and thin layer chromatography bioassay detection methods.
Journal ArticleDOI
Estrogen-like osteoprotective effects of glycine in in vitro and in vivo models of menopause
TL;DR: Glycine has an estrogen-like osteoprotective effect in menopause models and it is suggested that glycine may be useful for the treatment ofMenopause.
Journal ArticleDOI
Cysteine Prevents Menopausal Syndromes in Ovariectomized Mouse.
TL;DR: It is demonstrated that Cys has estrogenic and osteogenic activities in OVX mice, MG-63 cells, and MCF-7 cells, suggesting the potential use of Cys as a new agent for postmenopausal women.
References
More filters
Journal ArticleDOI
AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet
TL;DR: Two new diets may prove to be a better choice than AIN-76A for long-term as well as short-term studies with laboratory rodents because of a better balance of essential nutrients.
Journal ArticleDOI
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
TL;DR: Examination of the 2.8 angstrom crystal structure of the complex between the hormone and the extracellular domain of its receptor (hGHbp) showed that the complex consists of one molecule of growth hormone per two molecules of receptor.
Journal ArticleDOI
The Somatomedin Hypothesis: 2001
TL;DR: In the liverspecific igf-1 gene-deleted mouse model, postnatal growth and development are normal despite the marked reduction in circulating IGF-I and IGF-binding protein levels; free IGF- I levels are normal.
Journal ArticleDOI
How corticosteroids control inflammation: Quintiles Prize Lecture 2005.
TL;DR: In patients with COPD and severe asthma and in asthmatic patients who smoke HDAC2 is markedly reduced in activity and expression as a result of oxidative/nitrative stress so that inflammation becomes resistant to the anti‐inflammatory actions of corticosteroids, and theophylline, by activating HDAC, may reverse this cortiosteroid resistance.
Journal ArticleDOI
The growth hormone receptor: mechanism of activation and clinical implications
TL;DR: A model in which the growth hormone receptor exists as a constitutive dimer is discussed in the light of salient information from closely related class 1 cytokine receptors, such as the erythropoietin, prolactin and thrombopOietin receptors.