Journal ArticleDOI
Effect of serotoninergic drugs on stress-induced hyperthermia (SIH) in mice.
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TLDR
Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione, and TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/ kg did not modify the pattern ofSIH at all.Abstract:
8-OH-DPAT (2.5–10 mg/kg) and buspirone (10 mg/kg) but not 5,7DHT (200 Μg/mouse), pCPA (75 and 150 mg/kg, three times), ritanserin (0.1 and 0.2 mg/kg), LY 53857 (1.5 and 3 mg/kg), GR 38032 F (0.1–100 Μg/kg), TFMPP (5 and 20 mg/kg) and mCPP (2.5 and 5 mg/kg) antagonized the rise in body temperature that occurs to the last mice removed from their group housing, which was termed as stress-induced hyperthermia (SIH). Ro 15-1788, at a dose which blocked the effect of diazepam on SIH, did not reverse the anxiolytic effect of buspirione. Instead, when cerebral 5-HT content was reduced to 50% by 5,7-DHT-induced lesion, the effect of buspirone on SIH was decreased. TFMPP 5 mg/kg did not shorten significantly the onset of SIH as could have been expected by an anxiogenic drug, while the dose of 20 mg/kg did not modify the pattern of SIH at all. The lower dose of TFMPP evoked a hyperthermic and the higher a hypothermic response.read more
Citations
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Journal ArticleDOI
5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: More than 30 years of research
TL;DR: Observations lead to the conclusion that different 5-HT mechanisms, mediated by different receptor subtypes, are involved in the genesis of anxiety.
Journal ArticleDOI
The dorsomedial hypothalamus: a new player in thermoregulation
TL;DR: Neurons concentrated in the dorsal region of the DMH project directly to the rRP, a location corresponding to that of neurons trans-synaptically labeled from IBAT, and these neurons control nonshivering thermogenesis in rats, and their activation signals its recruitment in diverse experimental paradigms.
Journal ArticleDOI
The stress-induced hyperthermia paradigm as a physiological animal model for anxiety: a review of pharmacological and genetic studies in the mouse.
TL;DR: The function, brain mechanisms and pharmacology of stress-induced hyperthermia (SIH) in a broad context, and some of the limitations of the SIH procedure for use of drugs like nicotine, which contain particular characteristics such as short in vivo half-life, and/or disturbance of thermoregulation are presented.
Journal ArticleDOI
Mechanisms and mediators of psychological stress-induced rise in core temperature.
TL;DR: Most findings indicate that the psychological stress–induced rise in core temperature (PSRCT) in animals is a fever, a rise in the thermoregulatory set point.
Journal ArticleDOI
Stress-induced hyperthermia and anxiety: pharmacological validation.
Berend Olivier,Berend Olivier,Theo J.J. Zethof,Tommy Pattij,Meg van Boogaert,Ruud van Oorschot,Ruud van Oorschot,Christina Leahy,Ronald S. Oosting,Arjan Bouwknecht,Arjan Bouwknecht,Jan G. Veening,Jan van der Gugten,Lucianne Groenink +13 more
TL;DR: The stress-induced hyperthermia test in singly housed male and female mice appears a useful and extremely simple test to measure effects of drugs on certain aspects of anxiety or to help to determine phenotypic differences in mutant mice.
References
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Journal ArticleDOI
Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
Thomas J. Haley,W. G. McCORMICK +1 more
TL;DR: After intracerebral injection, drugs of diverse structure produced certain generalized effects: changes in positioning of the tail, stupor, hyperexcitability and tachypnoea, and (+)-methylamphetamine produced only piloerection and exaggerated activity in response to sound and touch.
Journal ArticleDOI
Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.
TL;DR: In rat brain cortex slices preincubated with [3H]5-HT, the evidence indicates that the presynaptic 5- HT autoreceptor belongs to the 5-HT1B receptor subtype.
Journal ArticleDOI
Serotonin function in anxiety. II. Effects of the serotonin agonist MCPP in panic disorder patients and healthy subjects.
TL;DR: In this paper, the role of serotonin function in the development of panic anxiety was assessed in healthy subjects and agoraphobic and panic disorder patients with m-chlorophenylpiperazine (MCPP).
Journal ArticleDOI
5-HT1A receptor-related anxiolytics
Jo¨rg Traber,Thomas Glaser +1 more
TL;DR: The novel anti-anxiety agents buspirone, gepirone and ipsapirone which directly affect the serotonergic system by interacting with the 5- HT 1A subtype of the high affinity 5-HT 1 receptor.
Journal ArticleDOI
The comparative efficacy of buspirone and diazepam in the treatment of anxiety.
TL;DR: A battery of tests indicated that buspirone, a new agent not chemically related to any currently marketed drugs, was as effective an antianxiety agent as diazepam and produced no more and perhaps fewer side effects.