Journal ArticleDOI
Effect of some arylguanidino- and arylaminopyrimidines on the growth of certain microorganisms
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TLDR
2,4-Bis(arylamino)-6-hydroxypyrimidines have been found to be the most active of the series and their inhibitory activity seems to be partially due to their interference with the pyrimidine metabolism of the microorganisms.About:
This article is published in Archives of Biochemistry and Biophysics.The article was published on 1961-02-01. It has received 8 citations till now.read more
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Book ChapterDOI
Some pyrimidines of biological and medicinal interest. 3.
TL;DR: Pyrimidine derivatives have been found to possess fungicidal, antibacterial, antimitotic, antithyroid and surface-anaesthesia activities, with the exception of pyrimidine antibiotics.
Journal ArticleDOI
Structural Modifications of DAPY Analogues with Potent Anti‐HIV‐1 Activity
Xiao-Qing Feng,Yong-Hong Liang,Zhaosen Zeng,Fen-Er Chen,Jan Balzarini,Christophe Pannecouque,Erik De Clercq +6 more
TL;DR: A novel series of diarylpyrimidine analogues (DAPYs) featuring a naphthyl moiety at the C4 position were designed, with all compounds exhibiting strong activity against wild‐type HIV‐1.
Book ChapterDOI
3 Some Pyrimidines of Biological and Medicinal Interest—Part III
C.C. Cheng,Barbara Roth +1 more
TL;DR: Pyrimidines containing two ethylenimine functions have also been found to possess anticancer activity, and 2, 4-Bis (aziridinyl)-6-chloropyrimidine (CV, ethymidine, etimidin) significantly inhibits growth of many transplantable mouse and rat tumours.
Journal ArticleDOI
Effect of a number of n-pyrimidyl amino acids and of some of their 5-arylazo derivatives on the growth of certain microorganisms.
P. Roy-Burman,D. Sen +1 more
TL;DR: Investigation of the mechanism of the inhibitory action of the new N-pyrimidyl compounds in S. faecalis revealed that they acted primarily as folic acid antagonists in a manner consistent with an assumption that they interfere with the enzymatic conversion of folic Acid to 5 N-forrnyl tetrahydrofolic acid.
Journal ArticleDOI
Synthesis of some N-pyrimidyl amino acids: Part II
P. Roy-Burman,D. Sen,B. C. Guha +2 more
References
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Journal ArticleDOI
Arylaminopyrimidines as growth-inhibitors of Streptococcus faecalis and Lactobacillus arabinosus.
TL;DR: It has been found that 2 : 4-diamino-6-alkylpyrimidines which have bulky substituents (for example, phenyl) at C5 are strong folic acid antagonists, some of which have marked anti-malarial and antileukæmic properties.
Journal ArticleDOI
Inhibitory effects of some 2-arylguanidino-4-amino-6-oxy-pyrimidines on the growth of streptococcus faecalis, lactobacillus arabinosus and escherichia coli
TL;DR: Diese D e u t u n g , i m Gegensa tz zu ande ren m6gl ichen, abe t wenig plausiblen, wird wei te rh in gest f i tz d u t c h die Ergebn i s se y o n K r e u z u ng s R e a k t i v i e r b a r sind.