Effect of some metal ions on the activation of prothrombin
01 Jan 1961-Naturwissenschaften (Springer Science and Business Media LLC)-Vol. 48, Iss: 15, pp 526-526
About: This article is published in Naturwissenschaften.The article was published on 1961-01-01. It has received None citations till now. The article focuses on the topics: Metal ions in aqueous solution.
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TL;DR: Thrombin formation has been shown to be inhibited by oxidized glutathione and other sulfhydryl-oxidizing agents and this effect is observed with purified bovine prothrombin and with pro thirdrombin as pre...
Abstract: Thrombin formation has been shown to be inhibited by oxidized glutathione and other sulfhydryl-oxidizing agents. This effect is observed with purified bovine prothrombin and with prothrombin as pre...
6 citations
TL;DR: In preliminary experiments it was observed that BAL was more active as an anticoagulant than cysteine, which made desirable a detailed study of the influence of BAL on the components of the clotting system.
Abstract: SINCE the announcement by Peters, Stocken and Thompson1 of BAL as an antidote for lewisite, the compound finds increasing application in the treatment of poisoning due to arsenicals2, mercury salts3,4 and organic mercurials5 in humans and animals. Substances containing —SH groups are known to influence blood coagulation, for example, thiosulphate6, cysteine7,8 and glutathione9. In preliminary experiments it was observed that BAL was more active as an anticoagulant than cysteine. This made desirable a detailed study of the influence of BAL on the components of the clotting system.
5 citations
3 citations
TL;DR: Manganous ion, 0.0001 M, hastened activation of crude prothrombokinase in a 3-stage analysis of blood coagulation but did not prevent the subsequent steep decline of thrombakinase activity.
Abstract: SummaryManganous ion, 0.0001 M, hastened activation of crude prothrombokinase in a 3-stage analysis of blood coagulation. It did not prevent the subsequent steep decline of thrombokinase activity. Rapid quenching of thrombokinase activity might help in the physiologic control of blood clotting.
2 citations