Effect of trihalomethane exposure on fetal development
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TLDR
Increased pregnancy average and second trimester TTHM exposure were associated with small for gestational age and reductions in birth weight after adjusting for potential confounding variables, and maternal exposure to THMs may be associated with fetal growth retardation.Abstract:
average (odds ratio (OR) 1.14; 95% CI 1.02 to 1.26) and second trimester (OR 1.13, 95% CI 1.03 to 1.24) TTHM levels greater than 80 µg/l. There was no evidence of an association between preterm delivery and increased TTHM levels, but there were slight increases in gestational duration associated with TTHM concentrations. Conclusions: Maternal exposure to THMs may be associated with fetal growth retardation. Our find- ings are consistent with most previous work, although we generally found smaller effects of TTHMs on low birth weight and intrauterine growth retardation.read more
Citations
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Journal ArticleDOI
The effect of disinfection by-products and mutagenic activity on birth weight and gestational duration.
TL;DR: Evidence of an exposure-response effect of trihalomethanes on risk of SGA is found and a relationship between fetal development indices and mutagenic activity independent of exposure to trihalometrichanes, haloacetic acids, and MX is suggested.
Journal ArticleDOI
Overview of Disinfection By-products and Associated Health Effects.
Cristina M. Villanueva,Sylvaine Cordier,Laia Font-Ribera,Lucas A. Salas,Lucas A. Salas,Patrick Levallois +5 more
TL;DR: Future research should develop methods to evaluate the effects of the DBP mixture and the interaction with personal characteristics, clarify the association between swimming pools and respiratory health, evaluate the occurrence of DBPs in low- and middle-income countries, and evaluate outcomes suggested by animal studies that have not been considered in epidemiological investigations.
Journal ArticleDOI
Exposure to disinfection by-products, fetal growth, and prematurity: a systematic review and meta-analysis.
James Grellier,James E. Bennett,Evridiki Patelarou,Rachel B. Smith,Mireille B. Toledano,Lesley Rushton,David J. Briggs,Mark J. Nieuwenhuijsen +7 more
TL;DR: There was little or no evidence for associations between total trihalomethane concentration and adverse birth outcomes relating to fetal growth and prematurity, with the possible exception of SGA.
Journal ArticleDOI
Chlorination disinfection by-products in municipal drinking water – A review
Mohd. Aamir Mazhar,Nadeem A. Khan,Sirajuddin Ahmed,Afzal Husain Khan,Azhar Hussain,Rahisuddin,Fazlollah Changani,Mahmood Yousefi,Shahin Ahmadi,Viola Vambol +9 more
TL;DR: In this paper, the authors have discussed about the formation of disinfection by-products in treated municipal water during chlorination and how these DBPs were discovered and compared the present status of their guidelines value or regulations in India with other regulating bodies and what are the category of cancer groups under which the different DBPs are categorized by WHO.
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Occurrence and Comparative Toxicity of Haloacetaldehyde Disinfection Byproducts in Drinking Water.
Clara H. Jeong,Cristina Postigo,Susan D. Richardson,Jane Ellen Simmons,Susana Y. Kimura,Benito J. Mariñas,Damià Barceló,Damià Barceló,Pei Liang,Elizabeth D. Wagner,Michael J. Plewa +10 more
TL;DR: This study provided the first systematic, quantitative comparison of HAL toxicity in Chinese hamster ovary cells, and found the HALs were highly cytotoxic compared to other DBP chemical classes.
References
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Journal Article
Determinants of low birth weight: Methodological assessment and meta-analysis
TL;DR: There is a need for future research on the effect of maternal work, prenatal care, and certain vitamin and mineral deficiencies on intrauterine growth, and theeffect of genital tract infection, prenatal Care, maternal employment, stress and anxiety on prematurity.
Journal ArticleDOI
Chlorination disinfection byproducts in water and their association with adverse reproductive outcomes: a review
TL;DR: To identify the specific components that may be of aetiological concern and hence to fit the most appropriate exposure model with which to investigate human exposure to chlorinated DBPs, further detailed toxicological assessments of the mixture of byproducts commonly found in drinking water are also needed.
Journal ArticleDOI
Chlorination, chlorination by-products, and cancer: a meta-analysis.
TL;DR: The results of this meta-analysis suggest a positive association between consumption of chlorination by-products in drinking water and bladder and rectal cancer in humans.
Journal ArticleDOI
Public Drinking Water Contamination and Birth Outcomes
Frank J. Bove,Mark C. Fulcomer,Judith B. Klotz,Jorge Esmart,Ellen M. Dufficy,Jonathan E. Savrin +5 more
TL;DR: The effects of public drinking water contamination on birth outcomes were evaluated in an area of northern New Jersey and it cannot resolve whether the drinking water contaminants caused the adverse birth outcomes; therefore, these findings should be followed up utilizing available drinkingWater contamination databases.