Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data
Louise A. Beveridge,Allan D. Struthers,Faisel Khan,Rolf Jorde,Robert Scragg,Helen M. Macdonald,Jessica A. Alvarez,Rebecca S. Boxer,Andrea Dalbeni,Adam D. Gepner,Nicole M. Isbel,Thomas Larsen,Jitender Nagpal,William Petchey,Hans Stricker,Franziska Strobel,Vin Tangpricha,Laura Toxqui,M. Pilar Vaquero,Louise Wamberg,Armin Zittermann,Miles D. Witham +21 more
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TLDR
Vitamin D supplementation is ineffective as an agent for lowering BP and thus should not be used as an antihypertensive agent.Abstract:
MAIN OUTCOMES AND MEASURES Difference in SBP and DBP measured in an office setting. RESULTS We included 46 trials (4541 participants) in the trial-level meta-analysis. Individual patient data were obtained for 27 trials (3092 participants). At the trial level, no effect of vitamin D supplementation was seen on SBP (effect size, 0.0 [95% CI, −0.8 to 0.8] mm Hg; P =. 97;I 2 = 21%) or DBP (effect size, −0.1 [95% CI, −0.6 to 0.5] mm Hg; P = .84; I 2 = 20%). Similar results were found analyzing individual patient data for SBP (effect size, −0.5 [95% CI, −1.3 to 0.4] mm Hg; P =. 27;I 2 = 0%) and DBP (effect size, 0.2 [95% CI, −0.3 to 0.7] mm Hg; P = .38; I 2 = 0%). Subgroup analysis did not reveal any baseline factor predictive of a betterread more
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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects.
TL;DR: The structure of the liganded VDR/RXR complex was recently characterized using cryoelectron microscopy, X-ray scattering, and hydrogen deuterium exchange, which will result in a more complete understanding of VDR coactivator interactions, thus facilitating cell and gene specific clinical applications.
Journal ArticleDOI
Skeletal and Extraskeletal Actions of Vitamin D: Current Evidence and Outstanding Questions.
Roger Bouillon,Claudio Marcocci,Geert Carmeliet,Daniel D. Bikle,John H. White,Bess Dawson-Hughes,Paul Lips,Craig F Munns,Craig F Munns,Marise Lazaretti-Castro,Andrea Giustina,John P. Bilezikian +11 more
TL;DR: There is a need for continued ongoing and future basic and clinical studies to better define whether vitamin D status can be optimized to improve many aspects of human health, and what is plausible regarding the health effects of vitamin D.
Journal ArticleDOI
Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study : A Randomized Clinical Trial
Robert Scragg,Alistair W. Stewart,Debbie Waayer,Carlene M.M. Lawes,Les Toop,John D. Sluyter,Judy Murphy,Kay-Tee Khaw,Carlos A. Camargo +8 more
TL;DR: The Vitamin D Assessment Study as mentioned in this paper was a randomized, double-blind, placebo-controlled trial that recruited participants mostly from family practices in Auckland, New Zealand, from April 5, 2011, through November 6, 2012, with follow-up until July 2015.
Journal ArticleDOI
Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials
Philippe Autier,Patrick Mullie,Alina Macacu,Miruna Dragomir,M. Boniol,Kim Coppens,Cécile Pizot,Mathieu Boniol +7 more
TL;DR: There remains little evidence to suggest that vitamin D supplementation has an effect on most conditions, including chronic inflammation, despite use of increased doses of vitamin D, strengthening the hypothesis that low vitamin D status is a consequence of ill health, rather than its cause.
Journal ArticleDOI
Vitamin D and cardiovascular disease prevention
Stefan Pilz,Nicolas Verheyen,Martin R. Grübler,Martin R. Grübler,Andreas Tomaschitz,Winfried März +5 more
TL;DR: Current available evidence does not support cardiovascular benefits or harms of vitamin D supplementation with the commonly used doses, and whether vitamin D has cardiovascular effects in individuals with overt vitamin D deficiency remains to be evaluated.
References
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TL;DR: The discrepancy between observational and intervention studies suggests that low 25(OH)D is a marker of ill health, and restoration of vitamin D deficits due to ageing and lifestyle changes induced by ill health could explain why low-dose supplementation leads to slight gains in survival.
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TL;DR: The nutritional guidelines for vitamin D(3) intake should be reevaluated, taking into account the contributions to good health that all 36 VDR target organs can provide.