Effectiveness and cost-benefit of influenza vaccination of healthy working adults: a randomized controlled trial
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Cites background from "Effectiveness and cost-benefit of i..."
...However, even during years when vaccine strains were not antigenically well matched to circulating strains (the result of antigenic drift), substantial protection has been observed against severe outcomes, presumably because of vaccine-induced cross-reacting antibodies (121,125,222,283)....
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...effectiveness sometimes are observed compared with seasons when vaccine and circulating strains are well-matched,(107,121,125,173,222)....
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References
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"Effectiveness and cost-benefit of i..." refers background in this paper
...Clinical respiratory illness was defined in 2 ways: (1) ILI was defined as feverishness or a measured temperature of at least 37....
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...Studies have repeatedly demonstrated that influenza vaccination of persons aged 65 years or older is also economically beneficial.(1-4,35) It is less certain whether vaccinating healthy working adults younger than 65 years against influenza would result in societal cost savings....
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...THE COST-EFFECTIVENESS OF INactivated influenza vaccination in reducing influenza illness, hospitalization, and death is well established in persons aged 65 years or older, a group that is at increased risk of severe influenza-related complications.(1-5) However, the benefits of annual influenza vaccination of healthy adults younger than 65 years are less clear....
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850 citations
"Effectiveness and cost-benefit of i..." refers background in this paper
...Studies have repeatedly demonstrated that influenza vaccination of persons aged 65 years or older is also economically beneficial.(1-4,35) It is less certain whether vaccinating healthy working adults younger than 65 years against influenza would result in societal cost savings....
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...THE COST-EFFECTIVENESS OF INactivated influenza vaccination in reducing influenza illness, hospitalization, and death is well established in persons aged 65 years or older, a group that is at increased risk of severe influenza-related complications.(1-5) However, the benefits of annual influenza vaccination of healthy adults younger than 65 years are less clear....
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...7°C ($100°F) plus cough or sore throat (CDC ILI surveillance definition)(29); and (2) upper respiratory illness (URI) was defined as sore throat plus cough, feverishness, or a measured temperature of at least 37....
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720 citations
Additional excerpts
...In our study, as in most studies, only a minority of the respiratory illnesses among adults were due to influenza.(25,37-39) Third, in approximately 1 of every 10 years, there is a poor antigenic match between vaccine strains and the predominant circulating influenza viruses (Nancy J....
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