Effects and mechanisms of silibinin on human hepatoma cell lines.
Citations
13 citations
Additional excerpts
...Accumulating research evidence caspase-9 [8]....
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13 citations
Cites background from "Effects and mechanisms of silibinin..."
...One group reported that silibinin hampers angiogenesis via down-regulation of MMP-2 in a couple of hepatocellular carcinoma cell lines [54]....
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9 citations
9 citations
References
4,927 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... PTEN is a negative regulator of PI3K-Akt signaling [ 29 ]...
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2,869 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... Recent studies have noted a significant rise in the incidence of HCC in the United States in the past 2 decades [ 2 ]...
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...Hepatocellular carcinoma (HCC) is one of the most common malignancies related to a high mortality globally [1, 2 ]...
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2,846 citations
"Effects and mechanisms of silibinin..." refers background in this paper
...Histone acetylation alters chromatin conformation by m a k i n g p r o m o t e r r e g i o n s m o r e a c c e s s i b l e t o transcription factors and permissive to transcriptional activation [ 34 ]...
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...Histone acetylation modifies nucleosome structure that leads to DNA relaxation, reduces the affinity of histone complexes with DNA, and enhances the access of transcriptional factor to DNA [ 34 ]...
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.... Studies have reported that histone acetylation is involved in cell proliferation, differentiation, and cell cycle regulation [ 34 ]...
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2,777 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... PTEN is a tumor suppressor gene and the deletion or inactivation of this gene has been described in a variety of cancer cell lines [ 30 ,33,53]...
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...and one of the most frequently inactivated genes in malignancies [ 30 , 31]...
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1,441 citations
"Effects and mechanisms of silibinin..." refers background or methods in this paper
...Both PCNA and Ki-67 are biomarkers for cell proliferation [ 40 ]...
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...Ki-67 is a commonly used biomarker for cell proliferation [ 40 ]...
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