Effects and mechanisms of silibinin on human hepatoma cell lines.
Citations
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Cites background from "Effects and mechanisms of silibinin..."
...[31]....
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...Silibinin also promotes apoptosis of human hepatoma HuH7 cells by down-regulating survivin and up-regulating activated caspase-3 and -9 [31]....
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...In other studies, silibinin significantly upregulated p21/CDK4 and p27/CDK4 complexes and down-regulated Rb-phosphorylation and E2F1/DP1 complex thereby inhibiting human hepatoma HuH7 cell growth [31]....
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Cites background from "Effects and mechanisms of silibinin..."
...proved that silybin significantly reduces HuH7, HepG2, Hep3B, and PLC/PRF/5 human hepatoma cells growth by increasing cyclin-dependent kinase inhibitor p21 and p27/cyclin-dependent kinase (CDK) 4 complexes, by reducing retinoblastoma protein (Rb)-phosphorylation and transcription factor E2F1/transcription factor dimerization Partner (DP) 1 complex, as well as by promoting induction of codifying genes for caspase 3–9 and reducing the levels of survivin, whose sovraexpression is associated with a reduction of cell death [140,141]....
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References
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"Effects and mechanisms of silibinin..." refers methods in this paper
...The release of phosphate from the substrate was measured in a colorimetric assay using the Biomol Green Reagent (Plymouth Meeting, PA) [ 39 ]...
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150 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... It is well known that milk thistle is safe and well-tolerated, and it protects the liver from drug or alcohol-related injury [7, 8 ]...
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...It is well known that milk thistle is safe and well tolerated, and it protects the liver from drug or alcohol-related injury [7, 8 ]...
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150 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... It was reported that silibinin affects Akt expression in prostate cancer cells [ 16 ]...
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...skin [ 15-17 ] , bladder...
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...Effects of silibinin on PTEN/PI3K/Akt pathway It has been reported that the PTEN/PI3K/Akt pathway is involved in cancer growth [ 16 ,46]...
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148 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... PTEN is a tumor suppressor gene and the deletion or inactivation of this gene has been described in a variety of cancer cell lines [30,33, 53 ]...
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