Effects and mechanisms of silibinin on human hepatoma cell lines.
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Cites background from "Effects and mechanisms of silibinin..."
...[31]....
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...Silibinin also promotes apoptosis of human hepatoma HuH7 cells by down-regulating survivin and up-regulating activated caspase-3 and -9 [31]....
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...In other studies, silibinin significantly upregulated p21/CDK4 and p27/CDK4 complexes and down-regulated Rb-phosphorylation and E2F1/DP1 complex thereby inhibiting human hepatoma HuH7 cell growth [31]....
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...proved that silybin significantly reduces HuH7, HepG2, Hep3B, and PLC/PRF/5 human hepatoma cells growth by increasing cyclin-dependent kinase inhibitor p21 and p27/cyclin-dependent kinase (CDK) 4 complexes, by reducing retinoblastoma protein (Rb)-phosphorylation and transcription factor E2F1/transcription factor dimerization Partner (DP) 1 complex, as well as by promoting induction of codifying genes for caspase 3–9 and reducing the levels of survivin, whose sovraexpression is associated with a reduction of cell death [140,141]....
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References
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"Effects and mechanisms of silibinin..." refers background or result in this paper
...Silibinin at IC25 and IC50 doses for HuH7 cells also resulted in reduced growth of HepG2, Hep3B, and PLC/PRF/5 cells, confirming the previous reports [21, 22 ]...
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...Varghese, et al reported that silibinin increases levels of p27 in human hepatoma cells [ 22 ]...
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...effects [21, 22 ] provided us with a rationale to further define the related effects and mechanisms of HCC chemoprevention....
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...As shown in Figure 1B, silibinin also significantly inhibited the growth of HepG2, Hep3B, and PLC/PRF/5 human HCC cell lines, indicating a wide spectrum of silibinin's inhibitory effects on human HCC cell growth, as previously reported [21, 22 ]...
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...Varghese et al reported silibinin's anti-HCC effects [21, 22 ]...
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129 citations
"Effects and mechanisms of silibinin..." refers background in this paper
.... Studies indicated that silibinin induces apoptosis in several malignant cell lines [13,14, 18 ]...
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..., bladder [ 18 ,19] and lung cancers...
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123 citations
"Effects and mechanisms of silibinin..." refers background or methods in this paper
...protein expression. MMP-2 and MMP-9 have been used as markers for angiogenesis and malignant invasion [ 45 ]...
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...and MMP-2 and MMP-9, which are markers associated with angiogenesis as well as metastatic invasion [ 45 ]...
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