Effects and mechanisms of silibinin on human hepatoma cell lines.
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Cites background from "Effects and mechanisms of silibinin..."
...[31]....
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...Silibinin also promotes apoptosis of human hepatoma HuH7 cells by down-regulating survivin and up-regulating activated caspase-3 and -9 [31]....
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...In other studies, silibinin significantly upregulated p21/CDK4 and p27/CDK4 complexes and down-regulated Rb-phosphorylation and E2F1/DP1 complex thereby inhibiting human hepatoma HuH7 cell growth [31]....
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Cites background from "Effects and mechanisms of silibinin..."
...proved that silybin significantly reduces HuH7, HepG2, Hep3B, and PLC/PRF/5 human hepatoma cells growth by increasing cyclin-dependent kinase inhibitor p21 and p27/cyclin-dependent kinase (CDK) 4 complexes, by reducing retinoblastoma protein (Rb)-phosphorylation and transcription factor E2F1/transcription factor dimerization Partner (DP) 1 complex, as well as by promoting induction of codifying genes for caspase 3–9 and reducing the levels of survivin, whose sovraexpression is associated with a reduction of cell death [140,141]....
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References
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"Effects and mechanisms of silibinin..." refers background or result in this paper
...Possible effects of silibinin on angiogenesis In previous studies, silibinin has been reported to inhibit angiogenesis in non-HCC cancer cell lines [ 13 ]...
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.... Previous studies on other cancer cell lines showed a significant inhibitory effect of silibinin on the cell cycle progression [ 11-13 ]...
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.... Studies indicated that silibinin induces apoptosis in several malignant cell lines [ 13 ,14,18]...
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..., colon [ 13 ,14] ,...
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.... As noted in previous studies on other cancer cell lines [ 12-14 ]...
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82 citations
"Effects and mechanisms of silibinin..." refers background or result in this paper
.... As noted in previous studies on other cancer cell lines [ 12-14 ]...
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.... Previous studies on other cancer cell lines showed a significant inhibitory effect of silibinin on the cell cycle progression [ 11-13 ]...
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...Studies demonstrated silibinin's inhibitory effects on multiple cancer cell lines, including prostate [ 9-12 ]...
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79 citations
"Effects and mechanisms of silibinin..." refers methods or result in this paper
...Using MTT assay [37, 38 ] , we demonstrated that silibinin treatment resulted in a potent inhibition of four different human HCC cell lines, indicating its broad spectrum of anti-HCC effects....
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.... Briefly, the effects of silibinin on HCC cell growth were then determined after 24 h of incubation by optical density absorbance at 490 nm according to the manufacturer's instruction [37, 38 ]...
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...All the cells were cultured, as previously reported [37, 38 ]...
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...Apoptosis was determined in duplicate using an EIA kit for cell death detection, as previously reported [37, 38 ]...
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...Human HCC cell lines, HuH7, HepG2, PLC/PRF/5, and Hep3B cells [37, 38 ]...
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