Journal ArticleDOI
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on lipid profiles in tissue of the Fischer rat.
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A rapid, dose-dependent effect of TCDD, was the elevation of levels of organic-soluble fluorescent pigment in the heart, which was found to match a previously characterized fraction of lipofuscins in fluorescence spectrum and chromatographic properties.About:
This article is published in Chemico-Biological Interactions.The article was published on 1978-12-01. It has received 93 citations till now. The article focuses on the topics: Fatty acid & Triglyceride.read more
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2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
Alan Poland,Joyce C. Knutson +1 more
TL;DR: The toxicity of halogenated aromatic hydrocarbons appears to be due to the sustained expression of a normal cellular regulatory system, of which the author was previously unaware.
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Polychlorinated biphenyls as hormonally active structural analogues.
James D. McKinney,C L Waller +1 more
TL;DR: This work compares qualitative structure-activity relationships for PCBs with the limited information on the related non-coplanar chlorinated diphenyl ethers, providing further insights into the nature of the molecular recognition processes and support for the structural relationship of PCBs to thyroid hormones.
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Free radical biology: xenobiotics, cancer, and aging.
TL;DR: Current thinking on the in vivo sources of radicals is summarized, covering both exogenous sources-xenobiotics, pollutants, carcinogens, etc.-and endogenous sources-superoxide systems and the arachidonic cascade and the effects of antioxidants on carcinogenesis and on the retardation of aging.
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Oxidative stress induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
TL;DR: Oxidative damage may contribute to many of the toxic responses produced by TCDD and its bioisosteres, and may be common to most of the tissue-damaging effects.
Journal ArticleDOI
PGRMC1 (progesterone receptor membrane component 1): a targetable protein with multiple functions in steroid signaling, P450 activation and drug binding.
TL;DR: Together with its biological role in promoting tumor survival, PGRMC1 is an attractive target for therapeutic intervention in cancer and related malignancies.
References
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Journal ArticleDOI
A simple method for the isolation and purification of total lipides from animal tissues.
TL;DR: In this paper, the authors described a simplified version of the method and reported the results of a study of its application to different tissues, including the efficiency of the washing procedure in terms of the removal from tissue lipides of some non-lipide substances of special biochemical interest.
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Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride–methanol
William R. Morrison,L.M. Smith +1 more
TL;DR: The procedure developed is simple, rapid, and generally applicable t o lipids, and the results did not affect the validity of the method.
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The plasma lecithin:cholesterol acyltransferase reaction
TL;DR: Several indications exist that the acyltransferase reaction is the major source of plasma esterified cholesterol in man, and one possibility is that it plays a role in the transport of cholesterol from peripheral tissues to the liver.
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Separation of lipid classes by chromatography on Florisil.
TL;DR: Preliminary experiments indicated that chromatography on Florisil gave good separations of lipid classes of naturally occurring lipids extracted from liver and blood.
Related Papers (5)
2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity
Alan Poland,Joyce C. Knutson +1 more