Effects of 2 low-fat stanol ester–containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects
01 Mar 1999-The American Journal of Clinical Nutrition (American Society for Nutrition)-Vol. 69, Iss: 3, pp 403-410
TL;DR: It is concluded that the low-fat, plant stanol ester-containing margarines are effective cholesterol-lowering products in hypercholesterolemic subjects when used as part of a low-Fat, low-cholesterol diet.
About: This article is published in The American Journal of Clinical Nutrition.The article was published on 1999-03-01 and is currently open access. It has received 240 citations till now. The article focuses on the topics: Stanol ester & Plant stanol ester.
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TL;DR: Los resultados confirman that the administracion of estanoles vegetales en dosis of 2 g/dia durante 1 ano produce una reduccion significativa (ligeramente superior al 10%) of las concentraciones de colesterol unido a lipoproteinas de baja densidad en sujetos con hipercolesterolemia.
Abstract: Resumen Introduccion y objetivos El consumo de estanoles vegetales puede contribuir a un mejor control a largo plazo del colesterol. El objetivo es evaluar la eficacia del aporte de estanoles vegetales, a dosis de 2 g/dia, en la reduccion de las cifras de colesterol unido a lipoproteinas de baja densidad de los pacientes con hipercolesterolemia. Metodos Se realizo un ensayo clinico aleatorizado, a doble ciego y controlado con placebo, en el que se incluyo a 182 sujetos adultos diagnosticados de hipercolesterolemia. Se administro yogur liquido con 2 g de estanoles vegetales a 91 sujetos del grupo intervencion y yogur no suplementado a 91 del grupo control. La variable principal fue la variacion del perfil lipidico a los 12 meses. Resultados En comparacion con el placebo, a los 12 meses se observo una disminucion significativamente superior del colesterol unido a lipoproteinas de baja densidad en el grupo que tomo estanoles: 13,7 (intervalo de confianza del 95%, 3,2-24,1) mg/dl (p = 0,011). En este grupo fue significativamente superior la proporcion de sujetos que redujeron en mas del 10% sus cifras de colesterol unido a lipoproteinas de baja densidad (riesgo relativo = 1,7; intervalo confianza del 95%, 1,1-2,7). En el grupo tratado, el colesterol unido a lipoproteinas de baja densidad descendio, en promedio, un 11,0 ± 23,9%. Conclusiones Los resultados confirman que la administracion de estanoles vegetales en dosis de 2 g/dia durante 1 ano produce una reduccion significativa (ligeramente superior al 10%) de las concentraciones de colesterol unido a lipoproteinas de baja densidad en sujetos con hipercolesterolemia. Registro del ensayo ( www.ClinicalTrials.gov ): Current Controlled Trials NCT01406106.
16 citations
01 Jun 2006
TL;DR: Son yillarda yapilan calismalar, kolesterol dusurucu etkiyi en ust seviyede olusturan miktarin gunluk 2–3 g olmasi gerektigini gostermektedir.
Abstract: engelleyerek, kandaki toplam ve LDL kolesterol seviyelerini dusurucu etkiye sahiptirler. Bu yuzden, fitosteroller yaklasik yarim asirdan beri kolesterol dusurucu ajanlar olarak bilinmektedirler. Fitosteroller bitkisel urunlerde ozellikle bitkisel yaglarda dogal halde bulunurlar. Normal diyetle alinan gunluk fitosterol miktari, tuketim aliskanliklari ve gida cesidine bagli olarak 170 mg’dan 360 mg’a kadar degismektedir. Son yillarda yapilan calismalar, kolesterol dusurucu etkiyi en ust seviyede olusturan miktarin gunluk 2–3 g olmasi gerektigini gostermektedir. Bu seviyedeki fitosterol tuketimi, fitosterollerle zenginlestirilmis gida alimini gerektirmektedir
16 citations
TL;DR: The Panel on Dietetic Products, Nutrition and Allergies concludes that plant stanol esters at a daily intake of 3 g plant stanols lowers LDL-cholesterol by 11.4 % and the minimum duration required to achieve the maximum effect of plant st ethanol esters on LDL-Cholesterol lowering is two to three weeks.
Abstract: Following an application from Raisio Nutrition Ltd, submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of Finland, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to 3 g/day plant stanols as plant stanol esters per day and lowering blood LDL-cholesterol by 12 % and reduced risk of (coronary) heart disease. The applicant has further requested that the minimum duration to obtain the effect be stated to be one to two weeks, and that the claims be authorised for an extended range of foods, including yellow fat spreads, dairy products, cheese, rye bread, oatmeal, fermented soy milk based products (drinkable and spoonable yoghurt-type products), and oat based milk drinks. The applicant provided an unpublished meta-analysis with 18 randomised, controlled human studies on the LDL-lowering efficacy of plant stanol esters at intakes between 2.7 to 3.3 g per day plant stanols. On the basis of the data presented, the Panel concludes that plant stanol esters at a daily intake of 3 g plant stanols (range 2.7 g to 3.3 g) in matrices approved by Regulation (EC) No 376/2010 (yellow fat spreads, dairy products, mayonnaise and salad dressings) lowers LDL-cholesterol by 11.4 % (95% CI: 9.8 – 13.0), that the minimum duration required to achieve the maximum effect of plant stanol esters on LDL-cholesterol lowering is two to three weeks, and that while plant stanol esters added to foods such as margarine-type spreads, mayonnaise, salad dressings, and dairy products such as milk, yoghurts including low-fat yoghurts, and cheese have been shown consistently to lower blood LDL-cholesterol levels, the size of the cholesterol-lowering effect of plant stanols added to other food formats is less well established.
16 citations
TL;DR: The consumption of plant sterol-enriched milk tea decreased cholesterol concentrations although to a lesser extent than was anticipated, and the reason for reduced efficacy is unclear but may be attributable to the novel food format used or the Chinese population studied.
Abstract: The cholesterol-lowering effects of plant sterols in a format suitable for use in China have not previously been investigated. We conducted the study to quantify in adult Chinese the effects on blood lipid concentrations of a plant sterol-enriched milk tea powder. The study was a double-blind, randomised trial in which 309 participants were randomised to receive daily 2.3 or 1.5 g plant sterol supplementation or placebo for 5 weeks. The milk tea was consumed with the two fattiest meals of the day with half the assigned daily dose taken on each occasion. Fasting venous blood samples were collected before commencement and upon completion of randomised treatment. The mean age of study participants was 44 years, 62% were female and 62% had a history of hypercholesterolaemia. Baseline mean total cholesterol was 5.5 mmol/l and LDL-cholesterol was 3.2 mmol/l. Compared with placebo, the 2.3 g/d plant sterol dose reduced total cholesterol by 0.25 (95% CI 0.07, 0.43) mmol/l (P = 0.01) and the 1.5 g/d dose by 0.23 (95% CI 0.06, 0.41) mmol/l (P = 0.01). For LDL-cholesterol the corresponding reductions were 0.17 (95% CI 0.00, 0.35) mmol/l (P = 0.06) and 0.15 (95% CI -0.02, 0.32) mmol/l (P = 0.08). For neither outcome was there evidence of differences between the effects of the two doses (both P values >0.4). In conclusion, the consumption of plant sterol-enriched milk tea decreased cholesterol concentrations although to a lesser extent than was anticipated. The reason for reduced efficacy is unclear but may be attributable to the novel food format used or the Chinese population studied.
16 citations
TL;DR: The NPY genotype neither affects the magnitude of postprandial lipemia induced by a fat tolerance test nor the response of serum total lipids or lipids in different lipop protein classes to the reduced fat diet, however, this preliminary study suggests that there might be compositional differences in the lipoprotein particles between the genotype groups that affect postpr andial lipid metabolism.
Abstract: Objective: The aim of the study was to examine the impact of the leucine7 to proline7 (Leu7Pro) polymorphism of the NPY gene on postprandial (PP) lipemia, post-heparin plasma lipoprotein lipase (LPL) and hepatic lipase (HL) activities, and the response of serum lipids to a reduced fat diet. Design and subjects: Seven middle-aged obese subjects with Leu7Pro genotype were matched with seven subjects with Leu7Leu genotype for gender, age, apolipoprotein E phenotype and BMI. These 14 subjects participated in the oral 8 h fat tolerance test. Sixty-eight slightly obese middle-aged subjects (10 with the Leu7Pro genotype) had participated in intervention studies and consumed a reduced fat diet for 8 weeks. Results: There were no statistically significant differences in PP areas under the curve of plasma total triglycerides (TG), chylomicron TG, VLDL-TG or insulin between the genotype groups. The TG-to-cholesterol (C) ratio in VLDL was significantly lower in the subjects with Leu7Pro genotype compared to those with the Leu7Leu genotype at time points 30 min and 1 h in the fat tolerance test. Heparin-induced activities of LPL or HL or the response of serum total or LDL-C to the reduced fat diet did not differ between the groups. Conclusions: The NPY genotype neither affects the magnitude of postprandial lipemia induced by a fat tolerance test nor the response of serum total lipids or lipids in different lipoprotein classes to the reduced fat diet. However, this preliminary study suggests that there might be compositional differences in the lipoprotein particles between the genotype groups that affect postprandial lipid metabolism. Sponsorship: The Council for Health Sciences of the Academy of Finland, Kuopio University Hospital and the National Technology Agency, Finland.
15 citations
Cites result from "Effects of 2 low-fat stanol ester–c..."
...The results of these two diet intervention studies have been previously presented representing the results of the whole study group (Sarkkinen et al, 1998; Hallikainen & Uusitupa, 1999)....
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References
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TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Abstract: THE SECOND report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II, or ATP II) presents the National Cholesterol Education Program's updated recommendations for cholesterol management. It is similar to the first in general outline, and the fundamental approach to treatment of high blood cholesterol is comparable. This report continues to identify low-density lipoproteins (LDL) as the primary target of cholesterol-lowering therapy. As in the first report, the second report emphasizes the role of the clinical approach in primary prevention of coronary heart disease (CHD). Dietary therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD. However, the second report contains new features that distinguish it from the first. These include the following: Increased emphasis on See also pp 3002 and 3009.
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Abstract: SPSS for Windows: base system user's guide release 6.0 , SPSS for Windows: base system user's guide release 6.0 , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
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TL;DR: In this paper, the authors tested the tolerability and cholesterol-lowering effect of margarine containing sitostanol ester in a population with mild hypercholesterolemia.
Abstract: Background Dietary plant sterols, especially sitostanol, reduce serum cholesterol by inhibiting cholesterol absorption. Soluble sitostanol may be more effective than a less soluble preparation. We tested the tolerability and cholesterol-lowering effect of margarine containing sitostanol ester in a population with mild hypercholesterolemia. Methods We conducted a one-year, randomized, double-blind study in 153 randomly selected subjects with mild hypercholesterolemia. Fifty-one consumed margarine without sitostanol ester (the control group), and 102 consumed margarine containing sitostanol ester (1.8 or 2.6 g of sitostanol per day). Results The margarine containing sitostanol ester was well tolerated. The mean one-year reduction in serum cholesterol was 10.2 percent in the sitostanol group, as compared with an increase of 0.1 percent in the control group. The difference in the change in serum cholesterol concentration between the two groups was -24 mg per deciliter (95 percent confidence interval, -17 to -...
752 citations