Effects of 2 low-fat stanol ester–containing margarines on serum cholesterol concentrations as part of a low-fat diet in hypercholesterolemic subjects
01 Mar 1999-The American Journal of Clinical Nutrition (American Society for Nutrition)-Vol. 69, Iss: 3, pp 403-410
TL;DR: It is concluded that the low-fat, plant stanol ester-containing margarines are effective cholesterol-lowering products in hypercholesterolemic subjects when used as part of a low-Fat, low-cholesterol diet.
About: This article is published in The American Journal of Clinical Nutrition.The article was published on 1999-03-01 and is currently open access. It has received 240 citations till now. The article focuses on the topics: Stanol ester & Plant stanol ester.
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30 Jan 2015
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TL;DR: Results indicate that a daily intake of about 0.45 g phytosterol beneficially affect the levels of total- and LDL-cholesterol even in healthy subjects with a slightly elevated serum cholesterol level, and that it may be helpful in reducing the risk of CHD.
Abstract: Phytosterols are natural dietary components and their lowering effect on serum cholesterol level has been well documented. There have been few reports about the effect of less than 1g/day of phytosterol on serum cholesterol level. We attempted to investigate serum cholesterol lowering effect of phytosterol at 2 relatively low doses. In a randomized, double-blind, 3-group parallel protocol, 67 healthy men with a total cholesterol of 221.5 ± 17.0 (mean ± SD, mg/dL) consumed each about 0.04 g/day, 0.29 g/day and 0.45 g/day of phytosterol (as the major free sterol) for 4 weeks. The level of total cholesterol decreased by 1.0%, 0.5% and 7.9% in the control, the low-and the high-phytosterol group, respectively. As for LDL-cholesterol level, these decreases were 1.8%, 1.0% and 9.5%, respectively. The relative reduction rates of total-and LDL-cholesterol levels in the high-phytosterol group were significantly different from the others, whereas no difference between the control and the low-phytosterol group were observed. No significant difference in the levels of VLDL-cholesterol, HDL-cholesterol or triacylglycerol were found among the groups. Apolipoprotein B and RLP-cholesterol levels were also lower in the higher group. These results indicate that a daily intake of about 0.45 g phytosterol beneficially affect the levels of total- and LDL-cholesterol even in healthy subjects with a slightly elevated serum cholesterol level, and that it may be helpful in reducing the risk of CHD.
6 citations
TL;DR: In this paper, the efecto of distintos fitosteroles sobre the biosintesis de colesterol in celulas humanas and their repercusion sobre la proliferación celular was investigated.
6 citations
TL;DR: A plant sterol-egg yolk lipoprotein complex (PSY) that can be dispersed in water and considered suitable for use in processed foods was developed and the cholesterol-lowering activity was equal to that of free plant sterols and plant sterl esters.
Abstract: Free plant sterols cannot be dissolved in oil or water. Using free plant sterols and egg yolks, we developed a plant sterol-egg yolk lipoprotein complex (PSY) that can be dispersed in water and considered suitable for use in processed foods. The cholesterol-lowering activity of PSY was equal to that of free plant sterols and plant sterol esters. Consumption of a freeze-dried PSY-containing omelet reduced serum and hepatic cholesterol concentrations. The results suggest that PSY has cholesterol-lowering activity equivalent to that of free plant sterols and plant sterol esters. Moreover, the cholesterol-lowering activity of PSY was maintained in processed foods.
6 citations
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TL;DR: Dairy therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD, and the fundamental approach to treatment is comparable.
Abstract: THE SECOND report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II, or ATP II) presents the National Cholesterol Education Program's updated recommendations for cholesterol management. It is similar to the first in general outline, and the fundamental approach to treatment of high blood cholesterol is comparable. This report continues to identify low-density lipoproteins (LDL) as the primary target of cholesterol-lowering therapy. As in the first report, the second report emphasizes the role of the clinical approach in primary prevention of coronary heart disease (CHD). Dietary therapy remains the first line of treatment of high blood cholesterol, and drug therapy is reserved for patients who are considered to be at high risk for CHD. However, the second report contains new features that distinguish it from the first. These include the following: Increased emphasis on See also pp 3002 and 3009.
28,495 citations
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01 Jan 1993
TL;DR: In an ultrasonic alarm detector of the doppler detection type, the improvement comprising a second transmitter transducer disposed remote from the detector and driven from the master oscillator at the detector thereby extending the operating range of the detector to up to twice the range attainable without the second transmitter Transducer.
Abstract: SPSS for Windows: base system user's guide release 6.0 , SPSS for Windows: base system user's guide release 6.0 , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
1,643 citations
1,177 citations
TL;DR: In this paper, the authors tested the tolerability and cholesterol-lowering effect of margarine containing sitostanol ester in a population with mild hypercholesterolemia.
Abstract: Background Dietary plant sterols, especially sitostanol, reduce serum cholesterol by inhibiting cholesterol absorption. Soluble sitostanol may be more effective than a less soluble preparation. We tested the tolerability and cholesterol-lowering effect of margarine containing sitostanol ester in a population with mild hypercholesterolemia. Methods We conducted a one-year, randomized, double-blind study in 153 randomly selected subjects with mild hypercholesterolemia. Fifty-one consumed margarine without sitostanol ester (the control group), and 102 consumed margarine containing sitostanol ester (1.8 or 2.6 g of sitostanol per day). Results The margarine containing sitostanol ester was well tolerated. The mean one-year reduction in serum cholesterol was 10.2 percent in the sitostanol group, as compared with an increase of 0.1 percent in the control group. The difference in the change in serum cholesterol concentration between the two groups was -24 mg per deciliter (95 percent confidence interval, -17 to -...
752 citations