Journal ArticleDOI
Effects of age and exercise on the extent of the myocardial capillary bed
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While aging is associated with a decrease in the concentration of ventricular capillaries, chronic exercise provides some mechanism which enhances the extent of the capillary bed.Abstract:
The age-related response of the ventricular capillary bed to enhanced work loads was investigated in male albino rats. During the 12-week experimental period young, adult and old animals were trained on a motor-driven treadmill. Resting bradycardia was found to occur after 8–12 weeks of training. Demonstration of the ventricular capillary bed was accomplished by injecting Pelikan biological ink retrograde into the ascending aorta of a beating heart. Capillary/muscle fiber ratios were slightly (6.5–9.5% ), but significantly, increased in all trained groups. The number of capillaries/mm2 decreased with age but was higher in trained animals. Thus while aging is associated with a decrease in the concentration of ventricular capillaries, chronic exercise provides some mechanism which enhances the extent of the capillary bed.read more
Citations
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Journal ArticleDOI
Regulation of Coronary Blood Flow During Exercise
Dirk J. Duncker,Robert J. Bache +1 more
TL;DR: The coronary collateral system embodies a dynamic network of interarterial vessels that can undergo both long- and short-term adjustments that can modulate blood flow to the dependent myocardium, and training augments endothelium-dependent vasodilation throughout the coronary microcirculation.
Journal ArticleDOI
Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.
TL;DR: Regression analysis demonstrated that the aging process was characterized by a loss of 38 million and 14 million myocyte nuclei/yr in the left and right ventricular myocardium, respectively, which may represent the structural basis for the reduced compensatory capacity of the aged heart.
Journal ArticleDOI
Angiogenesis in skeletal and cardiac muscle
TL;DR: The role that mechanical factors deriving from blood flow play in the growth of blood vessels was most probably mentioned for the first time by John Hunter in his “Treatise on the Blood Flow, Inflammation and Gunshot Wounds,” published in 1794 and later shown in tadpole tails by Clark.
Journal ArticleDOI
Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.
TL;DR: In conclusion, myocyte cellular hyperplasia tends to regenerate the ventricular mass being lost with age in the adult mammalian rat heart.
Journal ArticleDOI
Cardiovascular Effects and Benefits of Exercise.
TL;DR: There is evidence to suggest that continuously high levels of exercise (e.g., marathon running) could have detrimental effects on cardiovascular health and further studies are needed to identify the mechanisms that impart cardiovascular benefits of exercise in order to develop more effective exercise regimens.
References
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The regeneration of aortic endothelium.
Journal ArticleDOI
A modification of Mallory's connective tissue stain with a discussion of the principles involved
Journal ArticleDOI
Effect of Exercise and Coronary Artery Narrowing on Coronary Collateral Circulation
TL;DR: The data indicate that moderate and severe arterial narrowing results in extensive collateral development proportional to the degree of narrowing, further that exercise leads to even greater anastomoses, and that the addition of exercise promotes an effective collateral circulation.
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