Effects of an Acute Exercise Bout on Serum Hepcidin Levels
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...exhaustive exercise has been shown to increase IL-6 and hepcidin levels [46], which may be one among several factors that cause iron deficiency in athletes following intense periods of training....
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...With few exceptions, the prevalence in the use of supplements is similar for men and women [21], although men athletes tend to consume more protein-based supplements, and women athletes tend to use more iron supplements [22], potentially due to the greater prevalence of iron deficiency in females [23,24]....
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References
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"Effects of an Acute Exercise Bout o..." refers background in this paper
...Then, the protein divalent metal transporter 1 (DMT1) transports the Fe2+ across the enterocyte’s cell membrane into the cell [32]....
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"Effects of an Acute Exercise Bout o..." refers background in this paper
...Consequently, instead of the post-exercise increase, the chronic elevation of IL-6 at baseline may be interpreted as a pro-inflammatory signal that may activate the inflammatory-induced expression of hepcidin observed in vitro and in vivo [46,119]....
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...Finally, since hepcidin and iron storage work in a controlled feedback system [46,47], it is expected that a diet or a supplement rich in iron may produce an upregulation of the post-exercise levels of hepcidin as an attempt to ensure iron homeostasis....
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...Therefore, hepcidin and iron storage work in a control feedback system by which the elevation of iron regulates the synthesis of hepcidin [46]; while a decrease in the concentrations of this mineral (e....
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2,063 citations
"Effects of an Acute Exercise Bout o..." refers background in this paper
...peptide (HAMP) gene and mainly synthesized by hepatocytes, although macrophages, neutrophils, and cancerous cells can express hepcidin as well [40,41]....
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"Effects of an Acute Exercise Bout o..." refers background in this paper
...Nevertheless, although the post-exercise elevation of the circulating fraction of IL-6 may have an anti-inflammatory function, the chronic increase of this cytokine is known to be an inflammatory marker found in different populations [112,113]....
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