Journal ArticleDOI
Effects of bariatric surgery on mortality in Swedish obese subjects.
Lars Sjöström,Kristina Narbro,C. David Sjöström,Kristjan Karason,B Larsson,Hans Wedel,Theodore Lystig,Marianne Sullivan,Claude Bouchard,Björn Carlsson,Calle Bengtsson,Sven Dahlgren,Anders Gummesson,Peter Jacobson,Jan Karlsson,Anna Karin Lindroos,Hans Lönroth,Ingmar Näslund,Torsten Olbers,Kaj Stenlöf,Jarl S Torgerson,Göran Ågren,Lena M. S. Carlsson +22 more
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TLDR
Bariatric surgery for severe obesity is associated with long-term weight loss and decreased overall mortality.Abstract:
Background Obesity is associated with increased mortality. Weight loss improves cardiovascular risk factors, but no prospective interventional studies have reported whether weight loss decreases overall mortality. In fact, many observational studies suggest that weight reduction is associated with increased mortality. Methods The prospective, controlled Swedish Obese Subjects study involved 4047 obese subjects. Of these subjects, 2010 underwent bariatric surgery (surgery group) and 2037 received conventional treatment (matched control group). We report on overall mortality during an average of 10.9 years of follow-up. At the time of the analysis (November 1, 2005), vital status was known for all but three subjects (follow-up rate, 99.9%). Results The average weight change in control subjects was less than ±2% during the period of up to 15 years during which weights were recorded. Maximum weight losses in the surgical subgroups were observed after 1 to 2 years: gastric bypass, 32%; vertical-banded gastropl...read more
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The metabolic syndrome
TL;DR: The pathophysiology seems to be largely attributable to insulin resistance with excessive flux of fatty acids implicated, and a proinflammatory state probably contributes to the metabolic syndrome.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2013 Update A Report From the American Heart Association
Alan S. Go,Dariush Mozaffarian,Véronique L. Roger,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Sheila Franco,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Mark D. Huffman,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,David J. Magid,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Pamela J. Schreiner,Paul D. Sorlie,Joel Stein,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +39 more
TL;DR: Author(s): Go, Alan S; Mozaffarian, Dariush; Roger, Veronique L; Benjamin, Emelia J; Berry, Jarett D; Borden, William B; Bravata, Dawn M; Dai, Shifan; Ford, Earl S; Fox, Caroline S; Franco, Sheila; Fullerton, Heather J; Gillespie, Cathleen; Hailpern, Susan M; Heit, John A; Howard, Virginia J; Huff
Journal ArticleDOI
Heart Disease and Stroke Statistics—2012 Update A Report From the American Heart Association
Véronique L. Roger,Alan S. Go,Donald M. Lloyd-Jones,Emelia J. Benjamin,Jarett D. Berry,William B. Borden,Dawn M. Bravata,Shifan Dai,Earl S. Ford,Caroline S. Fox,Heather J. Fullerton,Cathleen Gillespie,Susan M. Hailpern,John A. Heit,Virginia J. Howard,Brett M. Kissela,Steven J. Kittner,Daniel T. Lackland,Judith H. Lichtman,Lynda D. Lisabeth,Diane M. Makuc,Gregory M. Marcus,Ariane Marelli,David B. Matchar,Claudia S. Moy,Dariush Mozaffarian,Michael E. Mussolino,Graham Nichol,Nina P. Paynter,Elsayed Z. Soliman,Paul D. Sorlie,Nona Sotoodehnia,Tanya N. Turan,Salim S. Virani,Nathan D. Wong,Daniel Woo,Melanie B. Turner +36 more
TL;DR: The American Heart Association's 2020 Impact Goals for Cardiovascular Diseases and Disorders are revealed, with a focus on preventing, treating, and preventing heart disease and stroke.
Journal ArticleDOI
The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases.
Naga Chalasani,Zobair M. Younossi,Joel E. Lavine,Michael Charlton,Kenneth Cusi,Mary E. Rinella,Stephen A. Harrison,Elizabeth M. Brunt,Arun J. Sanyal +8 more
TL;DR: This guidance provides a data-supported approach to the diagnostic, therapeutic, and preventive aspects of NAFLD care.
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Standards of Medical Care in Diabetes—2012
TL;DR: These standards of care are intended to provide clinicians, patients, researchers, payers, and other interested individuals with the components of diabetes care, general treatment goals, and tools to evaluate the quality of care.
References
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Prevalence of Overweight and Obesity in the United States, 1999-2004
Cynthia L. Ogden,Margaret D. Carroll,Lester R. Curtin,Margaret McDowell,Carolyn J. Tabak,Katherine M. Flegal +5 more
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Prevalence of Overweight and Obesity in the United States
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Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery
TL;DR: A prospective, controlled Swedish Obese Subjects Study involved obese subjects who underwent gastric surgery and contemporaneously matched, conventionally treated obese control subjects, which reported follow-up data for subjects who had been enrolled for at least 2 years or 10 years before the analysis.
Journal ArticleDOI
Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
TL;DR: Intervention in obesity, in addition to the well established risk factors, appears to be an advisable goal in the primary prevention of CVD.