Effects of chemotherapy and radiotherapy on spermatogenesis in humans.
Reads0
Chats0
TLDR
Most of the newer biologic targeted therapies seem to have only modest effects, mostly on the endocrine aspects of the male reproductive system; however, their effects when used in combination with cytotoxic agents have not been well studied.About:
This article is published in Fertility and Sterility.The article was published on 2013-11-01 and is currently open access. It has received 278 citations till now. The article focuses on the topics: Stem cell & Azoospermia.read more
Citations
More filters
Journal ArticleDOI
Adolescent and Young Adult Oncology, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology.
Peter F. Coccia,Alberto S. Pappo,Lynda K. Beaupin,Virginia F. Borges,Scott C. Borinstein,Rashmi Chugh,Shira Dinner,Jeanelle Folbrecht,A. Lindsay Frazier,Robert E. Goldsby,Alexandra Gubin,Robert J. Hayashi,Mary S. Huang,Michael P. Link,John A. Livingston,Yousif Matloub,Frederick Millard,Kevin C. Oeffinger,Diane Puccetti,Damon R. Reed,Steven I. Robinson,Abby R. Rosenberg,Tara Sanft,Holly Spraker-Perlman,Margaret von Mehren,Daniel S. Wechsler,Kimberly Whelan,Nicholas D. Yeager,Lisa A. Gurski,Dorothy A. Shead +29 more
TL;DR: This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology focuses on treatment and management considerations for AYA patients with cancer.
Journal ArticleDOI
Sexual dysfunction and infertility as late effects of cancer treatment
Leslie R. Schover,Marleen A. E. van der Kaaij,Eleonora B.L. van Dorst,Carien L. Creutzberg,Eric Huyghe,Cecilie E. Kiserud +5 more
TL;DR: Advances in knowledge about how cancer treatments may damage fertility, as well as newer techniques to preserve fertility, offer hope to patients who have not completed their childbearing at cancer diagnosis and a multidisciplinary approach is suggested.
Journal ArticleDOI
Update on fertility preservation from the Barcelona International Society for Fertility Preservation-ESHRE-ASRM 2015 expert meeting: indications, results and future perspectives.
Francisca Martínez,Claus Yding Andersen,P.N. Barri,Robert E. Brannigan,A. Cobo,Jacques Donnez,Marie Madeleine Dolmans,J.L.H. (Hans) Evers,Anis Feki,Mariëtte Goddijn,Clarisa R. Gracia,Sam Kim,Dror Meirow,Pasquale Patrizio,Antonio Pellicer,Helen M. Picton,Mitchel Rosen,Petra de Sutter,Anna Veiga,Hamish Wallace +19 more
TL;DR: Fertility preservation techniques have been widely adopted over the last decade and therefore the establishment of international registries on their short- and long-term outcomes is strongly recommended, and the level of evidence for most of the evidence reviewed was 3 or below.
Journal ArticleDOI
Diagnosis and treatment of infertility in men: AUA/ASRM guideline part I
Peter N. Schlegel,Mark Sigman,Barbara Collura,Christopher J. De Jonge,Michael L. Eisenberg,Dolores J. Lamb,John P. Mulhall,Craig Niederberger,Jay I. Sandlow,Rebecca Z. Sokol,Steven D. Spandorfer,Cigdem Tanrikut,Jonathan Treadwell,Jeffrey T. Oristaglio,Armand Zini +14 more
TL;DR: The presence of male infertility is crucial to the health of patients and its effects must be considered for the welfare of society.
Journal ArticleDOI
Molecular Mechanisms and Signaling Pathways Involved in Sertoli Cell Proliferation.
Silvina Beatriz Meroni,Maria Noel Lujan Galardo,Gustavo Marcelo Rindone,Agostina Gorga,Maria Fernanda Riera,Selva B. Cigorraga +5 more
TL;DR: The comprehension of how the final number of Sertoli cells in adulthood is established constitutes a pre-requisite to understand the underlying causes responsible for the progressive decrease in sperm production that has been observed during the last 50 years in humans.
References
More filters
Book
Cancer : Principles and Practice of Oncology
TL;DR: Part I: Molecular Biology of Cancer Molecular Methods in Oncology Section 1. Amplification Techniques Section 2. RNA Interference Section 3. cDNA arrays Section 4. Tissue arrays Section 5. Cytogenetics Section 6. Bioinformatics Genomics and Proteomics Molecular Targets in oncology.
Journal ArticleDOI
Pregnancies following high-dose cyclophosphamide with or without high- dose busulfan or total-body irradiation and bone marrow transplantation
Jean E. Sanders,J Hawley,Wayne C. Levy,Ted Gooley,Buckner Cd,H. J. Deeg,Kristine Doney,Rainer Storb,Keith M. Sullivan,Robert P. Witherspoon,Frederick R. Appelbaum +10 more
TL;DR: Pregnancies among all women who received a marrow transplant are likely to be accompanied by preterm labor and delivery of LBW or VLBW babies who do not seem to be at an increased risk of congenital anomalies, but determination of possible adverse effects of parental exposure to high-dose alkylating agents with or without TBI on children born posttransplant requires longer, additional follow-up.
Journal ArticleDOI
Effect of graded doses of ionizing radiation on the human testis
TL;DR: Dose-response relationships and recovery times were determined for each dose range studied and parameters evaluated included sperm concentration, motility and morphology, seminal fluid volume, plasma and urinary gonadotropin and testosterone levels, urinary estrogens.
Journal Article
Damaging Effects of Fourteen Chemotherapeutic Drugs on Mouse Testis Cells
TL;DR: The cytotoxic effects of single injections of single chemotherapeutic agents on the mouse testis did not appear to be predictive of which drugs will cause long-term azoospermia in humans.