Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.
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...Conversely, the restriction of fructose for nine days in children with a high baseline fructose intake resulted in both a reduction in liver fat and de novo lipogenesis compared to controls fed an isocaloric diet.(55) In a subset of the same study, there was also an improvement in other features of metabolic syndrome, including diastolic blood pressure, serum triglycerides and insulin resistance....
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"Effects of Dietary Fructose Restric..." refers methods in this paper
...Our data suggest that the effect of fructose on liver fat is specific and mediated through reductions in DNL. DNL was originally thought to be a minor metabolic pathway in humans.25 However, increased DNL has been demonstrated in adults with NAFLD.35 Using stable isotopes, Donnelly et al.8 showed that in adults with NAFLD, approximately 59% of triglyceride labeled in the liver comes from circulating fatty acids released by peripheral lipolysis, 15% from dietary fat, and 26% from DNL....
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...Using stable isotopes, Donnelly et al.(8) showed that in adults with NAFLD, approximately 59% of triglyceride labeled in the liver...
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