Effects of extracellular DNA on plasminogen activation and fibrinolysis
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TLDR
Extracellular DNA at physiological concentrations may potentiate fibrinolysis by stimulating fibrin-independent plasminogen activation and increases enzyme susceptibility to serpins, and DNA is a macromolecular template that both potentiates and inhibits fibrinelysis.About:
This article is published in Journal of Biological Chemistry.The article was published on 2011-12-09 and is currently open access. It has received 54 citations till now. The article focuses on the topics: Plasminogen activator & Plasmin.read more
Citations
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Journal ArticleDOI
Mechanical Stability and Fibrinolytic Resistance of Clots Containing Fibrin, DNA, and Histones
Colin Longstaff,Imre Varjú,Péter Sótonyi,László Szabó,Michael Krumrey,Armin Hoell,Attila Bóta,Zoltán Varga,Erzsébet Komorowicz,Krasimir Kolev +9 more
TL;DR: It is demonstrated that the addition of histone-DNA complexes to fibrin results in thicker fibers accompanied by improved stability and rigidity, and Therapeutic strategies could be optimized to enhance fibrinolysis in clots containing DNA and histones.
Journal ArticleDOI
The role of leukocytes in thrombosis.
TL;DR: Modulation of the interactions between leukocytes or leukocyte-derived procoagulant materials and the traditional hemostatic system is an attractive target for the development of novel antithrombotic strategies.
Journal ArticleDOI
Extracellular DNA and histones: double-edged swords in immunothrombosis.
TL;DR: The pathologic nature ofcfDNA and histones in macrovascular and microvascular thrombosis, including venous thromboembolism, cancer, sepsis, and trauma is reviewed and the prognostic value of cfDNA andhistones in these disease states is discussed.
Journal ArticleDOI
DAMP and DIC: The role of extracellular DNA and DNA-binding proteins in the pathogenesis of DIC
TL;DR: The present review gives an overview on how extracellular DNA is released into circulation and the structure of circulating DNA and summarizes the effect of ext racellular DNA and DNA-binding proteins on platelet activation, plasmatic coagulation as well as fibrinolysis.
Journal ArticleDOI
Cell-Free DNA Modulates Clot Structure and Impairs Fibrinolysis in Sepsis
Travis J. Gould,Trang T. Vu,Alan R. Stafford,Dhruva J. Dwivedi,Paul Y. Kim,Alison Fox-Robichaud,Jeffrey I. Weitz,Patricia C. Liaw +7 more
TL;DR: The studies suggest that the increased levels of CFDNA in sepsis impair fibrinolysis by inhibiting plasmin-mediated fibrin degradation, thereby identifying CFDNA as a potential therapeutic target for sepsi treatment.
References
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Journal ArticleDOI
Extracellular DNA traps promote thrombosis
Tobias A. Fuchs,Alexander Brill,Daniel Duerschmied,Daphne Schatzberg,Marc Monestier,Daniel D. Myers,Shirley K. Wrobleski,Thomas W. Wakefield,John H. Hartwig,Denisa D. Wagner +9 more
TL;DR: It is reported that NETs provide a heretofore unrecognized scaffold and stimulus for thrombus formation and may further explain the epidemiological association of infection with thrombosis.
Journal ArticleDOI
Serine protease mechanism and specificity
TL;DR: This article will review recent work on the mechanism and specificity of chymotrypsin-like enzymes, with the occasional references to pertinent experiments with subtilisin.
Journal ArticleDOI
Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.
TL;DR: The kinetic analysis suggested that the activation in the presence of fibrin occurs through binding of an activator molecule to the clot surface and subsequent addition of plasminogen (sequential ordered mechanism) to form a cyclic ternary complex.
Kinetics of the Activation of Plasminogen by Human Tissue Plasminogen Activator
TL;DR: In this paper, the activation of Gluplasminogen and Lys-minminogen in the presence of fibrinogen (f) was studied in purified systems, and the initial rate of activation (u) was calculated.
Journal ArticleDOI
U.K. Controlled trial of intrapleural streptokinase for pleural infection.
Nick A Maskell,Christopher W. H. Davies,Andrew J. Nunn,Emma L. Hedley,Fergus V. Gleeson,Robert F. Miller,Rhian Gabe,Glyn L. Rees,Tim E. A. Peto,Mark A. Woodhead,Donald J. Lane,Janet Darbyshire,Robert J. O. Davies +12 more
TL;DR: The intrapleural administration of streptokinase does not improve mortality, the rate of surgery, or the length of the hospital stay among patients with pleural infection.
Related Papers (5)
Intrapleural use of tissue plasminogen activator and DNase in pleural infection
Najib M. Rahman,Nick A Maskell,Alex West,Richard Teoh,Anthony G. Arnold,Carolyn Mackinlay,Daniel Peckham,Christopher W. H. Davies,Nabeel Ali,William Kinnear,Andrew Bentley,Brennan C Kahan,John M. Wrightson,Helen E. Davies,Clare E Hooper,Y. C. Gary Lee,Emma L. Hedley,Nicky Crosthwaite,Louise Choo,Emma J. Helm,Fergus V. Gleeson,Fergus V. Gleeson,Andrew J. Nunn,Robert J. O. Davies +23 more