Effects of infection and inflammation on lipid and lipoprotein metabolism: mechanisms and consequences to the host.
Weerapan Khovidhunkit,Min Sun Kim,Riaz A. Memon,Judy K. Shigenaga,Arthur H. Moser,Kenneth R. Feingold,Carl Grunfeld +6 more
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TLDR
APR-induced alterations initially protect the host from the harmful effects of bacteria, viruses, and parasites, however, if prolonged, these changes in the structure and function of lipoproteins will contribute to atherogenesis.About:
This article is published in Journal of Lipid Research.The article was published on 2004-07-01 and is currently open access. It has received 1328 citations till now. The article focuses on the topics: Very low-density lipoprotein & Reverse cholesterol transport.read more
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Inflammation, stress, and diabetes
TL;DR: The molecular and cellular underpinnings of obesity-induced inflammation and the signaling pathways at the intersection of metabolism and inflammation that contribute to diabetes are discussed.
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Functionally Defective High-Density Lipoprotein: A New Therapeutic Target at the Crossroads of Dyslipidemia, Inflammation, and Atherosclerosis
Anatol Kontush,M. John Chapman +1 more
TL;DR: A preferential increase in circulating concentrations of HDL particles possessing normalized antiatherogenic activity is therefore a promising therapeutic strategy for the treatment of common metabolic diseases featuring dyslipidemia, inflammation, and premature atherosclerosis.
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The immunology of atherosclerosis
Anton Gisterå,Göran K. Hansson +1 more
TL;DR: A need exists for novel therapies to stabilize plaques and to treat arterial inflammation, and patients with CKD would likely benefit from such preventive measures.
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Increased Infiltration of Macrophages in Omental Adipose Tissue Is Associated With Marked Hepatic Lesions in Morbid Human Obesity
Raffaella Cancello,Joan Tordjman,Christine Poitou,Gaël Guilhem,Jean Luc Bouillot,Danielle Hugol,Christiane Coussieu,Arnaud Basdevant,Avner Bar Hen,Pierre Bedossa,Michèle Guerre-Millo,Karine Clément +11 more
TL;DR: The data suggest that the presence of macrophages in omental WAT participates in the cellular mechanisms favoring hepatic fibroinflammatory lesions in obese patients, and the best predictive model for the severity of hepatic damage includes adiponectinemia, AST, and o mental WATmacrophages.
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Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies.
Hal M. Hoffman,Martin L. Throne,N.J. Amar,Mohamed Sebai,Alan Kivitz,Arthur Kavanaugh,Steven P. Weinstein,Pavel Belomestnov,George D. Yancopoulos,Neil Stahl,Scott Mellis +10 more
TL;DR: Treatment with weekly rilonacept provided marked and lasting improvement in the clinical signs and symptoms of CAPS, and normalized the levels of SAA from those associated with risk of developing amyloidosis.
References
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Beyond cholesterol, modifications of low-density lipoprotein that increase its atherogenicity
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Acute-Phase Proteins and Other Systemic Responses to Inflammation
Cem Gabay,Irving Kushner +1 more
TL;DR: A large number of changes, distant from the site or sites of inflammation and involving many organ systems, may accompany inflammation, and the mechanisms mediating them are becoming better understood.
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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.
TL;DR: Apolipoprotein E is a plasma protein that serves as a ligand for low density lipoprotein receptors and, through its interaction with these receptors, participates in the transport of cholesterol and other lipids among various cells of the body.
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C-reactive protein: a critical update
TL;DR: Information is provided about CRP as a protein and an acute-phase reactant, and a knowledge-based framework for interpretation and analysis of clinical observations of CRP in relation to cardiovascular and other diseases, that identifies it as a possible therapeutic target.
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The RXR heterodimers and orphan receptors
TL;DR: The historical links between the steroid and nonsteroid receptor signaling systems are established, the explosive development of the retinoid X receptor (RXR) heterodimer and orphan receptor family is charted, the impact of these discoveries on the authors' understanding of the mechanisms of hormonal signaling is explained, and emerging issues and implications are presented.