Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
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TLDR
Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
Citations
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The role of the gut microbiome and its metabolites in metabolic diseases.
TL;DR: In this paper, the authors summarized information about the role of the gut microbiome in organism metabolism and the relationship between gut microbiome-derived metabolites and the pathogenesis of many metabolic diseases, including obesity, type 2 diabetes, non-alcoholic fatty liver disease, cardiovascular disease and so on.
Journal ArticleDOI
The carbohydrate-insulin model: a physiological perspective on the obesity pandemic.
David S. Ludwig,David S. Ludwig,Louis J. Aronne,Arne Astrup,Rafael de Cabo,Lewis C. Cantley,Mark I. Friedman,Steven B. Heymsfield,James D. Johnson,Janet C. King,Ronald M. Krauss,Daniel E. Lieberman,Gary Taubes,Jeff S. Volek,Eric C. Westman,Walter C. Willett,Walter C. Willett,William S. Yancy,Cara B. Ebbeling,Cara B. Ebbeling +19 more
TL;DR: The carbohydrate-insulin model as mentioned in this paper proposes a reversal of causal direction, increasing fat deposition in the body-resulting from the hormonal responses to a high-glycemic-load diet-drives positive energy balance.
Journal ArticleDOI
The aging lung: Physiology, disease, and immunity.
Jaime L. Schneider,Jared H. Rowe,Carolina Garcia-de-Alba,Carla F. Kim,Carla F. Kim,Arlene H. Sharpe,Arlene H. Sharpe,Marcia C. Haigis +7 more
TL;DR: In this paper, the molecular and cellular aspects of lung aging, local stress response pathways, and how the aging process predisposes to the pathogenesis of pulmonary disease are discussed in the context of the COVID-19 pandemic.
Journal ArticleDOI
Food as medicine: targeting the uraemic phenotype in chronic kidney disease.
Denise Mafra,Natália A. Borges,Bengt Lindholm,Paul G. Shiels,Pieter Evenepoel,Peter Stenvinkel +5 more
TL;DR: The authors discuss the mechanisms by which food and specific nutrients could affect the uraemic phenotype in chronic kidney disease (CKD), and suggest that a food-as-medicine approach could potentially be used to prevent and treat CKD and its complications.
Journal ArticleDOI
Beneficial effects of the ketogenic diet on nonalcoholic fatty liver disease: A comprehensive review of the literature
Mikiko Watanabe,Rossella Tozzi,Renata Risi,Dario Tuccinardi,Stefania Mariani,Sabrina Basciani,Giovanni Spera,Carla Lubrano,Lucio Gnessi +8 more
TL;DR: Clinical evidence, metabolic pathways involved, and strict categorization of dietary interventions involved in the ketogenic diet and nonalcoholic fatty liver disease are focused on, to provide an accurate revision of current literature on KDs and NAFLD.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.