Journal ArticleDOI
Effects of Intermittent Fasting on Health, Aging, and Disease
Rafael de Cabo,Mark P. Mattson +1 more
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Effects of Intermittent Fasting on Health and Aging evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base fasting.Abstract:
Effects of Intermittent Fasting on Health and Aging Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger a metabolic switch from glucose-based to ketone-base...read more
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Journal ArticleDOI
Lifestyle interventions for the prevention and treatment of hypertension
Pedro L. Valenzuela,Pedro Carrera-Bastos,Beatriz G. Gálvez,Gema Ruiz-Hurtado,Jose M. Ordovas,Jose M. Ordovas,Luis M. Ruilope,Alejandro Lucia +7 more
TL;DR: Strong evidence supports the benefits of regular physical activity and exercise for the prevention and management of hypertension, and the Dietary Approaches to Stop Hypertension diet is the most effective dietary approach to prevent hypertension and to reduce blood pressure in individuals with pre-hypertension or hypertension.
Journal ArticleDOI
Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases.
TL;DR: Mounting evidence indicates that immunotherapy targeting senescent cells combats ageing and chronic diseases and subsequently extends the healthy lifespan.
Journal ArticleDOI
Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States
TL;DR: The physiological consequences of ketone bodies’ consumption are overviewed, focusing on KB-induced histone post-translational modifications, particularly β-hydroxybutyrylation and acetylation, which appears to be the core epigenetic mechanisms of activity of β-Hydroxybutyrate to modulate inflammation.
Journal ArticleDOI
Mechanisms of Lifespan Regulation by Calorie Restriction and Intermittent Fasting in Model Organisms
TL;DR: It is proposed that a systems approach combining global transcriptomic, metabolomic, and proteomic analyses followed by genetic perturbation studies targeting multiple candidate pathways will allow us to better understand how CR and fasting interact with each other to promote longevity.
Journal ArticleDOI
Circadian autophagy drives iTRF-mediated longevity.
Matt Ulgherait,Adil M. Midoun,Scarlet J. Park,Jared A. Gatto,Samantha J. Tener,Julia Siewert,Naomi Klickstein,Julie C. Canman,William W. Ja,Mimi Shirasu-Hiza +9 more
TL;DR: In this article, the authors developed an intermittent time-restricted feeding (iTRF) dietary regimen that robustly extended fly lifespan and delayed the onset of ageing markers in the muscles and gut.
References
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Journal ArticleDOI
Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys
Ricki J. Colman,Rozalyn M. Anderson,Sterling C. Johnson,Erik K. Kastman,Kristopher J. Kosmatka,T. Mark Beasley,David B. Allison,Christina Cruzen,Heather A. Simmons,Joseph W. Kemnitz,Richard Weindruch +10 more
TL;DR: Findings of a 20-year longitudinal adult-onset CR study in rhesus monkeys aimed at filling this critical gap in aging research demonstrate that CR slows aging in a primate species.
Journal ArticleDOI
Risk of dementia in diabetes mellitus: a systematic review
TL;DR: The findings of mechanistic studies suggest that vascular disease and alterations in glucose, insulin, and amyloid metabolism underlie the pathophysiology of dementia, but which of these mechanisms are clinically relevant is unclear.
Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Starvation in man.
TL;DR: In this article, it was shown that decreased levels of active T3 may play a role by sparing otherwise obligated calories by decreasing metabolic needs, but this can be nullified by amino acid or protein supplementation.
Journal ArticleDOI
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network.
TL;DR: The results point to a central role for the PGC-1 family in integrating mitochondrial biogenesis and energy production with many diverse cellular functions.