Journal ArticleDOI
Effects of local hypothermia and tissue oxygen studies in experimental paraplegia
Reads0
Chats0
TLDR
It is postulated that local hypothermia may be effective in altering the clinical recovery by decreasing the tissue metabolism at the site of injury.Abstract:
✓ A controlled series of adult mongrel dogs were rendered paraplegic by traumatizing the thoracic spinal cord. Those animals treated with local hypothermia, whether immediately or after a delay, recovered to a significantly greater degree than the untreated group. Spinal cord pO2 studies revealed a marked fall in the pO2 at the area of maximal injury over a 30-min period. The severe hypoxia lasted at least 7 hours. Pathological studies showed the varying degrees of injury produced. It is postulated that local hypothermia may be effective in altering the clinical recovery by decreasing the tissue metabolism at the site of injury.read more
Citations
More filters
Journal ArticleDOI
Pathophysiology of “tethered cord syndrome”
TL;DR: The well-known finding of elongated spinal cord attached to the tight filum or a tumor is not always demonstrated in imaging studies, and understanding of pathophysiology allows physicians to correctly diagnose and treat patients with tethered cord syndrome.
Journal ArticleDOI
Spinal cord contusion in the rat: Behavioral analysis of functional neurologic impairment
TL;DR: The protocol used for neurologic assessment was administered routinely by personnel who were easily and rapidly trained and should prove useful in detecting the effects of treatment on recovery of function in a rat model of spinal cord injury.
Journal ArticleDOI
Pathophysiology of spinal cord trauma
TL;DR: A speculative etiopathogenesis of secondary injury is presented in an attempt to explain the importance and order of the pathophysiologic events that result in tissue death and the apparent effectiveness of diverse pharmacologic agents in the treatment of experimental spinal cord injury.
Journal ArticleDOI
The pathophysiological response to spinal cord injury. The current status of related research.
TL;DR: This review of spinal cord injury research has placed special emphasis on the controversial issues appropriate to a new, stimulating, and competitive area of research.
Journal ArticleDOI
Altered norepinephrine metabolism following experimental spinal cord injury. 1. Relationship to hemorrhagic necrosis and post-wounding neurological deficits.
TL;DR: It is hypothesized that toxic quantities of tissue NE induce intense vasospasm which impedes or arrests cord perfusion and causes the neuronal necrosis, vascular rupture, and parenchymal self-destruction manifest as central hemorrhagic necrosis.
References
More filters
Journal ArticleDOI
Surgery of experimental lesion of spinal cord equivalent to crush injury of fracture dislocation of spinal column: a preliminary report
TL;DR: In order to arrive at an adequate concept as to the amount of impact a spinal cord could receive and yet recover its function, I designed an instrument whereby a given weight could be placed on the cord.
Journal ArticleDOI
Microelectrodes for measuring local oxygen tension in animal tissues
Philip W. Davies,Frank Brink +1 more
TL;DR: Two types of stationary platinum microelectrodes which electrolyze dissolved oxygen when suitable potentials are applied are described, which are possible to measure the oxygen tension in an open solution, and especially, to estimate local oxygen tensions in animal tissues.
Journal ArticleDOI
Experimental Treatments of Acute Spinal Cord Injury
Thomas B. Ducker,Harold F. Hamit +1 more
TL;DR: Standard dural decompression, direct local cord hypothermia, intramuscular dexamethasone, and intrathecal methylprednisolone are evaluated.
Journal ArticleDOI
Study of functional recovery produced by delayed localized cooling after spinal cord injury in primates.
TL;DR: In reviewing other approaches to the problem of spinal cord injury, the authors were impressed with some of the work relating to the protective effect of cold on brain, and an attempt has been made to assess the practical advantages of direct laminectomy in patients displaying sensory-motor paralysis.