Effects of long-continued ingestion of zinc sulphate in patients with venous leg ulceration.
TL;DR: No haematological or biochemical evidence of zinc toxicity was detected during the period of zinc administration, but further studies of the long-term effects of zinc therapy are required.
About: This article is published in The Lancet.The article was published on 1970-10-31. It has received 98 citations till now. The article focuses on the topics: Zinc toxicity.
Citations
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Tufts University1, University of Alabama at Birmingham2, University of Michigan3, Indiana University4, Lund University5, University of Illinois at Chicago6, Uniformed Services University of the Health Sciences7, Mayo Clinic8, University of North Carolina at Chapel Hill9, Oregon Health & Science University10, Medical University of Vienna11, University of Texas Health Science Center at San Antonio12, Harvard University13, Duke University14
TL;DR: Thomas F. O'Donnell, MD, Marc A. Passman and Peter K. Gloviczki as mentioned in this paper, MD, PhD, Bo G. Eklof et al.
497 citations
Journal Article•
TL;DR: To promote wound healing in the shortest time possible, with minimal pain, discomfort, and scarring to the patient, it is important to explore nutritional and botanical influences on wound outcome.
Abstract: Healing of wounds, whether from accidental injury or surgical intervention, involves the activity of an intricate network of blood cells, tissue types, cytokines, and growth factors. This results in increased cellular activity, which causes an intensified metabolic demand for nutrients. Nutritional deficiencies can impede wound healing, and several nutritional factors required for wound repair may improve healing time and wound outcome. Vitamin A is required for epithelial and bone formation, cellular differentiation, and immune function. Vitamin C is necessary for collagen formation, proper immune function, and as a tissue antioxidant. Vitamin E is the major lipid-soluble antioxidant in the skin; however, the effect of vitamin E on surgical wounds is inconclusive. Bromelain reduces edema, bruising, pain, and healing time following trauma and surgical procedures. Glucosamine appears to be the rate-limiting substrate for hyaluronic acid production in the wound. Adequate dietary protein is absolutely essential for proper wound healing, and tissue levels of the amino acids arginine and glutamine may influence wound repair and immune function. The botanical medicines Centella asiatica and Aloe vera have been used for decades, both topically and internally, to enhance wound repair, and scientific studies are now beginning to validate efficacy and explore mechanisms of action for these botanicals. To promote wound healing in the shortest time possible, with minimal pain, discomfort, and scarring to the patient, it is important to explore nutritional and botanical influences on wound outcome.
424 citations
TL;DR: Much work remains to be done to establish the normal levels of most trace elements in blood plasma or serum of apparently healthy individuals, and the development of adequate measures for contamination control is the most important prerequisite.
361 citations
TL;DR: Investigation of the healing of chronic venous leg ulcers in patients with a serum-zinc level and to the effect of an effervescent preparation of oral zinc sulphate or placebo found no haematological or biochemical evidence of toxicity during 4 months of zinc administration.
258 citations
TL;DR: This study was undertaken to determine the relative prevalence of the factors causing chronic ulceration of the leg in the general population of Western Australian and found venous disease was the most prevalent cause of ulcerations.
168 citations
References
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376 citations
TL;DR: Plasma-zinc levels were measured by atomic-absorption spectrophotometry in healthy adults and children, in patients with a variety of diseases, in pregnancy, and in women taking oral contraceptives with no significant variation attributable to sex, food consumption, or diurnal variation.
324 citations
TL;DR: The need for zinc in the optimal healing of wounds was demonstrated by the acceleration of healing of granulating wounds caused by excision of pilonidal-sinus tracts in young, healthy airmen who were given zinc sulphate U.S.P. by mouth during the period of repair.
245 citations
126 citations
TL;DR: Sera from patients with liver or bone diseases showed patterns of activity specific for each group of patients, and methods for differentiating alkaline phosphatase in serum and tissue extracts by starch gel electrophoresis are described.
118 citations