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Journal ArticleDOI

Effects of TiO2 nanotubes with different diameters on gene expression and osseointegration of implants in minipigs.

01 Oct 2011-Biomaterials (Biomaterials)-Vol. 32, Iss: 29, pp 6900-6911
TL;DR: TiO(2) nanotubes can modulate bone formation events at the bone-implant interface as to reach favorable molecular response and osseointegration and the diameters of nanot tubes can be precisely controlled in order to obtain better bone formation.
About: This article is published in Biomaterials.The article was published on 2011-10-01. It has received 279 citations till now. The article focuses on the topics: Osseointegration & Implant.
Citations
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Journal ArticleDOI
TL;DR: Titanium dioxide (TiO2) has been the most intensively investigated binary transition metal oxide in the past four decades and the annual number of papers published on TiO2 has seen a continuous increase, particularly since the beginning of this century.
Abstract: Titanium dioxide (TiO2) has been the most intensively investigated binary transition metal oxide in the past four decades as indicated by Figure S1. Furthermore, the annual number of papers published on TiO2 has seen a continuous increase, particularly since the beginning of this century (Figure S2). This is understandable when one considers the wide range of applications of TiO2 from the conventional areas (i.e., pigment, cosmetic, toothpaste, and paint) to the later developed functional areas such as photoelectrochemical cell,(1-3) dye-sensitized solar cells (DSSCs),(4-11) photocatalysis,(12-24) catalysis,(25-31) photovoltaic cell,(32-34) lithium ion batteries,(35-41) sensors,(42-46) electron field emission,(47-51) microwave absorbing material, biomimetic growth, and biomedical treatments.(52-57) Nearly all these functional applications of TiO2 fall in the scope of energy, environment, and health, which are definitely the three most important and challenging themes facing the Human race that need to be addressed in this century. Besides the apparent merits including nontoxicity, elemental abundance, good chemical stability, and easy synthesis, TiO2 has attracted strong research interest worldwide due to its physicochemical properties for realizing various functions.(15, 58, 59) Especially, very encouraging progresses in photocatalysis and DSSCs with the involvement of TiO2 have greatly stimulated the rapid development of TiO2 crystals with controllable phase, size, shape, defect, and heteroatom.(58, 60-68)

880 citations

Journal ArticleDOI
TL;DR: Considering mechanical and physical properties similar to bone, PEEK can be used in many areas of dentistry and further modifications and improving the material properties may increase its applications in clinical dentistry.

564 citations

Journal ArticleDOI
TL;DR: The NT-Ag2O arrays can effectively kill Escherichia coli and Staphylococcus aureus even after immersion for 28 days, demonstrating the long lasting antibacterial ability.

292 citations

Journal ArticleDOI
TL;DR: An improvement in wettability and bioactivity of titanium implant surfaces has been accomplished by combining micro and nano-scale modification and functionalization with protein, peptides, and bioactive compounds.

280 citations

Journal ArticleDOI
TL;DR: T titania nanotubes 25 and 80 nm in size with the acid-etched Ti topography and hierarchical hybrid micropitted/nanotubular topographies are produced to mimic the structure of the natural bone extracellular matrix, showing the best ability to simultaneously promote MSC proliferation and osteogenic differentiation.

271 citations

References
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Journal ArticleDOI
25 Aug 2006-Cell
TL;DR: Naive mesenchymal stem cells are shown here to specify lineage and commit to phenotypes with extreme sensitivity to tissue-level elasticity, consistent with the elasticity-insensitive commitment of differentiated cell types.

12,204 citations

Journal ArticleDOI
11 Jan 2002-Cell
TL;DR: It is proposed that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells, because Osx null preostEoblasts express typical chondrocyte marker genes, and Osx acts downstream of Runx 2/C bfa1.

3,283 citations


"Effects of TiO2 nanotubes with diff..." refers background in this paper

  • ...Osx-deficient mice show absence of osteoblasts and defective bone formation [34]....

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Journal ArticleDOI
TL;DR: In this article, the average tube diameter, ranging in size from 25 to 65 nm, was found to increase with increasing anodizing voltage, while the length of the tube was found independent of anodization time.
Abstract: Titanium oxide nanotubes were fabricated by anodic oxidation of a pure titanium sheet in an aqueous solution containing 0.5 to 3.5 wt% hydrofluoric acid. These tubes are well aligned and organized into high-density uniform arrays. While the tops of the tubes are open, the bottoms of the tubes are closed, forming a barrier layer structure similar to that of porous alumina. The average tube diameter, ranging in size from 25 to 65 nm, was found to increase with increasing anodizing voltage, while the length of the tube was found independent of anodization time. A possible growth mechanism is presented.

1,975 citations


"Effects of TiO2 nanotubes with diff..." refers methods in this paper

  • ...After being treated with controlled anodizing method, a selforganized and highly ordered coating of Ti and Ti-based alloyseTiO2 nanotubes was produced [6]....

    [...]

Journal ArticleDOI
TL;DR: Osseointegration is the stable anchorage of an implant achieved by direct bone-to-implant contact in craniofacial implantology and this mode of anchorage is the only one for which high success rates have been reported.
Abstract: Osteoinduction is the process by which osteogenesis is induced. It is a phenomenon regularly seen in any type of bone healing process. Osteoinduction implies the recruitment of immature cells and the stimulation of these cells to develop into preosteoblasts. In a bone healing situation such as a fracture, the majority of bone healing is dependent on osteoinduction. Osteoconduction means that bone grows on a surface. This phenomenon is regularly seen in the case of bone implants. Implant materials of low biocompatibility such as copper, silver and bone cement shows little or no osteoconduction. Osseointegration is the stable anchorage of an implant achieved by direct bone-to-implant contact. In craniofacial implantology, this mode of anchorage is the only one for which high success rates have been reported. Osseointegration is possible in other parts of the body, but its importance for the anchorage of major arthroplasties is under debate. Ingrowth of bone in a porous-coated prosthesis may or may not represent osseointegration.

1,527 citations


"Effects of TiO2 nanotubes with diff..." refers background in this paper

  • ...Contact osteogenesis relies upon osteoconduction, or the recruitment and migration of differentiating osteogenic cells to the implant surface, together with de novo bone formation by those cells on the implant surface or down into pores or pipes [30,44]....

    [...]

  • ...After implantation, the formation of mineralized bone near implant surface requires the colonization of implant surface by osteoblastic cells, these cells mainly originate from mesenchymal stem cells (MSCs) recruited by implant surface [30,31]....

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Journal ArticleDOI
TL;DR: Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media.
Abstract: Two important goals in stem cell research are to control the cell proliferation without differentiation and to direct the differentiation into a specific cell lineage when desired. Here, we demonstrate such paths by controlling only the nanotopography of culture substrates. Altering the dimensions of nanotubular-shaped titanium oxide surface structures independently allowed either augmented human mesenchymal stem cell (hMSC) adhesion or a specific differentiation of hMSCs into osteoblasts by using only the geometric cues, absent of osteogenic inducing media. hMSC behavior in response to defined nanotube sizes revealed a very dramatic change in hMSC behavior in a relatively narrow range of nanotube dimensions. Small (≈30-nm diameter) nanotubes promoted adhesion without noticeable differentiation, whereas larger (≈70- to 100-nm diameter) nanotubes elicited a dramatic stem cell elongation (≈10-fold increased), which induced cytoskeletal stress and selective differentiation into osteoblast-like cells, offering a promising nanotechnology-based route for uniqueorthopedics-related hMSC treatments.

1,110 citations


"Effects of TiO2 nanotubes with diff..." refers background in this paper

  • ...It is well known that various kinds of physical stresses from the substrate morphology and topography can accelerate stem cell differentiation into a specific cell lineage [14,19,21,40,41], and our study has...

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