Journal ArticleDOI
Efficacy and safety of once-daily QVA149 compared with twice-daily salmeterol-fluticasone in patients with chronic obstructive pulmonary disease (ILLUMINATE): a randomised, double-blind, parallel group study.
Claus Vogelmeier,Eric D. Bateman,John Pallante,Vijay Alagappan,Peter D'Andrea,Hungta Chen,Donald Banerji +6 more
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TLDR
Once-daily QVA149 provides significant, sustained, and clinically meaningful improvements in lung function versus twice-daily SFC, with significant symptomatic benefit, indicating the potential of dual bronchodilation as a treatment option for non-exacerbating symptomatic COPD patients.About:
This article is published in The Lancet Respiratory Medicine.The article was published on 2013-03-01. It has received 290 citations till now. The article focuses on the topics: Indacaterol & Bronchodilator.read more
Citations
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Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Indacaterol–Glycopyrronium versus Salmeterol–Fluticasone for COPD
Jadwiga A. Wedzicha,Donald Banerji,Kenneth R. Chapman,Jørgen Vestbo,Nicolas Roche,R Timothy Ayers,Chau Thach,Robert Fogel,Francesco Patalano,Claus Vogelmeier +9 more
TL;DR: Indacaterol-glycopyrronium was more effective than salmeterol-fluticasone in preventing COPD exacerbations in patients with a history of exacerbation during the previous year and showed not only noninferiority but also superiority in reducing the annual rate of all COPd exacerbations.
Journal ArticleDOI
Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study
Eric D. Bateman,Gary T. Ferguson,Neil Barnes,Nicola Gallagher,Yulia Green,Michelle Henley,Donald Banerji +6 more
TL;DR: Dual bronchodilation with once-daily QVA149 demonstrated superior and clinically meaningful outcomes versus placebo and superiority versus treatment with a single Bronchodilator, with a safety and tolerability profile similar to placebo, supporting the concept of fixed-dose long-acting muscarinic antagonist/long-acting &bgr;2-agonist combinations for the treatment of COPD.
Journal ArticleDOI
Prevention of Acute Exacerbations of COPD: American College of Chest Physicians and Canadian Thoracic Society Guideline
Gerard J. Criner,Jean Bourbeau,Rebecca L. Diekemper,Daniel R. Ouellette,Donna Goodridge,Paul Hernandez,Kristen Curren,Meyer Balter,Mohit Bhutani,Pat G. Camp,Bartolome R. Celli,Gail Dechman,Mark T. Dransfield,Stanley B. Fiel,Marilyn G. Foreman,Nicola A. Hanania,Belinda K. Ireland,Nathaniel Marchetti,Darcy D Marciniuk,Richard A. Mularski,Joseph Ornelas,Jeremy Road,Michael K. Stickland +22 more
TL;DR: This guideline is unique because it provides an up-to-date, rigorous, evidence-based analysis of current randomized controlled trial data regarding the prevention of COPD exacerbations.
Journal ArticleDOI
Spanish Guideline for COPD (GesEPOC). Update 2014
Marc Miravitlles,Juan José Soler-Cataluña,Myriam Calle,Jesús Molina,Pere Almagro,José Antonio Quintano,Juan Antonio Riesco,Juan Antonio Trigueros,Pascual Piñera,Adolfo Simón,Juan Luis Rodríguez-Hermosa,Esther Marco,Daniel Barba López,Ramon Coll,Roser Coll-Fernández,Miguel Ángel Lobo,Jesús Díez,Joan B. Soriano,Julio Ancochea +18 more
TL;DR: This research presents a meta-anatomy of the neumologia and physiology of the connective tissue of the autonomic nervous system, which has been studied in detail in the context of chronic illness and rehabilitation.
References
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Journal ArticleDOI
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary.
Jørgen Vestbo,Suzanne S. Hurd,Alvar Agusti,Paul W. Jones,Claus Vogelmeier,Antonio Anzueto,Peter J. Barnes,Leonardo M. Fabbri,Fernando J. Martinez,Masaharu Nishimura,Robert A. Stockley,Don D. Sin,Roberto Rodriguez-Roisin +12 more
TL;DR: It is recommended that spirometry is required for the clinical diagnosis of COPD to avoid misdiagnosis and to ensure proper evaluation of severity of airflow limitation.
Journal ArticleDOI
Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease.
Julie A. Anderson,Bartolome R. Celli,Gary T. Ferguson,Christine Jenkins,Paul W. Jones,Julie C. Yates,Jørgen Vestbo +6 more
TL;DR: The reduction in death from all causes among patients with COPD in the combination-therapy group did not reach the predetermined level of statistical significance, and there were significant benefits in all other outcomes among these patients.
Journal ArticleDOI
Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
John R. Hurst,Jørgen Vestbo,Jørgen Vestbo,Antonio Anzueto,Nicholas Locantore,Hana Müllerová,Ruth Tal-Singer,Bruce E. Miller,David A. Lomas,Alvar Agusti,William MacNee,Peter M.A. Calverley,Stephen I. Rennard,Emiel F.M. Wouters,Jadwiga A. Wedzicha +14 more
TL;DR: Although exacerbations become more frequent and more severe as COPD progresses, the rate at which they occur appears to reflect an independent susceptibility phenotype, which has implications for the targeting of exacerbation-prevention strategies across the spectrum of disease severity.
Journal ArticleDOI
Antibiotic Therapy in Exacerbations of Chronic Obstructive Pulmonary Disease
Nicholas R. Anthonisen,Jure Manfreda,C. P. W. Warren,Earl Hershfield,G. K. M. Harding,N. A. Nelson +5 more
TL;DR: There was a significant benefit associated with antibiotic and Peak flow recovered more rapidly with antibiotic treatment than with placebo, and side effects were uncommon and did not differ between antibiotic and placebo.
Journal ArticleDOI
A systematic review of the associations between dose regimens and medication compliance
TL;DR: A review of studies that measured compliance using EM confirmed that the prescribed number of doses per day is inversely related to compliance.