Efficacy of Andrographis paniculata compared to Azadirachta indica, Curcuma longa, and sodium hypochlorite when used as root canal irrigants against Candida albicans and Staphylococcus aureus: An in vitro antimicrobial study.
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TLDR
Zones of inhibition exhibited by novel herbal agent A. paniculata were higher against C. albicans and similar against S. aureus, when compared to NaOCl.Abstract:
Aim: The aim is to test the antimicrobial activity of Andrographis Paniculata, Azadirachta indica (neem), and Curcuma Longa (curcumin) as a root canal irrigant, against Staphylococcus aureus and Candida albicans using agar diffusion test. Sodium hypochlorite (NaOCl) served as a standard control for comparisons. Materials and Methods: The bacterial strains of C. albicans and S. aureus culture were grown overnight (18–20 h) in the brain heart infusion broth at 37°C and inoculated in Mueller–Hinton agar plates. Antibacterial inhibition was assessed using agar well-diffusion method using the methanolic extracts of the three plants to be tested and NaOCl. Bacterial inhibition zone around each well was recorded. The results were tabulated and analyzed statistically for significance. Results: The novel A. paniculata showed significantly higher zone of inhibition against C. albicans (P 0.05). Conclusion: Zones of inhibition exhibited by novel herbal agent A. paniculata were higher against C. albicans and similar against S. aureus, when compared to NaOCl.read more
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References
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Antifungal activity of Andrographis paniculata extracts and active principles against skin pathogenic fungal strains in vitro
Abubakar Sule,Qamar Uddin Ahmed,Jalifah Latip,Othman Abd. Samah,Muhammad Nor Omar,Abdulrashid Umar,Bashar Bello S. Dogarai +6 more
TL;DR: This is the first report on the isolation of antifungal substances through bioassay-guided assay from A. paniculata, and justifies the use of A.paniculata in folk medicines for the treatment of fungal skin infections.
Journal ArticleDOI
In Vitro Evaluation of the Antimicrobial Efficacy of Four Endodontic Biomaterials against Enterococcus faecalis, Candida albicans, and Staphylococcus aureus
Duddi Narendra Nirupama,Mohan Thomas Nainan,Rajendran Ramaswamy,Sethumadhavan Muralidharan,Hulimangala Hosakote Lingareddy Usha,Roshni Sharma,Soham Gupta +6 more
TL;DR: This study evaluated the antimicrobial activity of four endodontic sealers, AH Plus, Tubliseal EWT, EndoRez, and iRoot SP, against three different microorganisms, E. faecalis, C. albicans, and S. aureus, by direct contact test.
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Phytochemical screening and antimicrobial activity of ethanolic extract of Andrographis paniculata
V Rajalakshmi,L Cathrine +1 more
TL;DR: The ethanolic extract of leaves of Andrographis Paniculata exhibited antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis and antifungal activity against Candida albicans, As pergillus niger and Aspergillus flavus.
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