Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study
Jean-Michel Molina,Jean-Michel Molina,Isabelle Charreau,Bruno Spire,Laurent Cotte,Julie Chas,Catherine Capitant,Cécile Tremblay,Daniela Rojas-Castro,Eric Cua,Armelle Pasquet,Camille Bernaud,Claire Pintado,Constance Delaugerre,Constance Delaugerre,Luis Sagaon-Teyssier,Soizic Le Mestre,Christian Chidiac,Gilles Pialoux,Diane Ponscarme,Julien Fonsart,David Thompson,Mark A. Wainberg,Véronique Doré,Laurence Meyer,Laurence Meyer,Laurence Meyer,C Capitant,I Charreau,Emmanuelle Netzer,N Leturque,J Binesse,V. Foubert,M Saouzanet,F Euphrasie,Diane Carette,B Guillon,Y Saïdi,J P Aboulker,B Spire,M Suzan,G Cattin,Baptiste Demoulin,L Sagaon-Teyssier,Nicolas Lorente,V Doré,E Choucair,S Le Mestre,A Mennecier,N. Etien,M C Simon,A Diallo,S Gibowski,Jean-François Delfraissy,D Thompson,Jacquie Sas,J Pankovitch,Marina B. Klein,A Anis,Benoit Trottier,Jean-Guy Baril,Antoine Chéret,Michel Besnier,W. Rozenbaum,Nathalie Bajos,Julie Timsit,Gilles Peytavin,Isabelle Durand-Zaleski,Jean-Pierre Aboulker,Marie Suzan-Monti,Gabriel Girard,Daniela Rojas Castro,Marie Préau,Michel Morin,Anaïs Mennecier,Elias Choucair,Marie-Christine Simon,Joanne Otis,Alpha Diallo,Séverine Gibowski,Cecile Rabian +80 more
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TLDR
On-demand oral PrEP is highly effective at preventing HIV infection among high-risk men who have sex with men and therefore represents an alternative to daily PrEP, expanding choices for HIV prevention.About:
This article is published in The Lancet HIV.The article was published on 2017-09-01 and is currently open access. It has received 348 citations till now. The article focuses on the topics: Pre-exposure prophylaxis & Men who have sex with men.read more
Citations
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Journal ArticleDOI
Sexually Transmitted Infections Treatment Guidelines,2021
Kimberly A. Workowski,Laura H. Bachmann,Philip A. Chan,Christine Johnston,Christina A. Muzny,Ina U. Park,Hilary Reno,Jonathan M. Zenilman,Gail Bolan +8 more
TL;DR: These guidelines for the treatment of persons who have or are at risk for sexually transmitted infections (STIs) were updated by CDC after consultation with professionals knowledgeable in the field of STIs who met in Atlanta, Georgia, June 11-14, 2019.
Journal ArticleDOI
Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society–USA Panel
Michael S. Saag,Constance A. Benson,Rajesh T. Gandhi,Jennifer F Hoy,Raphael J. Landovitz,Michael J. Mugavero,Paul E. Sax,Davey M. Smith,Melanie A. Thompson,Susan Buchbinder,Carlos del Rio,Joseph J. Eron,Gerd Fätkenheuer,Huldrych F. Günthard,Jean-Michel Molina,Donna M. Jacobsen,Paul A. Volberding +16 more
TL;DR: Advances in HIV prevention and treatment with antiretroviral drugs continue to improve clinical management and outcomes for individuals at risk for and living with HIV.
Journal ArticleDOI
Population-level effectiveness of rapid, targeted, high-coverage roll-out of HIV pre-exposure prophylaxis in men who have sex with men: the EPIC-NSW prospective cohort study.
Andrew E. Grulich,Rebecca Guy,Janaki Amin,Fengyi Jin,Christine Selvey,Jo Holden,Heather Marie A. Schmidt,Iryna Zablotska,Karen Price,Bill Whittaker,Kerry Chant,Craig Cooper,Scott McGill,Barbara Telfer,Barbara Yeung,Gesalit Levitt,Erin Ogilvie,Nila J. Dharan,Mohamed A. Hammoud,Stefanie Vaccher,Lucy Watchirs-Smith,Anna McNulty,David Smith,Debra M. Allen,David Baker,Mark Bloch,Rohan I. Bopage,Katherine Brown,Andrew Carr,Christopher J. Carmody,Kym L. Collins,Robert Finlayson,Rosalind Foster,Eva Jackson,David A. Lewis,Josephine Lusk,Catherine C O'Connor,Nathan Ryder,Emanuel Vlahakis,Phillip Read,David A. Cooper +40 more
TL;DR: PrEP implementation was associated with a rapid decline in HIV diagnoses in the state of New South Wales, which was greatest for recent infections.
Journal ArticleDOI
Emtricitabine and tenofovir alafenamide vs emtricitabine and tenofovir disoproxil fumarate for HIV pre-exposure prophylaxis (DISCOVER): primary results from a randomised, double-blind, multicentre, active-controlled, phase 3, non-inferiority trial.
Kenneth H. Mayer,Kenneth H. Mayer,Jean-Michel Molina,Melanie A. Thompson,Peter L. Anderson,Karam Mounzer,Joss J De Wet,Edwin DeJesus,Heiko Jessen,Robert M. Grant,Peter Ruane,Pamela Wong,Ramin Ebrahimi,Lijie Zhong,Anita Mathias,Christian Callebaut,Sean E Collins,Moupali Das,Scott McCallister,Diana M. Brainard,Cynthia Brinson,Amanda Clarke,Pep Coll,Frank A. Post,C. Bradley Hare +24 more
TL;DR: Primary results from a blinded phase 3 study evaluating the efficacy and safety of pre-exposure prophylaxis (PrEP) with emtricitabine and tenofovir alafenamide versus emticitabines and ten ofovir disoproxil fumarate for HIV prevention are reported.
Journal ArticleDOI
Post-exposure prophylaxis with doxycycline to prevent sexually transmitted infections in men who have sex with men: an open-label randomised substudy of the ANRS IPERGAY trial.
Jean-Michel Molina,Isabelle Charreau,Christian Chidiac,Gilles Pialoux,Eric Cua,Constance Delaugerre,Catherine Capitant,Daniela Rojas-Castro,Julien Fonsart,Béatrice Berçot,Cécile Bébéar,Laurent Cotte,Olivier Robineau,François Raffi,Pierre Charbonneau,Alexandre Aslan,Julie Chas,Laurence Niedbalski,Bruno Spire,Luis Sagaon-Teyssier,Diane Carette,Soizic Le Mestre,Véronique Doré,Laurence Meyer,Laurence Meyer,Claire Pintado,B. Loze,C. Gatey,D. Ponscarme,P. Penot,R. Veron,J. Delgado,E. Dalle,S. Parlier,I. Madelaine,M. Danet,N. Mahjoub,N. Mezreb,K. Moudachirou,Stéphane Morel,G. Conort,F. Lorho,M. Meunier,W. Rozenbaum,C. Monfort,J. Foucoin,B. Boissavy,S. Cousseau,S. Huon,A. Djessima,V. Berrebi,A. Adda,S. le Nagat,L. Zarka,J. Berdougo,Naoufel Mzoughi,F. Clement,A. Decouty,C. Chapolard,M. Godinot,C. Adouard-groslafeige,J. Koffi,A. Pansu,A. Becker,S. Pailhes,F. Bonnet,F. Jeanblanc,C. Brochier,X. Teruin,S. Rouby,L. Gilly,C. Etienne,F. Tolonin,S. Breaud,V. Péchenot,S. Bagge,T. Cepitelli,Pm. Roger,E. Rosenthal,A Cheret,P. Cornavin,S. Vandamme,J. Lambec,N. Dumon,O. Leclanche,T. Huleux,R. Biekre,H. Melliez,H. Bazus,Armelle Pasquet,C. Bernaud,Michel Besnier,B. Bonnet,N. Hall,M. Cavellec,H. Hue,L. Larmet,M. Colas,Rémy Choquet,S Fouéré,Emmanuelle Netzer,N Leturque,J Binesse,V. Foubert,M Saouzanet,F Euphrasie,B Guillon,Y Saïdi,M Suzan,G Cattin,Baptiste Demoulin,Nicolas Lorente +111 more
TL;DR: Doxycycline PEP reduced the occurrence of a first episode of bacterial STI in high-risk men who have sex with men in this open-label randomised study.
References
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Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
TL;DR: Oral FTC-TDF provided protection against the acquisition of HIV infection among the subjects and Detectable blood levels strongly correlated with the prophylactic effect.
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Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Jared M. Baeten,Deborah Donnell,Deborah Donnell,Patrick Ndase,Nelly Mugo,Nelly Mugo,James D. Campbell,Jonathan Wangisi,Jordan W. Tappero,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,Allan R. Ronald,Elioda Tumwesigye,Edwin Were,Kenneth H. Fife,James Kiarie,James Kiarie,Carey Farquhar,Grace John-Stewart,Aloysious Kakia,Josephine Odoyo,Akasiima Mucunguzi,Edith Nakku-Joloba,Rogers Twesigye,Kenneth Ngure,Cosmas Apaka,Harrison Tamooh,Fridah Gabona,Andrew Mujugira,Dana Panteleeff,Katherine K. Thomas,Lara Kidoguchi,Meighan Krows,Jennifer Revall,Susan Morrison,Harald S. Haugen,Mira Emmanuel-Ogier,Lisa Ondrejcek,Robert W. Coombs,Lisa M. Frenkel,Lisa M. Frenkel,Craig W. Hendrix,Namandjé N. Bumpus,David R. Bangsberg,Jessica E. Haberer,Wendy S. Stevens,Jairam R. Lingappa,Connie Celum +49 more
TL;DR: Oral TDF and TDF-FTC both protect against HIV-1 infection in heterosexual men and women, and both study medications significantly reduced the HIV- 1 incidence among both men andWomen.
Journal ArticleDOI
Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women
Quarraisha Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Salim S. Abdool Karim,Janet A. Frohlich,Anneke Grobler,Cheryl Baxter,Leila E. Mansoor,Ayesha B. M. Kharsany,Sengeziwe Sibeko,Koleka Mlisana,Zaheen Omar,Tanuja N. Gengiah,Silvia Maarschalk,Natasha Arulappan,Mukelisiwe Mlotshwa,Lynn Morris,Douglas Taylor +17 more
TL;DR: Tenofovir in a vaginal gel formulation shows significant protection against HIV infection in a randomized control trial, and could potentially fill an important HIV prevention gap, especially for women unable to successfully negotiate mutual monogamy or condom use.
Journal ArticleDOI
Antiretroviral preexposure prophylaxis for heterosexual HIV transmission in Botswana.
Michael C. Thigpen,Poloko Kebaabetswe,Lynn A. Paxton,Dawn K. Smith,Charles E. Rose,Tebogo M. Segolodi,Faith L. Henderson,Sonal R Pathak,Fatma A. Soud,Kata Chillag,Rodreck Mutanhaurwa,Lovemore Ian Chirwa,Michael Kasonde,Daniel Abebe,Evans Buliva,Roman Gvetadze,Sandra H. Johnson,Thom Sukalac,Vasavi Thomas,Clyde E. Hart,Jeffrey A. Johnson,C. Kevin Malotte,Craig W. Hendrix,John T. Brooks +23 more
TL;DR: Daily TDF-FTC prophylaxis prevented HIV infection in sexually active heterosexual adults and had a significant decline in bone mineral density, which remains unknown.
Journal ArticleDOI
Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial.
Sheena McCormack,David Dunn,Monica Desai,David Dolling,Mitzy Gafos,Richard Gilson,Richard Gilson,Ann Sullivan,Amanda Clarke,Iain Reeves,Gabriel Schembri,Nicola Mackie,Christine Bowman,Charles J.N. Lacey,Vanessa Apea,Michael Brady,Julie Fox,Stephen Taylor,Simone Antonucci,Saye Khoo,James F. Rooney,Anthony Nardone,Martin Fisher,Alan McOwan,Andrew N. Phillips,Anne M Johnson,Brian Gazzard,ON Gill +27 more
TL;DR: In this high incidence population, daily tenofovir–emtricitabine conferred even higher protection against HIV than in placebo-controlled trials, refuting concerns that effectiveness would be less in a real-world setting.
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Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial.
Sheena McCormack,David Dunn,Monica Desai,David Dolling,Mitzy Gafos,Richard Gilson,Richard Gilson,Ann Sullivan,Amanda Clarke,Iain Reeves,Gabriel Schembri,Nicola Mackie,Christine Bowman,Charles J.N. Lacey,Vanessa Apea,Michael Brady,Julie Fox,Stephen Taylor,Simone Antonucci,Saye Khoo,James F. Rooney,Anthony Nardone,Martin Fisher,Alan McOwan,Andrew N. Phillips,Anne M Johnson,Brian Gazzard,ON Gill +27 more
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
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Kachit Choopanya,Michael Martin,Michael Martin,Pravan Suntharasamai,Udomsak Sangkum,Philip A. Mock,Manoj Leethochawalit,Sithisat Chiamwongpaet,Praphan Kitisin,Pitinan Natrujirote,Somyot Kittimunkong,Rutt Chuachoowong,Roman Gvetadze,Janet M. McNicholl,Janet M. McNicholl,Lynn A. Paxton,Marcel E. Curlin,Marcel E. Curlin,Craig W. Hendrix,Suphak Vanichseni +19 more