Efficiency of pooled surveillance testing in academic labs to detect and inhibit COVID-19 outbreaks.
John C Sitko,J. Jordan Steel,Erin A. Almand,Christopher A Cullenbine,Joseph W Rohrer,Douglas P. Wickert,Steven Cm Hasstedt +6 more
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In this article, a strategy of pooling samples, reducing reagent cost and processing time, was employed to mitigate resource limitations, and successful pooled surveillance testing was conducted throughout Fall 2020 semester to detect positive SARS-CoV-2 infections in a population of 4400 students.Abstract:
Robust surveillance testing is a key strategic plan to prevent COVID-19 outbreaks and slow the spread of the SARS-CoV-2 pandemic; however, limited resources, facilities and time often impair the implementation of a widespread surveillance effort. To mitigate these resource limitations, we employed a strategy of pooling samples, reducing reagent cost and processing time. Through utilizing academic faculty and labs, successful pooled surveillance testing was conducted throughout Fall 2020 semester to detect positive SARS-CoV-2 infections in a population of 4400 students. During the semester, over 25,000 individual COVID status evaluations were made by pooling eight individual samples into one quantitative reverse transcription polymerase chain reaction. This pooled surveillance strategy was highly effective at detecting infection and significantly reduced financial burden and cost by $3.6 million.read more
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Phylodynamics of a regional SARS-CoV-2 rapid spreading event in Colorado in late 2020
David M. Pollock,Enke Liu +1 more
TL;DR: In this article , the authors describe the underlying regional phylodynamics before and during a rapid spreading event that was documented by surveillance protocols of the United States Air Force Academy (USAFA) in late October-November of 2020.
References
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TL;DR: The crucial role of diagnostic tests during the first global wave of coronavirus disease 2019 (COVID-19) and the technical and implementation problems encountered during the early phase of the pandemic are explored and future directions for the progressive and better use of diagnostics during a possible resurgence of CO VID-19 in future global waves or regional outbreaks are defined.
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TL;DR: It is hoped that implementation of a pool test for COVID-19 would allow expanding current screening capacities thereby enabling the expansion of detection in the community, as well as in close organic groups, such as hospital departments, army units, or factory shifts.
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TL;DR: When the incidence rate of SARS-CoV-2 infection is 10% or less, group testing will result in the saving of reagents and personnel time with an overall increase in testing capability of at least 69%.